gene

NOX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

105Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

0Experiments

0Debates

Summary

NOX1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, interacts with. Associated with Als, Alzheimer, Atherosclerosis. Connected to 39 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NOX1
Full Name	NADPH Oxidase 1
Chromosome	Xq22
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	certain neuronal populations and glial cells within the brain
Molecular Weight	65 kDa
Amino Acids	564 aa
Pathways	Apoptosis, Complement, Exocytosis, Mitochondrial Function
UniProt ID	[Q9Y5S5](https://www.uniprot.org/uniprot/Q9Y5S5)
Ensembl ID	ENSG00000156508
OMIM	300225
GeneCards	NOX1
Human Protein Atlas	NOX1
6 transmembrane domains	Position heme groups for electron transfer
Dehydrogenase domain	Contains FAD and NADPH binding sites
Associated Diseases	disease, ferroptosis, neurodegeneration, Parkinson, Parkinson's Disease
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AND, ATG5, BECN1, CAT, CDKN1A
KG Connections	105 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NOX1 Gene

gene · 980 words

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Pathway Diagram

graph TD
    NOX1["NOX1"]
    Atherosclerosis{"Atherosclerosis"}
    NOX1 -->|"interacts with"| Atherosclerosis
    Dementia{"Dementia"}
    NOX1 -->|"regulates"| Dementia
    Schizophrenia{"Schizophrenia"}
    NOX1 -->|"regulates"| Schizophrenia
    Alzheimer{"Alzheimer"}
    NOX1 -->|"regulates"| Alzheimer
    Multiple_Sclerosis{"Multiple Sclerosis"}
    NOX1 -->|"regulates"| Multiple_Sclerosis
    Als{"Als"}
    NOX1 -->|"regulates"| Als
    Cancer{"Cancer"}
    NOX1 -->|"regulates"| Cancer
    Ms{"Ms"}
    NOX1 -->|"regulates"| Ms
    ERBB2["ERBB2"]
    NOX1 -->|"interacts with"| ERBB2
    EGFR["EGFR"]
    NOX1 -->|"interacts with"| EGFR
    Angiogenesis(["Angiogenesis"])
    NOX1 -->|"interacts with"| Angiogenesis
    NGF["NGF"]
    NOX1 -->|"regulates"| NGF
    EGF["EGF"]
    EGF -->|"activates"| NOX1
    NBN["NBN"]
    NBN -->|"regulates"| NOX1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| NOX1
    SGK3["SGK3"]
    SGK3 -->|"regulates"| NOX1
    TNF["TNF"]
    TNF -->|"regulates"| NOX1
    CANCER["CANCER"]
    CANCER -->|"regulates"| NOX1
    SLC24A2["SLC24A2"]
    SLC24A2 -->|"regulates"| NOX1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"regulates"| NOX1
    DNAJC2["DNAJC2"]
    DNAJC2 -->|"regulates"| NOX1
    CHMP3["CHMP3"]
    CHMP3 -->|"regulates"| NOX1
    PDE4C["PDE4C"]
    PDE4C -->|"regulates"| NOX1
    BAG1["BAG1"]
    BAG1 -->|"regulates"| NOX1
    style NOX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (64)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NOX1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
FERROPTOSIS	activates	entity	0.88
FERRITINOPHAGY	associated_with	entity	0.85
ROS	activates	gene	0.70
Schizophrenia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Als	regulates	disease	0.65
Dementia	regulates	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Atherosclerosis	interacts_with	disease	0.65
Cancer	regulates	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	activates	disease	0.65
P21	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
senescence	participates_in	pathway	0.60
PARKINSON	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
EGFR	interacts_with	gene	0.60
Dopaminergic	associated_with	cell_type	0.60
Neuron	associated_with	cell_type	0.60
neurodegeneration	associated_with	disease	0.60
PARKINSON'S DISEASE	contributes_to	gene	0.60
Ferroptosis	activates	pathway	0.60
Ferritin	contributes_to	protein	0.60
Angiogenesis	interacts_with	pathway	0.60
COMPLEMENT	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
Exocytosis	regulates	pathway	0.60
Mitochondrial Function	regulates	pathway	0.60
Complement	regulates	pathway	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	associated_with	gene	0.60
AND	activates	gene	0.60
GALNT3	regulates	gene	0.60
IREB2	regulates	gene	0.60
EGF	activates	gene	0.60
ERBB2	interacts_with	gene	0.60
App	associated_with	protein	0.60
TGF	activates	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
NGF	regulates	gene	0.60
DISC1	regulates	gene	0.60
ferroptosis	participates_in	pathway	0.60
neurodegeneration	activates	disease	0.60

Incoming (41)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NOX1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
AND	interacts_with	gene	0.60
ERBB2	interacts_with	gene	0.60
ROS	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
PARKINSON	contributes_to	gene	0.60
APOPTOSIS	regulates	gene	0.60
NBN	regulates	gene	0.60
SGK3	regulates	gene	0.60
TNF	regulates	gene	0.60
SLC24A2	regulates	gene	0.60
DNAJC2	regulates	gene	0.60
CHMP3	regulates	gene	0.60
PDE4C	regulates	gene	0.60
BAG1	regulates	gene	0.60
VTI1B	regulates	gene	0.60
EIF4G1	regulates	gene	0.60
NOX4	activates	gene	0.60
ACTB	activates	gene	0.60
ATG5	activates	gene	0.60
BECN1	activates	gene	0.60
CAT	activates	gene	0.60
CDKN1A	activates	gene	0.60
CTSD	activates	gene	0.60
CYCS	activates	gene	0.60
GAPDH	activates	gene	0.60
GLB1	activates	gene	0.60
LAMP2	activates	gene	0.60
MTOR	activates	gene	0.60
NBR1	activates	gene	0.60
NFE2L2	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CANCER	regulates	gene	0.60
NADPH	activates	gene	0.60
NFKB	activates	gene	0.60
rapamycin	targets	drug	0.60
NEURODEGENERATION	activates	entity	0.60
EGF	activates	gene	0.60
Neurodegeneration	activates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NOX1 in their description or question text

No additional research found