gene

EIF4G1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF4G1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

0Hypotheses

0Analyses

26Outgoing

25Incoming

0Experiments

0Debates

Summary

EIF4G1 encodes eukaryotic translation initiation factor 4 gamma 1, with mutations linked to Parkinson's disease and ALS

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🧬 Gene Info

Gene Symbol	EIF4G1
Chromosome	3p14.2
Function	is a large scaffolding protein (approximately 175 kDa) that serves as the core component of the eIF4F translation initiation complex.
Molecular Weight	220 kDa
Amino Acids	1598 aa
Exons	33
Pathways	NF-κB, mTOR
Ensembl ID	ENSG00000114867
GeneCards	EIF4G1
Human Protein Atlas	EIF4G1
Associated Diseases	neurodegeneration
Interactions	ATG5, ATP13A2, ATXN2, CASP1, CHMP3, DISC1
KG Connections	51 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

EIF4G1 Gene

gene · 1398 words

→

EIF4G1 Protein

protein · 1375 words

→

Pathway Diagram

graph TD
    EIF4G1["EIF4G1"]
    Cancer{"Cancer"}
    EIF4G1 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    EIF4G1 -->|"expressed in"| Tumor
    Parkinson{"Parkinson"}
    EIF4G1 -->|"activates"| Parkinson
    Ms{"Ms"}
    EIF4G1 -->|"therapeutic target"| Ms
    Dementia{"Dementia"}
    EIF4G1 -->|"regulates"| Dementia
    Schizophrenia{"Schizophrenia"}
    EIF4G1 -->|"regulates"| Schizophrenia
    Alzheimer{"Alzheimer"}
    EIF4G1 -->|"regulates"| Alzheimer
    Multiple_Sclerosis{"Multiple Sclerosis"}
    EIF4G1 -->|"regulates"| Multiple_Sclerosis
    Als{"Als"}
    EIF4G1 -->|"regulates"| Als
    EIF4G1 -->|"regulates"| Cancer
    EIF4G1 -->|"regulates"| Ms
    ATG5["ATG5"]
    EIF4G1 -->|"interacts with"| ATG5
    CASP1["CASP1"]
    CASP1 -->|"interacts with"| EIF4G1
    MAPK8["MAPK8"]
    MAPK8 -->|"interacts with"| EIF4G1
    CD8["CD8"]
    CD8 -->|"expressed in"| EIF4G1
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"expressed in"| EIF4G1
    CANCER["CANCER"]
    CANCER -->|"expressed in"| EIF4G1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"expressed in"| EIF4G1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"expressed in"| EIF4G1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| EIF4G1
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"therapeutic target"| EIF4G1
    ATXN2["ATXN2"]
    ATXN2 -->|"activates"| EIF4G1
    LRRK2["LRRK2"]
    LRRK2 -->|"activates"| EIF4G1
    ATP13A2["ATP13A2"]
    ATP13A2 -->|"activates"| EIF4G1
    style EIF4G1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Dementia	regulates	disease	0.65
Schizophrenia	regulates	disease	0.65
Parkinson	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Calcium Signaling	therapeutic_target	pathway	0.60
COMPLEMENT	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
Exocytosis	regulates	pathway	0.60
Mitochondrial Function	regulates	pathway	0.60
ATG5	interacts_with	gene	0.60
Complement	regulates	pathway	0.60
NOX1	regulates	gene	0.60
NGF	regulates	gene	0.60
DISC1	activates	gene	0.60
GALNT3	regulates	gene	0.60
IREB2	activates	gene	0.60
Autophagy	expressed_in	pathway	0.60
Oxidative Stress	expressed_in	pathway	0.60
Mapk	interacts_with	pathway	0.60

Incoming (25)

Source	Relation	Type	Str
CASP1	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
CD8	expressed_in	gene	0.60
ATXN2	activates	gene	0.60
LRRK2	activates	gene	0.60
ATP13A2	activates	gene	0.60
VPS35	activates	gene	0.60
NBN	regulates	gene	0.60
SGK3	regulates	gene	0.60
TNF	regulates	gene	0.60
SLC24A2	regulates	gene	0.60
DNAJC2	regulates	gene	0.60
CHMP3	activates	gene	0.60
PDE4C	regulates	gene	0.60
BAG1	regulates	gene	0.60
VTI1B	regulates	gene	0.60
IMMUNE INFILTRATION	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
ALPHA-SYNUCLEIN	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CANCER	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EIF4G1 in their description or question text

No additional research found