gene

SGK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SGK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

27Outgoing

2Incoming

0Experiments

0Debates

Summary

Comprehensive gene page for SGK3, a serine/threonine kinase involved in PI3K/AKT/mTOR signaling and autophagy regulation relevant to neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	SGK3
Full Name	Serum/Glucocorticoid Regulated Kinase 3
Chromosome	8q12.3
Protein Type	Kinase
Function	The kinase is activated by PDK1-mediated phosphorylation at Thr320, a site conserved across SGK family members [4].
Subcellular Localization	distinguishes SGK3 from other SGK family members and is particularly relevant to [neurodegenerative disease mechanisms](
Amino Acids	644 aa
Exons	14
Pathways	PI3K, mTOR pathway, pi3k, mTOR
Ensembl ID	ENSG00000115297
GeneCards	SGK3
Human Protein Atlas	SGK3
NDRG2	A differentiation-related protein involved in neurite outgrowth
FOXO transcription factors	Regulates neuronal survival and stress responses
Tau protein	SGK3 can phosphorylate tau at multiple sites relevant to Alzheimer's disease pathology [5]
Associated Diseases	neurodegeneration
KG Connections	29 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SGK3 - Serum/Glucocorticoid Regulated Kinase 3

gene · 1435 words

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Pathway Diagram

graph TD
    SGK3["SGK3"]
    Dementia{"Dementia"}
    SGK3 -->|"regulates"| Dementia
    Schizophrenia{"Schizophrenia"}
    SGK3 -->|"regulates"| Schizophrenia
    Alzheimer{"Alzheimer"}
    SGK3 -->|"regulates"| Alzheimer
    Multiple_Sclerosis{"Multiple Sclerosis"}
    SGK3 -->|"regulates"| Multiple_Sclerosis
    Als{"Als"}
    SGK3 -->|"regulates"| Als
    Cancer{"Cancer"}
    SGK3 -->|"regulates"| Cancer
    Ms{"Ms"}
    SGK3 -->|"regulates"| Ms
    TNF["TNF"]
    SGK3 -->|"regulates"| TNF
    CANCER["CANCER"]
    SGK3 -->|"regulates"| CANCER
    SLC24A2["SLC24A2"]
    SGK3 -->|"regulates"| SLC24A2
    APOPTOSIS["APOPTOSIS"]
    SGK3 -->|"regulates"| APOPTOSIS
    DNAJC2["DNAJC2"]
    SGK3 -->|"regulates"| DNAJC2
    NBN["NBN"]
    NBN -->|"regulates"| SGK3
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| SGK3
    style SGK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
Dementia	regulates	disease	0.65
Schizophrenia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Complement	regulates	pathway	0.60
APOPTOSIS	regulates	gene	0.60
COMPLEMENT	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
Exocytosis	regulates	pathway	0.60
Mitochondrial Function	regulates	pathway	0.60
CANCER	regulates	gene	0.60
TNF	regulates	gene	0.60
SLC24A2	regulates	gene	0.60
DNAJC2	regulates	gene	0.60
CHMP3	regulates	gene	0.60
PDE4C	regulates	gene	0.60
BAG1	regulates	gene	0.60
VTI1B	regulates	gene	0.60
EIF4G1	regulates	gene	0.60
NOX1	regulates	gene	0.60
NGF	regulates	gene	0.60
DISC1	regulates	gene	0.60
GALNT3	regulates	gene	0.60
IREB2	regulates	gene	0.60

Incoming (2)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	regulates	gene	0.60
NBN	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SGK3 in their description or question text

No additional research found