concept

EXOCYTOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXOCYTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

327Connections

3Hypotheses

0Analyses

16Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	EXOCYTOSIS

Pathway Diagram

graph TD
    EXOCYTOSIS["EXOCYTOSIS"]
    EXOCYTOSIS -->|"interacts"| Endocytosis["Endocytosis"]
    EXOCYTOSIS -->|"interacts"| Complement["Complement"]
    EXOCYTOSIS -->|"interacts"| Autophagy["Autophagy"]
    EXOCYTOSIS -->|"interacts"| Angiogenesis["Angiogenesis"]
    EXOCYTOSIS -->|"interacts"| Apoptosis["Apoptosis"]
    EXOCYTOSIS -->|"interacts"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    EXOCYTOSIS -->|"interacts"| Mtor["Mtor"]
    EXOCYTOSIS -->|"interacts"| Mitophagy["Mitophagy"]
    TARDBP["TARDBP"] -->|"expressed in"| EXOCYTOSIS
    NTN1["NTN1"] -->|"expressed in"| EXOCYTOSIS
    SNRNP70["SNRNP70"] -->|"expressed in"| EXOCYTOSIS
    JUN["JUN"] -->|"expressed in"| EXOCYTOSIS
    NTN3["NTN3"] -->|"expressed in"| EXOCYTOSIS
    C9ORF72["C9ORF72"] -->|"target for"| EXOCYTOSIS
    FUS["FUS"] -->|"target for"| EXOCYTOSIS
    ANXA1["ANXA1"] -->|"target for"| EXOCYTOSIS

Outgoing (16)

Target	Relation	Type	Str
Endocytosis	interacts_with	pathway	0.55
Complement	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Mitophagy	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Angiogenesis	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Proteins	regulates	protein	0.50
PIKFYVE	activates	concept	0.50
Proteins	activates	protein	0.50
CX43	associated_with	concept	0.50
GLUTAMATE	activates	concept	0.50
Glutamate Signaling	activates	pathway	0.50
Proteins	associated_with	protein	0.50
Proteins	interacts_with	protein	0.50

Incoming (311)

Source	Relation	Type	Str
GJA1	promotes	protein	0.95
GJA1	associated_with	protein	0.90
Annexins	involved_in	protein	0.85
ANNEXINS	involved_in	protein	0.80
Cancer	therapeutic_target	disease	0.80
EXOSOMES	activates	gene	0.80
Inflammation	therapeutic_target	disease	0.70
Tumor	therapeutic_target	disease	0.70
CANCER	therapeutic_target	gene	0.70
FERROPTOSIS	therapeutic_target	gene	0.70
Inflammation	activates	disease	0.70
UBIQUITIN	activates	gene	0.70
Als	therapeutic_target	disease	0.70
COMPLEMENT	regulates	gene	0.70
Alzheimer	associated_with	disease	0.65
SNRNP70	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
NTN3	expressed_in	gene	0.60
SOD1	activates	gene	0.60
PLEKHG5	activates	gene	0.60
Ms	associated_with	disease	0.60
ANXA2	inhibits	gene	0.60
Cancer	regulates	disease	0.60
Ms	regulates	disease	0.60
Neuropathy	associated_with	disease	0.60
OTOF	activates	gene	0.60
Ms	activates	disease	0.60
Ms	contributes_to	disease	0.60
JUN	associated_with	gene	0.60
NTN1	associated_with	gene	0.60
NTN3	associated_with	gene	0.60
SNRNP70	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
MMP9	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
CYTOKINES	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ANXA2	expressed_in	gene	0.60
Als	activates	disease	0.60
TARDBP	expressed_in	gene	0.60
NTN1	expressed_in	gene	0.60
JUN	contributes_to	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
DEPRESSION	contributes_to	gene	0.60
ANXA1	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
NEUROINFLAMMATION	contributes_to	gene	0.60
ANXA2	contributes_to	gene	0.60
EPILEPSY	expressed_in	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Targeting Synaptic Vesicle Release Machinery to Block Tau Ex	0.630	neuroscience	Trans-synaptic tau spreading and propaga
PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5	0.584	neurodegeneration	How does PIKFYVE inhibition activate unc
C9orf72-SMCR8-WDR41 Complex Dysfunction in C9-ALS Rescued by	0.562	neurodegeneration	How does PIKFYVE inhibition activate unc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
PPP3/calcineurin-dependent TFEB dephosphorylation mechanism	exploratory	motoneuron degeneration	0.800	0.00	neuronal cell lines	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity