Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | DNAJC2 |
| Full Name | DnaJ Heat Shock Protein Family Member C2 |
| Aliases | Page for DNAJC2, Page for DNAJC2 Protein |
| Chromosome | 9p24. |
| Protein Type | Chaperone |
| Function | In neurons, DNAJC2 participates in |
| Primary Expression | various brain regions: |
| Molecular Weight | 66.3 kDa |
| Amino Acids | 640 aa |
| Pathways | Apoptosis, Complement, Exocytosis, Mitochondrial Function |
| UniProt ID | [Q9Y2H5](https://www.uniprot.org/uniprot/Q9Y2H5) |
| Ensembl ID | ENSG00000137770 |
| GeneCards | DNAJC2 |
| Human Protein Atlas | DNAJC2 |
| Neuroprotection | Protects neurons against proteotoxic stress |
| Associated Diseases | neurodegeneration |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJC2["DNAJC2"]
Dementia{"Dementia"}
DNAJC2 -->|"regulates"| Dementia
Schizophrenia{"Schizophrenia"}
DNAJC2 -->|"regulates"| Schizophrenia
Alzheimer{"Alzheimer"}
DNAJC2 -->|"regulates"| Alzheimer
Multiple_Sclerosis{"Multiple Sclerosis"}
DNAJC2 -->|"regulates"| Multiple_Sclerosis
Als{"Als"}
DNAJC2 -->|"regulates"| Als
Cancer{"Cancer"}
DNAJC2 -->|"regulates"| Cancer
Ms{"Ms"}
DNAJC2 -->|"regulates"| Ms
CHMP3["CHMP3"]
DNAJC2 -->|"regulates"| CHMP3
PDE4C["PDE4C"]
DNAJC2 -->|"regulates"| PDE4C
BAG1["BAG1"]
DNAJC2 -->|"associated with"| BAG1
VTI1B["VTI1B"]
DNAJC2 -->|"regulates"| VTI1B
EIF4G1["EIF4G1"]
DNAJC2 -->|"regulates"| EIF4G1
NBN["NBN"]
NBN -->|"regulates"| DNAJC2
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"regulates"| DNAJC2
SGK3["SGK3"]
SGK3 -->|"regulates"| DNAJC2
TNF["TNF"]
TNF -->|"associated with"| DNAJC2
CANCER["CANCER"]
CANCER -->|"regulates"| DNAJC2
SLC24A2["SLC24A2"]
SLC24A2 -->|"regulates"| DNAJC2
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"regulates"| DNAJC2
style DNAJC2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | regulates | disease | 0.65 |
| Dementia | regulates | disease | 0.65 |
| Schizophrenia | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Multiple Sclerosis | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Complement | regulates | pathway | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
| Exocytosis | regulates | pathway | 0.60 |
| Mitochondrial Function | regulates | pathway | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| CHMP3 | regulates | gene | 0.60 |
| PDE4C | regulates | gene | 0.60 |
| BAG1 | associated_with | gene | 0.60 |
| VTI1B | regulates | gene | 0.60 |
| EIF4G1 | regulates | gene | 0.60 |
| NOX1 | regulates | gene | 0.60 |
| NGF | regulates | gene | 0.60 |
| DISC1 | associated_with | gene | 0.60 |
| GALNT3 | associated_with | gene | 0.60 |
| IREB2 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DNAJC2 in their description or question text
No additional research found