gene

CHMP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHMP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

24Outgoing

9Incoming

0Experiments

0Debates

Summary

ESCRT-III core component involved in membrane remodeling, autophagy, and lysosomal degradation - implicated in neurodegeneration

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🧬 Gene Info

Gene Symbol	CHMP3
Full Name	Charged Multivesicular Body Protein 3
Chromosome	2p21
Function	is a core component of the Endosomal Sorting Complex Required for Transport-III (ESCRT-III)[@hanson2012].
Primary Expression	neurons and has been increasingly recognized for its critical role in maintaining neuronal protein homeostasis[@lee2019]
Molecular Weight	24 kDa
Amino Acids	222 aa
Pathways	Apoptosis, Complement, Exocytosis, Mitochondrial Function
UniProt ID	Q9Y3E0
NCBI Gene ID	25973
Ensembl ID	ENSG00000115159
OMIM	609538
GeneCards	CHMP3
Human Protein Atlas	CHMP3
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	CHMP2A, CHMP4B, CHMP6, DISC1, EIF4G1, ESCRT-III
KG Connections	33 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CHMP3 — AlphaFold Q9Y3E0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CHMP3 — Charged Multivesicular Body Protein 3

gene · 2253 words

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Pathway Diagram

graph TD
    CHMP3["CHMP3"]
    Dementia{"Dementia"}
    CHMP3 -->|"regulates"| Dementia
    Schizophrenia{"Schizophrenia"}
    CHMP3 -->|"regulates"| Schizophrenia
    Alzheimer{"Alzheimer"}
    CHMP3 -->|"regulates"| Alzheimer
    Multiple_Sclerosis{"Multiple Sclerosis"}
    CHMP3 -->|"regulates"| Multiple_Sclerosis
    Als{"Als"}
    CHMP3 -->|"regulates"| Als
    Cancer{"Cancer"}
    CHMP3 -->|"regulates"| Cancer
    Ms{"Ms"}
    CHMP3 -->|"regulates"| Ms
    PDE4C["PDE4C"]
    CHMP3 -->|"regulates"| PDE4C
    BAG1["BAG1"]
    CHMP3 -->|"regulates"| BAG1
    VTI1B["VTI1B"]
    CHMP3 -->|"regulates"| VTI1B
    EIF4G1["EIF4G1"]
    CHMP3 -->|"activates"| EIF4G1
    NOX1["NOX1"]
    CHMP3 -->|"regulates"| NOX1
    NBN["NBN"]
    NBN -->|"regulates"| CHMP3
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| CHMP3
    SGK3["SGK3"]
    SGK3 -->|"regulates"| CHMP3
    TNF["TNF"]
    TNF -->|"regulates"| CHMP3
    CANCER["CANCER"]
    CANCER -->|"regulates"| CHMP3
    SLC24A2["SLC24A2"]
    SLC24A2 -->|"regulates"| CHMP3
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"regulates"| CHMP3
    DNAJC2["DNAJC2"]
    DNAJC2 -->|"regulates"| CHMP3
    style CHMP3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

Target	Relation	Type	Str
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
Dementia	regulates	disease	0.65
Schizophrenia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Als	regulates	disease	0.65
DISC1	activates	gene	0.60
GALNT3	regulates	gene	0.60
IREB2	activates	gene	0.60
COMPLEMENT	regulates	gene	0.60
Complement	regulates	pathway	0.60
PDE4C	regulates	gene	0.60
BAG1	regulates	gene	0.60
VTI1B	regulates	gene	0.60
EIF4G1	activates	gene	0.60
NOX1	regulates	gene	0.60
NGF	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
Exocytosis	regulates	pathway	0.60
Mitochondrial Function	regulates	pathway	0.60
CHMP6	interacts_with	gene	0.55
CHMP4B	interacts_with	gene	0.55
ESCRT-III	interacts_with	gene	0.55

Incoming (9)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	regulates	gene	0.60
CANCER	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
NBN	regulates	gene	0.60
SGK3	regulates	gene	0.60
TNF	regulates	gene	0.60
SLC24A2	regulates	gene	0.60
DNAJC2	regulates	gene	0.60
CHMP2A	interacts_with	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHMP3 in their description or question text

No additional research found