gene

PDE4C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDE4C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

20Outgoing

9Incoming

0Experiments

0Debates

Summary

PDE4C is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Als, Alzheimer, Cancer. Connected to 30 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PDE4C
Full Name	Phosphodiesterase 4C
Chromosome	19q13.12
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	68 kDa
Pathways	Apoptosis, Complement, Exocytosis, Mitochondrial Function
UniProt ID	[Q08431](https://www.uniprot.org/uniprot/Q08431)
Ensembl ID	ENSG00000074527
OMIM	610172
GeneCards	PDE4C
Human Protein Atlas	PDE4C
Lung	Highest expression in airway smooth muscle and epithelial cells
Brain	Moderate expression in cortex, hippocampus, and cerebellum
Testis	High expression in spermatogenic cells
Immune cells	Present in mast cells and eosinophils
Associated Diseases	neurodegeneration
Interactions	NGF, SLC24A2
KG Connections	29 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PDE4C — Phosphodiesterase 4C

gene · 1222 words

→

PDE4C Protein — Phosphodiesterase 4C

protein · 583 words

→

Pathway Diagram

graph TD
    PDE4C["PDE4C"]
    Dementia{"Dementia"}
    PDE4C -->|"regulates"| Dementia
    Schizophrenia{"Schizophrenia"}
    PDE4C -->|"regulates"| Schizophrenia
    Alzheimer{"Alzheimer"}
    PDE4C -->|"regulates"| Alzheimer
    Multiple_Sclerosis{"Multiple Sclerosis"}
    PDE4C -->|"regulates"| Multiple_Sclerosis
    Als{"Als"}
    PDE4C -->|"regulates"| Als
    Cancer{"Cancer"}
    PDE4C -->|"regulates"| Cancer
    Ms{"Ms"}
    PDE4C -->|"regulates"| Ms
    BAG1["BAG1"]
    PDE4C -->|"regulates"| BAG1
    VTI1B["VTI1B"]
    PDE4C -->|"regulates"| VTI1B
    EIF4G1["EIF4G1"]
    PDE4C -->|"regulates"| EIF4G1
    NOX1["NOX1"]
    PDE4C -->|"regulates"| NOX1
    NGF["NGF"]
    PDE4C -->|"activates"| NGF
    NBN["NBN"]
    NBN -->|"regulates"| PDE4C
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| PDE4C
    SGK3["SGK3"]
    SGK3 -->|"regulates"| PDE4C
    TNF["TNF"]
    TNF -->|"regulates"| PDE4C
    CANCER["CANCER"]
    CANCER -->|"regulates"| PDE4C
    SLC24A2["SLC24A2"]
    SLC24A2 -->|"activates"| PDE4C
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"regulates"| PDE4C
    DNAJC2["DNAJC2"]
    DNAJC2 -->|"regulates"| PDE4C
    CHMP3["CHMP3"]
    CHMP3 -->|"regulates"| PDE4C
    style PDE4C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
Dementia	regulates	disease	0.65
Schizophrenia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
IREB2	regulates	gene	0.60
COMPLEMENT	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
Exocytosis	regulates	pathway	0.60
Mitochondrial Function	regulates	pathway	0.60
BAG1	regulates	gene	0.60
Complement	regulates	pathway	0.60
VTI1B	regulates	gene	0.60
EIF4G1	regulates	gene	0.60
NOX1	regulates	gene	0.60
NGF	activates	gene	0.60
DISC1	regulates	gene	0.60
GALNT3	regulates	gene	0.60

Incoming (9)

Source	Relation	Type	Str
NBN	regulates	gene	0.60
SGK3	regulates	gene	0.60
TNF	regulates	gene	0.60
SLC24A2	activates	gene	0.60
DNAJC2	regulates	gene	0.60
CHMP3	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CANCER	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PDE4C in their description or question text

No additional research found