gene

vti1b

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about vti1b: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

0Analyses

19Outgoing

16Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	VTI1B
Protein Type	Receptor
Function	VTI1B is a vesicle-SNARE (v-SNARE) protein essential for intracellular membrane fusion events:
Molecular Weight	23 kDa
Pathways	Apoptosis, Exocytosis, Mitochondrial Function, Complement
Ensembl ID	ENSG00000106052
GeneCards	VTI1B
Human Protein Atlas	VTI1B
Q-SNARE Properties	VTI1B is a Qa-SNARE (glutamine-containing SNARE) that contributes one or more "layers" to the SNARE pin
Complex Formation	VTI1B typically interacts with syntaxins and SNAP-25 family members
Zippering	Assembly of the SNARE complex proceeds from N- to C-terminus, driving membrane fusion
Trans-Golgi Network to Endosomes	VTI1B is involved in trafficking from the TGN to early endosomes
Endosomal Maturation	VTI1B participates in the conversion from early to late endosomes
Late Endosome-Lysosome Fusion	Critical for lysosomal function and degradation pathways
Autophagosome-Lysosome Fusion	Essential for autophagy completion
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

vti1b

gene · 1294 words

→

Pathway Diagram

graph TD
    VTI1B["VTI1B"]
    VTI1B -->|"regulates"| Dementia["Dementia"]
    VTI1B -->|"regulates"| Schizophrenia["Schizophrenia"]
    VTI1B -->|"regulates"| Alzheimer["Alzheimer"]
    VTI1B -->|"regulates"| Multiple_Sclerosis["Multiple Sclerosis"]
    VTI1B -->|"regulates"| Als["Als"]
    VTI1B -->|"regulates"| Cancer["Cancer"]
    VTI1B -->|"regulates"| Ms["Ms"]
    VTI1B -->|"regulates"| EIF4G1["EIF4G1"]
    NBN["NBN"] -->|"regulates"| VTI1B
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| VTI1B
    SGK3["SGK3"] -->|"regulates"| VTI1B
    TNF["TNF"] -->|"regulates"| VTI1B
    CANCER["CANCER"] -->|"regulates"| VTI1B
    SLC24A2["SLC24A2"] -->|"regulates"| VTI1B
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| VTI1B
    DNAJC2["DNAJC2"] -->|"regulates"| VTI1B

Outgoing (19)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:VTI1B	data_in	dataset_row	0.00
Ms	regulates	disease	0.65
Dementia	regulates	disease	0.65
Schizophrenia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Complement	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Exocytosis	regulates	pathway	0.60
Mitochondrial Function	regulates	pathway	0.60
COMPLEMENT	regulates	gene	0.60
EIF4G1	regulates	gene	0.60
NOX1	regulates	gene	0.60
NGF	regulates	gene	0.60
DISC1	regulates	gene	0.60
GALNT3	regulates	gene	0.60
IREB2	regulates	gene	0.60

Incoming (16)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:VTI1B	data_in	dataset_row	0.00
SNARE	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CANCER	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
NBN	regulates	gene	0.60
SGK3	regulates	gene	0.60
TNF	regulates	gene	0.60
SLC24A2	regulates	gene	0.60
DNAJC2	regulates	gene	0.60
CHMP3	regulates	gene	0.60
PDE4C	regulates	gene	0.60
BAG1	regulates	gene	0.60
PARK7	regulates	gene	0.60
SEC22B	regulates	gene	0.60
STX3	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning vti1b in their description or question text

No additional research found