gene

MAP1LC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP1LC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1353Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MAP1LC3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with AD, ALI, ALS. Connected to 612 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAP1LC3
Pathways	Autophagy
GeneCards	MAP1LC3
Human Protein Atlas	MAP1LC3
Associated Diseases	AD, ALI, Als, Alzheimer, AMI
Known Drugs/Compounds	dimethyl fumarate, rapamycin, statins
Interactions	4E-BP1, ABCA1, ABCG1, ABP, ACAT1, ACOX1
KG Connections	1350 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (9)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MAP1LC3["MAP1LC3"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    MAP1LC3["MAP1LC3"] -->|"interacts"| Als["Als"]
    MAP1LC3["MAP1LC3"] -->|"interacts"| Dementia["Dementia"]
    MAP1LC3["MAP1LC3"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MAP1LC3["MAP1LC3"] -->|"associated"| Glioblastoma["Glioblastoma"]
    MAP1LC3["MAP1LC3"] -->|"associated"| Tumor["Tumor"]
    LYC["LYC"] -->|"increases risk"| MAP1LC3["MAP1LC3"]
    ATG5["ATG5"] -->|"interacts"| MAP1LC3["MAP1LC3"]
    SQSTM1["SQSTM1"] -->|"interacts"| MAP1LC3["MAP1LC3"]
    SQSTM1_1["SQSTM1"] -->|"associated"| MAP1LC3["MAP1LC3"]
    style MAP1LC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (742)

Target	Relation	Type	Str
MAP1LC3	encodes	protein	0.00
LC3	activates	gene	1.00
LC3	associated_with	gene	1.00
Autophagy	activates	pathway	1.00
autophagosome formation	involved_in	process	0.95
neural stem cells	activates	cell_type	0.90
autophagy	regulates	process	0.90
neural stem cells	regulates	cell_type	0.90
SQSTM1	associated_with	protein	0.90
SQSTM1	regulates	gene	0.90
ULK1	regulates	gene	0.90
oxidative stress response	participates_in	pathway	0.90
ULK1	activates	gene	0.90
Autophagy	associated_with	process	0.90
autophagy	biomarker_for	process	0.90
Autophagy	biomarker_for	process	0.85
Cancer	associated_with	disease	0.85
frontotemporal dementia	activates	disease	0.80
RNA	activates	gene	0.80
stem cells	expressed_in	cell_type	0.80
autophagy pathway	participates_in	pathway	0.80
STX17	activates	gene	0.80
STX17	regulates	gene	0.80
RNA	regulates	gene	0.80
neural stem cells	interacts_with	cell_type	0.80
MTOR	regulates	gene	0.80
MTORC1	regulates	gene	0.80
AUTOPHAGY	biomarker_for	process	0.80
Mitophagy	activates	pathway	0.80
Autophagy	interacts_with	pathway	0.80
P62	activates	gene	0.80
CANCER	associated_with	gene	0.80
Mtor	associated_with	pathway	0.80
Als	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
Tumor	associated_with	disease	0.75
SIRT1	regulates	gene	0.70
RAS	regulates	gene	0.70
TP53	regulates	gene	0.70
RAS	activates	gene	0.70
PINK1	interacts_with	gene	0.70
neurons	activates	cell_type	0.70
unfolded protein response	participates_in	pathway	0.70
ATG	associated_with	gene	0.70
Mtor	activates	pathway	0.70
MTOR	activates	gene	0.70
GENES	activates	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
Apoptosis	associated_with	pathway	0.70
UBIQUITIN	activates	gene	0.70

Incoming (611)

Source	Relation	Type	Str
MAP1LC3	encodes	gene	0.00
Acetylation	modulates	mechanism	0.95
ATG4B	substrate_of	protein	0.92
TGM2	associated_with	gene	0.90
ATG12-ATG5-ATG16L1 COMPLEX	catalyzes	protein	0.90
BECN1	regulates	gene	0.90
rapamycin	targets	drug	0.90
LC3	regulates	gene	0.90
Mc3R Agonists	upregulates	drug	0.90
MITOPHAGY	activates	gene	0.90
AUTOPHAGY	activates	gene	0.90
PARKIN	associated_with	protein	0.87
PI3K-AKT	regulates	pathway	0.85
MC3R	upregulates	protein	0.85
LYC	contributes_to	drug	0.80
GAPDH	regulates	gene	0.80
ATG	regulates	gene	0.80
AMPK	regulates	gene	0.80
CALCOCO2	regulates	gene	0.80
BECN1	activates	gene	0.80
RIPK2	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
SRSF1	binds	protein	0.70
DMSO	associated_with	gene	0.70
ATG	interacts_with	gene	0.70
PI3K	associated_with	gene	0.70
LAMP1	regulates	gene	0.70
CREB	regulates	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
ULK1	associated_with	gene	0.70
APOPTOSIS	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
ATG5	interacts_with	gene	0.70
GFP	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
ACTB	regulates	gene	0.70
GFP	associated_with	gene	0.70
MTOR	associated_with	gene	0.60
LDL	interacts_with	gene	0.60
ATG14	associated_with	gene	0.60
AMPK	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
EPG5	associated_with	gene	0.60
SQSTM1	activates	gene	0.60
NEURON	associated_with	gene	0.60
APOE	inhibits	gene	0.60
ACTB	associated_with	gene	0.60
P62	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAP1LC3 in their description or question text

No additional research found

MAP1LC3

Understanding Entity Pages

Summary

Wiki Pages (9)

MAP1LC3A Gene

MAP1LC3B — LC3B

LC3 (MAP1LC3) Neurons

MAP1LC3A Gene

MAP1LC3B2 Protein

MAP1LC3B2 Gene

MAP1LC3A Protein

MAP1LC3C Gene

MAP1LC3B Protein (LC3B)