Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MC3R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | MC3R |
| Key Genes/Proteins | ATXN3, CHD4, EIF4EBP1, GFP, LC3 |
| Related Diseases | body weight, energy expenditure |
| Related Pathways | autophagy pathway |
graph TD
MC3R[MC3R]
MC3R -->|activates| autophagy[autophagy]
MC3R -->|expressed in| hepatocyte[hepatocyte]
MC3R -->|regulates| Lipid_Droplet_Autophagy[Lipid Droplet Autophagy]
MC3R -->|regulates| Liver_Steatosis[Liver Steatosis]
MC3R -->|regulates| Autophagy[Autophagy]
MC3R -->|regulates| lipid_droplet_clearance[lipid droplet clearance]
MC3R -->|suppresses| liver_steatosis[liver steatosis]
MC3R -->|suppresses| triglyceride_accumulation[triglyceride accumulation]
MC3R -->|upregulates| Map1Lc3[Map1Lc3]
MC3R -->|modulates| TFEB[TFEB]
LC3[LC3] -->|activates| MC3R
EIF4EBP1[EIF4EBP1] -->|regulates| MC3R
ATXN3[ATXN3] -->|regulates| MC3R
CHD4[CHD4] -->|regulates| MC3R
GFP[GFP] -->|regulates| MC3R
MAP1LC3[MAP1LC3] -->|regulates| MC3R
rapamycin[rapamycin] -->|targets| MC3R| Target | Relation | Type | Str |
|---|---|---|---|
| hepatocyte | expressed_in | cell_type | 0.95 |
| Liver Steatosis | regulates | disease | 0.95 |
| autophagy | activates | process | 0.95 |
| Lipid Droplet Autophagy | regulates | process | 0.95 |
| Autophagy | regulates | process | 0.95 |
| lipid droplet clearance | regulates | process | 0.90 |
| liver steatosis | suppresses | disease | 0.90 |
| triglyceride accumulation | suppresses | phenotype | 0.90 |
| Lipid Metabolism | regulates | process | 0.85 |
| Map1Lc3 | upregulates | protein | 0.85 |
| TFEB | modulates | protein | 0.85 |
| autophagosome-lysosome docking | promotes | process | 0.85 |
| Metabolic-associated fatty liver disease | therapeutic_target | disease | 0.85 |
| body weight | suppresses | phenotype | 0.80 |
| lipolysis | regulates | process | 0.80 |
| energy expenditure | promotes | phenotype | 0.80 |
| mitochondrial respiration | upregulates | process | 0.80 |
| oxidative stress response | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| TFEB | regulates | gene | 0.60 |
| TFEB | activates | gene | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MC3R in their description or question text
No additional research found