concept

AUTOPHAGOSOME FORMATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AUTOPHAGOSOME FORMATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

0Hypotheses

1Analyses

3Outgoing

31Incoming

0Experiments

1Debates

No summary available yet.

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💡 Concept Info

Name	AUTOPHAGOSOME FORMATION

Pathway Diagram

graph TD
    AUTOPHAGOSOME_FORMATION["AUTOPHAGOSOME FORMATION"]
    AUTOPHAGOSOME_FORMATION -->|"involved_in"| ER_Mitochondria_Contact_Site["ER-Mitochondria Contact Site"]
    AUTOPHAGOSOME_FORMATION -->|"component_of"| Autophagy["Autophagy"]
    Autophagy -->|"involved_in"| AUTOPHAGOSOME_FORMATION
    ER_Mitochondria_Contact_Sites["ER-Mitochondria Contact Sites"] -->|"involved_in"| AUTOPHAGOSOME_FORMATION
    BECN1_PIK3C3_Complex["BECN1-PIK3C3 Complex"] -->|"involved_in"| AUTOPHAGOSOME_FORMATION
    Isolation_Membranes["Isolation Membranes"] -->|"involved_in"| AUTOPHAGOSOME_FORMATION
    LC3["LC3"] -->|"mediates"| AUTOPHAGOSOME_FORMATION
    MAP1LC3_Lipidation["MAP1LC3 Lipidation"] -->|"contributes to"| AUTOPHAGOSOME_FORMATION
    BECN1["BECN1"] -->|"involved_in"| AUTOPHAGOSOME_FORMATION

Outgoing (3)

Target	Relation	Type	Str
ER-Mitochondria Contact Site	involved_in	mechanism	0.95
Autophagy	component_of	process	0.90
ATG	associated_with	protein	0.90

Incoming (31)

Source	Relation	Type	Str
ER-mitochondria contact site	mediates	process	0.96
Autophagy	involved_in	process	0.95
ER-Mitochondria Contact Sites	involved_in	organelle	0.95
Map1Lc3	involved_in	protein	0.95
ATG14	involved_in	protein	0.93
ATG5	involved_in	protein	0.92
ATG2A-G433A	inhibits	variant	0.92
mitochondria-associated ER membrane	mediates	process	0.91
RAB7A	promotes	protein	0.90
Isolation Membranes	involved_in	mechanism	0.90
MAP1LC3 Lipidation	contributes_to	process	0.90
BECN1	involved_in	gene	0.90
LC3B	biomarker_for	protein	0.90
ER-mitochondria contact sites	mediates	organelle	0.90
LC3	mediates	entity	0.90
BECN1-PIK3C3 Complex	involved_in	protein	0.90
SQSTM1	associated_with	protein	0.90
BECN1	activates	gene	0.90
LC3	regulates	protein	0.90
STX17	involved_in	protein	0.85
ATG14	biomarker_for	protein	0.85
ATG9A	involved_in	protein	0.85
ER-mitochondria contact sites	promotes	organelle	0.80
ACETYLATION	regulates	process	0.80
LRRK2	regulates	protein	0.80
BECN1	regulates	gene	0.70
MAP1LC3B	part_of	gene	0.70
ATG41	activates	protein	0.70
PI3P generation	activates	process	0.70
ULK1	activates	protein	0.70
ATG9	activates	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does controlled lysosomal membrane permeabilization induce autophagy without

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.690

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study shows trehalose causes lysosomal membrane permeabilization (LMP) that

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

Related Research

Hypotheses and analyses mentioning AUTOPHAGOSOME FORMATION in their description or question text

No additional research found