gene

TCF7L2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TCF7L2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections

0Hypotheses

0Analyses

50Outgoing

14Incoming

0Experiments

0Debates

Summary

TCF7L2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, inhibits. Associated with Aging, Als, Atherosclerosis. Connected to 43 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TCF7L2
Aliases	Transcription Factor 7-Like 2
Protein Type	Transcription Factor
Function	TCF7L2 serves multiple physiological functions
Pathways	Wnt, wnt, Wnt signaling, Wnt Signaling
UniProt ID	Q9NQB0](https://www.uniprot.org/uniprot/Q9NQB0)
NCBI Gene ID	6934
GeneCards	TCF7L2
Human Protein Atlas	TCF7L2
β-catenin binding domain	N-terminal region for interaction with β-catenin
HMG box	DNA-binding domain recognizing Wnt-responsive elements (WRE)
C-clamp	Additional DNA-binding domain enhancing specificity
Repression domains	Bind Groucho/TLE co-repressors in absence of Wnt signaling[@cadigan2012]
Associated Diseases	Als, Diabetes, Type 2 Diabetes, Type 2 Diabetes Mellitus
Interactions	APOA2, CANCER, FOXO3, GENES, IL1R1, IL-6
KG Connections	67 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TCF7L2 (Transcription Factor 7-Like 2)

gene · 955 words

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Pathway Diagram

graph TD
    TCF7L2["TCF7L2"]
    Cancer{"Cancer"}
    TCF7L2 -->|"activates"| Cancer
    Als{"Als"}
    TCF7L2 -->|"inhibits"| Als
    GENES["GENES"]
    TCF7L2 -->|"inhibits"| GENES
    LGALS3["LGALS3"]
    TCF7L2 -->|"inhibits"| LGALS3
    MYC["MYC"]
    TCF7L2 -->|"activates"| MYC
    P53["P53"]
    TCF7L2 -->|"inhibits"| P53
    Nf__b(["Nf-Kappab"])
    TCF7L2 -->|"inhibits"| Nf__b
    NF__B["NF-KappaB"]
    TCF7L2 -->|"inhibits"| NF__B
    CANCER["CANCER"]
    TCF7L2 -->|"activates"| CANCER
    neurodegeneration["neurodegeneration"]
    TCF7L2 -->|"implicated in"| neurodegeneration
    FOXO3["FOXO3"]
    FOXO3 -->|"activates"| TCF7L2
    LGALS3 -->|"inhibits"| TCF7L2
    P53 -->|"inhibits"| TCF7L2
    MYC -->|"activates"| TCF7L2
    style TCF7L2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (53)

Target	Relation	Type	Str
GLP-1 Receptor	regulates	receptor	0.80
GIP Receptor	regulates	receptor	0.80
insulin secretion	regulates	biological_process	0.80
Type 2 Diabetes Mellitus	associated_with	disease	0.80
Longevity	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Coronary Artery Disease	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Diabetes	associated_with	disease	0.65
Als	associated_with	disease	0.65
Type 2 Diabetes	associated_with	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	activates	disease	0.65
Als	inhibits	disease	0.65
Cardiovascular	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
NF-ΚB	inhibits	gene	0.60
CANCER	activates	gene	0.60
IL-6	interacts_with	gene	0.60
INFLAMMATION	regulates	gene	0.60
GENES	regulates	gene	0.60
Oxidative Stress	regulates	pathway	0.60
Wnt signaling	participates_in	pathway	0.60
T cells	expressed_in	cell_type	0.60
LGALS3	inhibits	gene	0.60
IL1R1	interacts_with	gene	0.60
MYC	activates	gene	0.60
Nfkb	associated_with	protein	0.60
MITF	transports	gene	0.60
schizophrenia	inhibits	disease	0.60
glutamate signaling	participates_in	pathway	0.60
GENES	inhibits	gene	0.60
P53	inhibits	gene	0.60
Nf-Κb	inhibits	pathway	0.60
TFAP4	associated_with	gene	0.60
AGING	therapeutic_target	gene	0.60
HIF1A	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
APOA2	interacts_with	gene	0.60
SLC30A8	associated_with	gene	0.60
MTNR1B	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Huntington's disease	inhibits	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
FOSL2	associated_with	gene	0.60

Incoming (14)

Source	Relation	Type	Str
h-eef1be45	targets	hypothesis	0.90
FOXO3	activates	gene	0.60
LGALS3	inhibits	gene	0.60
MYC	activates	gene	0.60
OLIG2	inhibits	gene	0.60
OLIG2	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
FGFR3	associated_with	gene	0.60
NOX4	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
P53	inhibits	gene	0.60
ARNT2	transports	gene	0.60
NCOR1	transports	gene	0.60
TCF4	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TCF7L2 in their description or question text

No additional research found