gene

TAB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

0Hypotheses

0Analyses

23Outgoing

9Incoming

0Experiments

0Debates

Summary

Comprehensive coverage of TAB1 in TAK1 complex formation, NF-κB signaling, MAPK pathways, neuroinflammation, and implications for Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TAB1
Full Name	TAK1-Binding Protein 1
Chromosome	11q13.1
Protein Type	Adaptor Protein
Function	is an adaptor protein that forms a critical complex with TAK1 (Transforming Growth Factor Beta-Activated Kinase 1).
Subcellular Localization	both cytoplasm and nucleus
Molecular Weight	110 kDa
Amino Acids	504 aa
Pathways	NF-κB, MAPK, TGF-β, MAPK pathway, MAPK signaling
UniProt ID	Q61240
NCBI Gene ID	10454
Ensembl ID	ENSG00000100994
OMIM	602475
GeneCards	TAB1
Human Protein Atlas	TAB1
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	CANCER, CYTOKINES, IL1B, IL-6, INFLAMMATION, MAPK
KG Connections	32 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TAB1 — AlphaFold Q61240 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TAB1["TAB1"]
    IL1B["IL1B"]
    TAB1 -->|"activates"| IL1B
    MAPK14["MAPK14"]
    TAB1 -->|"activates"| MAPK14
    TRAF6["TRAF6"]
    TAB1 -->|"binds"| TRAF6
    MAPK3["MAPK3"]
    TAB1 -->|"activates"| MAPK3
    MAPK1["MAPK1"]
    TAB1 -->|"activates"| MAPK1
    neurodegeneration["neurodegeneration"]
    TAB1 -->|"implicated in"| neurodegeneration
    style TAB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (23)

Target	Relation	Type	Str
NF-κB signaling	upstream_of	pathway	0.92
IL1B	activates	protein	0.80
MAPK14	activates	protein	0.70
TRAF6	binds	protein	0.70
Inflammation	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Ischemia	activates	disease	0.65
Cancer	activates	disease	0.65
Inflammation	regulates	disease	0.65
Als	expressed_in	disease	0.65
Diabetes	activates	disease	0.65
INFLAMMATION	activates	gene	0.60
Mapk	activates	pathway	0.60
MAPK3	activates	protein	0.60
MAPK1	activates	protein	0.60
RELA	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
NF-ΚB	expressed_in	gene	0.60
IL-6	activates	gene	0.60
INFLAMMATION	regulates	gene	0.60
PROINFLAMMATORY CYTOKINES	activates	gene	0.60
Nf-Κb	expressed_in	pathway	0.60
Microrna	activates	pathway	0.60

Incoming (9)

Source	Relation	Type	Str
TRIM21	interacts_with	protein	0.95
NLRP6	facilitates_degradation_via_TRIM21	protein	0.93
P38	inhibits	gene	0.60
MAPK	activates	gene	0.60
VIRAL INFECTIONS	activates	gene	0.60
CANCER	activates	gene	0.60
AND	causes	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
IRAK4	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TAB1 in their description or question text

No additional research found