protein

PRDX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRDX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

177Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Peroxiredoxin 1: antioxidant protein with crucial roles in oxidative stress defense, redox signaling, and neuroprotection in Alzheimer's and Parkinson's disease.

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🔬 Protein Info

Gene Symbol	PRDX1
Aliases	Peroxiredoxin 1
Function	Peroxiredoxin 1 is a ubiquitous antioxidant enzyme
Subcellular Localization	** \| Cytoplasm, nucleus, mitochondria \|
Molecular Weight	22 kDa
Amino Acids	199 aa
Pathways	GLYCOLYSIS
UniProt ID	PRDX1
Ensembl ID	ENSG00000117450
GeneCards	PRDX1
Human Protein Atlas	PRDX1
N-Terminal Resolving Cysteine (Cys52)	The first conserved cysteine that forms a disulfide bond with the C-terminal cysteine during the catalytic cycle. This residue is essential for peroxidase activity.
C-Terminal Resolving Cysteine (Cys173)	The second critical cysteine that forms an intersubunit disulfide bond in the dimeric protein. This forms the characteristic 2-Cys peroxiredoxin disulfide.
Active Site FVCP Motif (aa 49-52)	The conserved motif containing the N-terminal resolving cysteine. This motif is critical for nucleophilic attack on peroxides.
Thioredoxin Fold	The characteristic three-dimensional structure shared with thioredoxin and glutaredoxin families, providing the structural basis for redox activity.
Associated Diseases	Lymphoma, Tumor
Known Drugs/Compounds	Lipopolysaccharide, LPS
Interactions	AKT, AND, APOPTOSIS, ARHGEF2, AUTOPHAGY, BECN1
KG Connections	177 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PRDX1["PRDX1"] -->|"activates"| Ms["Ms"]
    PRDX1["PRDX1"] -->|"activates"| Als["Als"]
    PRDX1["PRDX1"] -->|"activates"| Cancer["Cancer"]
    PRDX1["PRDX1"] -->|"associated"| Lymphoma["Lymphoma"]
    PRDX1["PRDX1"] -->|"biomarker for"| Ms_1["Ms"]
    PRDX1["PRDX1"] -->|"associated"| Tumor["Tumor"]
    MOF["MOF"] -->|"regulates"| PRDX1["PRDX1"]
    LPS["LPS"] -.->|"inhibits"| PRDX1["PRDX1"]
    P38["P38"] -->|"activates"| PRDX1["PRDX1"]
    AKT["AKT"] -->|"activates"| PRDX1["PRDX1"]
    style PRDX1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (111)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PRDX1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Redox Signaling	involved_in	process	0.95
Inflammatory Macrophage Activation	mediates	process	0.90
Redox Signaling	regulates	process	0.90
ERK1/2	phosphorylates	protein	0.85
IL-6	upregulates	protein	0.85
Glycolysis	associated_with	pathway	0.85
Glycolysis	upregulates	pathway	0.85
DLBCL	biomarker_for	disease	0.80
Als	activates	disease	0.75
Autophagy	activates	pathway	0.70
ALS	regulates	disease	0.65
Ms	activates	disease	0.65
Infection	activates	disease	0.65
Cancer	inhibits	disease	0.65
ALS	activates	disease	0.65
Cancer	activates	disease	0.65
Lymphoma	associated_with	disease	0.65
Colorectal Cancer	inhibits	disease	0.65
Tumor	regulates	disease	0.65
Ms	biomarker_for	disease	0.65
Als	regulates	disease	0.65
Tumor	associated_with	disease	0.65
IL6	regulates	protein	0.64
HYDROGEN_PEROXIDE	regulates	protein	0.64
Ras	regulates	protein	0.60
Macrophage	activates	cell_type	0.60
Il-1	activates	protein	0.60
Fus	interacts_with	protein	0.60
Erk	activates	protein	0.60
IL-10	activates	gene	0.60
Myosin	regulates	protein	0.60
Interleukin	activates	protein	0.60
TLR4	activates	gene	0.60
ECSIT	activates	gene	0.60
AND	activates	gene	0.60
RELA	activates	gene	0.60
TAK1	activates	gene	0.60
Cell Cycle	associated_with	pathway	0.60
MAPK14	activates	gene	0.60
PRDX6	activates	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
IRF2BP2	interacts_with	gene	0.60
BECN1	activates	gene	0.60
TNF	activates	gene	0.60
CHUK	activates	gene	0.60
MAP3K7	activates	gene	0.60
TRAF6	activates	gene	0.60
SRXN1	biomarker_for	gene	0.60

Incoming (66)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PRDX1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
MOF	phosphorylates	enzyme	0.95
MOF	associated_with	enzyme	0.95
Lipopolysaccharide	modulates	compound	0.90
MOF	regulates	protein	0.72
AUTOPHAGY	activates	gene	0.70
LPS	inhibits	drug	0.64
UBIQUITIN	activates	gene	0.60
MAPK14	activates	gene	0.60
TNF	activates	gene	0.60
MAP3K7	activates	gene	0.60
LC3	activates	gene	0.60
BECN1	activates	gene	0.60
TRAF6	activates	gene	0.60
ECSIT	activates	gene	0.60
CHUK	activates	gene	0.60
IKBKB	activates	gene	0.60
IL6	activates	gene	0.60
PRDX6	activates	gene	0.60
RELA	activates	gene	0.60
TAK1	activates	gene	0.60
ARHGEF2	associated_with	entity	0.60
LMNA	associated_with	entity	0.60
NPM1	associated_with	entity	0.60
ACO1	biomarker_for	gene	0.60
LPIN1	biomarker_for	gene	0.60
MT1G	biomarker_for	gene	0.60
PEBP1	biomarker_for	gene	0.60
IL1B	activates	gene	0.60
TLR4	activates	gene	0.60
P38	activates	gene	0.60
AKT	activates	gene	0.60
LMNA	interacts_with	gene	0.60
NPM1	interacts_with	gene	0.60
TPM3	interacts_with	gene	0.60
ROS	activates	gene	0.60
IRF2BP2	interacts_with	gene	0.60
BRD4	biomarker_for	gene	0.60
ATM	biomarker_for	gene	0.60
PTEN	activates	gene	0.60
GPX4	activates	gene	0.60
AKT	phosphorylates	entity	0.60
ERK1	phosphorylates	entity	0.60
P38	phosphorylates	entity	0.60
ERK1	activates	gene	0.60
MTOR	biomarker_for	gene	0.60
MAP1LC3	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
FERROPTOSIS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRDX1 in their description or question text

No additional research found