concept

TAU PHOSPHORYLATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAU PHOSPHORYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

432Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	TAU PHOSPHORYLATION
Key Genes/Proteins	APOE, BDNF, CDK5, GLUT4
Related Diseases	ACETYLCHOLINE, ALZHEIMER'S DISEASE, AUTOPHAGY, CERAMIDE, DEMENTIA

Pathway Diagram

graph TD
    TAU_PHOSPHORYLATION["TAU PHOSPHORYLATION"]
    TAU_PHOSPHORYLATION -.biomarker for.-> Down_syndrome["Down syndrome"]
    TAU_PHOSPHORYLATION -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    Glucocorticoid_Receptor["Glucocorticoid Receptor"] -->|"regulates"| TAU_PHOSPHORYLATION
    Amyloid__["Amyloid-beta"] -->|"activates"| TAU_PHOSPHORYLATION
    phytochemicals["phytochemicals"] -->|"regulates"| TAU_PHOSPHORYLATION
    p38_MAPK["p38 MAPK"] -->|"activates"| TAU_PHOSPHORYLATION
    A_["Abeta"] -->|"activates"| TAU_PHOSPHORYLATION
    NPTX2["NPTX2"] -->|"target for"| TAU_PHOSPHORYLATION
    WIF1["WIF1"] -->|"target for"| TAU_PHOSPHORYLATION
    AMYLOID["AMYLOID"] -->|"regulates"| TAU_PHOSPHORYLATION
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| TAU_PHOSPHORYLATION
    AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"] -->|"expressed in"| TAU_PHOSPHORYLATION

Outgoing (54)

Target	Relation	Type	Str
TAU	modulates	protein	0.95
Microtubule Instability	causes	phenotype	0.90
Neurodegeneration	contributes_to	process	0.90
Alzheimer's Disease	contributes_to	disease	0.90
Alzheimer's Disease	associated_with	disease	0.90
tauopathies	causes	disease	0.90
Neurofibrillary Tangles	contributes_to	phenotype	0.85
Alzheimer's Disease	drives	disease	0.85
Neurodegeneration	contributes_to	process	0.85
Tau Aggregation	associated_with	process	0.85
Neuronal Degeneration	causes	process	0.85
Alzheimer's Disease	biomarker_for	disease	0.80
Alzheimer's Disease Neuropathology	contributes_to	mechanism	0.80
Alzheimer'S Disease	contributes_to	disease	0.80
Redox Imbalance	causes	process	0.75
neurodegeneration	causes	phenotype	0.70
Alzheimer's disease	biomarker_for	disease	0.70
Down syndrome	biomarker_for	disease	0.70
Alzheimer's disease	causes	disease	0.70
AUTOPHAGY	activates	phenotype	0.70
SNAP25	activates	gene	0.70
ACETYLCHOLINE	regulates	phenotype	0.65
AUTOPHAGY	phosphorylates	phenotype	0.65
NEURONS	interacts_with	cell_type	0.65
WNT PATHWAY	regulates	pathway	0.65
MAPK	inhibits	gene	0.65
AMYLOID-β	inhibits	concept	0.50
EMPAGLIFLOZIN	associated_with	drug	0.50
PREFRONTAL CORTEX	associated_with	brain_region	0.50
AMYGDALA	associated_with	brain_region	0.50
Neuron	associated_with	cell_type	0.50
GSK3	regulates	concept	0.50
AMYLOID-β	regulates	concept	0.50
Proteins	activates	protein	0.50
GLIOSIS	associated_with	concept	0.50
IPSC	expressed_in	concept	0.50
INSULIN	activates	concept	0.50
IPSC	inhibits	concept	0.50
VISUAL CORTEX	associated_with	brain_region	0.50
Microglia	associated_with	cell_type	0.50
Nlrp3 Inflammasome	activates	pathway	0.50
Nlrp3 Inflammasome	causes	pathway	0.50
LITHIUM	associated_with	drug	0.50
ORGANOIDS	associated_with	concept	0.50
Infection	associated_with	disease	0.50
INSULIN SIGNALING	associated_with	pathway	0.50
HIPPOCAMPUS	associated_with	brain_region	0.45
WNT PATHWAY	associated_with	pathway	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
MEMANTINE	associated_with	drug	0.45

Incoming (378)

Source	Relation	Type	Str
miR-219-5p	mediates	biomarker	0.95
R406	inhibits	drug	0.95
SYK	regulates	gene	0.95
Neddylation Inhibition	upregulates	mechanism	0.92
STING	activates	protein	0.92
24713000	is required for	paper	0.90
24713000	mediates	paper	0.90
ceramide	promotes	compound	0.90
Testosterone	inhibits	compound	0.90
Lumacaftor	inhibits	drug	0.90
miR-219-5p	activates	biomarker	0.90
BAY 61-3606	inhibits	drug	0.90
LARS2	inhibits	gene	0.90
35887339	decreased	paper	0.90
AMPK	promotes	protein	0.90
Ceramide	promotes	compound	0.90
41478829	competes with	paper	0.90
STING	upregulates	protein	0.90
TBK1	upstream_of	protein	0.88
PKR	mediates	protein	0.88
PP2A	downregulates	protein	0.85
LRRK2	associated_with	protein	0.85
Chronic Sleep Deprivation	causes	process	0.85
TTBK1	involved_in	enzyme	0.85
GMPR1	associated_with	protein	0.85
GSK3B	mediates	protein	0.85
MAPK14	mediates	protein	0.85
Lipopolysaccharide	associated_with	compound	0.85
Amyloid-β	associated_with	compound	0.85
GSK-3β	involved_in	enzyme	0.85
TYROBP	regulates	protein	0.85
NLRP3 Inflammasome	mediates	pathway	0.85
TBK1	mediates	protein	0.85
Brain Cholesterol Accumulation	promotes	phenotype	0.85
Oxidative Stress	upregulates	process	0.80
NF-κB	modulates	protein	0.80
Hyperbaric Oxygen Therapy	inhibits	drug	0.80
MIR-125B	upregulates	gene	0.80
MIR-212	inhibits	gene	0.80
Abeta	contributes_to	compound	0.80
Rg1	inhibits	compound	0.80
BDNF	disrupts	gene	0.80
MIR-132	inhibits	gene	0.80
GSK3B	upregulates	protein	0.80
GMPR	modulates	gene	0.80
neurons	activates	cell_type	0.80
amyloid-beta	promotes	protein	0.80
miR-206-3p	associated_with	compound	0.75
Glucocorticoid Receptor	regulates	receptor	0.75
TAU	causes	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Variant Annotation and Prioritization of AD Risk Loci

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.862

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

neurodegeneration | 2026-04-15 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Which non-coding variants at AD GWAS loci have functional evidence for gene regu

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Does the BIN1 non-coding variant mechanism provide a druggable target, or is tra

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

The abstract shows that Gal3 binding to pTau greatly enhances tau fibrillation,

closed · Rounds: 4 · Score: 0.92 · 2026-04-16

Related Research

Hypotheses and analyses mentioning TAU PHOSPHORYLATION in their description or question text

No additional research found