gene 1,381 words KG: MAPK14
Contents

MAPK14 — Mitogen-Activated Protein Kinase 14 (p38α)

🧬 Gene Info
Gene SymbolMAPK14
Full NameMitogen-Activated Protein Kinase 14 (p38α)
Chromosome6p21.3
Protein TypeSerine/Threonine Kinase
Functionis a serine/threonine kinase belonging to the MAPK family.
Molecular Weight41 kDa
Amino Acids360 aa
PathwaysMAPK, TGF-β
UniProt ID[Q16539](https://www.uniprot.org/uniprot/Q16539)
Ensembl IDENSG00000166401
OMIM600289
GeneCardsMAPK14
Human Protein AtlasMAPK14
Associated DiseasesAging, Als, Cancer, Cardiovascular, Ischemia, Ms
Known Drugs/CompoundsLosmapimod, rapamycin
InteractionsAIFM1, AKT1, AKT1S1, ALZHEIMER, AMBRA1, AMPK
KG Connections729 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

Noradrenergic-Tau Propagation Blockade
Score: 0.71
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57

Related Analyses (5)

What is the therapeutic window between insufficient and toxi
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (3)

GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92
MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (11)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: interacts_with
ADRA2A Gene
gene · KG edge: associated_with
adra2b Gene
gene · KG edge: associated_with
AIFM1 Gene
gene · KG edge: activates
AKT1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

OPTN interacts_with MAPK14
CASP3 interacts_with MAPK14
AKT1 interacts_with MAPK14
CALCOCO2 interacts_with MAPK14
CGAS interacts_with MAPK14
CFTR interacts_with MAPK14
SQSTM1 interacts_with MAPK14
RPS6KB1 interacts_with MAPK14
GRB2 interacts_with MAPK14
RHEB interacts_with MAPK14

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