Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TDP-43 Phosphorylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| p38α MAPK inhibition | reduces | process | 1.00 |
| MAPK14 | phosphorylates | gene | 0.95 |
| 14-3-3θ | mediates | protein | 0.85 |
| YWHAQ | promotes | protein | 0.85 |
| stress kinases | activates | pathway | 0.70 |
| mitochondrial dysfunction | causes | mechanism | 0.70 |
| mitochondrial dysfunction | activates | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| p38α Inhibitor and PRMT1 Activator Combination to Restore Ph | 0.879 | neurodegeneration | What is the therapeutic window between i |
| Aβ42 oligomers drive TDP-43 phosphorylation at s409/410 thro | 0.595 | neurodegeneration | What mechanisms drive TDP-43 pathology s |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.580
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| MAPK pathway inhibition by QTJD through butyrate mechanism | exploratory | Mycoplasma pneumoniae pneumoni | 0.900 | 0.00 | Mouse macrophages | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning TDP-43 Phosphorylation in their description or question text
No additional research found