gene

TRIM16

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

25Outgoing

4Incoming

0Experiments

0Debates

Summary

TRIM16 (Tripartite Motif-containing 16) is a member of the TRIM family with E3 ubiquitin ligase activity. It plays critical roles in autophagy regulation, oxidative stress response, and neuroprotection against protein aggregation in neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	TRIM16
Full Name	Tripartite Motif-Containing Protein 16
Aliases	Tripartite Motif-containing 16
Chromosome	17p12
Function	TRIM16 possesses multiple functional domains that mediate its diverse cellular roles:
Amino Acids	640 aa
Pathways	Autophagy
UniProt ID	Q9Y2H9
NCBI Gene ID	10678
Ensembl ID	ENSG00000131865
OMIM	609678
GeneCards	TRIM16
Human Protein Atlas	TRIM16
Cargo recognition	Binds to ubiquitinated protein aggregates
Autophagosome formation	Recruits autophagy machinery to aggregate-prone proteins
Associated Diseases	Aging, Carcinoma, Tumor
Interactions	APOPTOSIS, GBM, OPTN
KG Connections	29 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRIM16 — AlphaFold Q9Y2H9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TRIM16 — Tripartite Motif-Containing Protein 16

gene · 629 words

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Pathway Diagram

graph TD
    TRIM16["TRIM16"]
    Autophagy_Pathway["Autophagy Pathway"]
    LC3B["LC3B"]
    Apoptosis_Pathway["Apoptosis Pathway"]
    MAPK_Pathway["MAPK Signaling"]
    ERK2["ERK2/MAPK1"]
    MAPK3["MAPK3"]
    PI3K["PI3K"]
    STAT3["STAT3"]
    IL6["IL6"]
    FGF2["FGF2"]
    Aging["Aging"]
    Neurodegeneration["Neurodegeneration"]
    Tumor_Microenv["Tumor Microenvironment"]
    Cancer["Cancer"]

    TRIM16 -->|"regulates"| Autophagy_Pathway
    TRIM16 -->|"expressed_in"| LC3B
    LC3B -->|"promotes"| Autophagy_Pathway
    
    TRIM16 -->|"activates"| Apoptosis_Pathway
    
    TRIM16 -->|"implicated_in"| MAPK_Pathway
    MAPK_Pathway -->|"includes"| ERK2
    MAPK_Pathway -->|"includes"| MAPK3
    
    TRIM16 -->|"interacts_with"| PI3K
    TRIM16 -->|"interacts_with"| STAT3
    TRIM16 -->|"interacts_with"| IL6
    TRIM16 -->|"interacts_with"| FGF2
    
    TRIM16 -->|"implicated_in"| Aging
    Aging -->|"contributes_to"| Neurodegeneration
    
    TRIM16 -->|"regulates"| Cancer
    TRIM16 -->|"involved_in"| Tumor_Microenv

    style TRIM16 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Autophagy_Pathway fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style LC3B fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style Apoptosis_Pathway fill:#ef5350,stroke:#f44336,stroke-width:2px
    style ERK2 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style MAPK3 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style PI3K fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style STAT3 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style IL6 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style FGF2 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style Aging fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style Neurodegeneration fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style Cancer fill:#7d4200,stroke:#ff9800,stroke-width:2px

Outgoing (25)

Target	Relation	Type	Str
Tumor	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Carcinoma	implicated_in	disease	0.65
Tumor	implicated_in	disease	0.65
Cancer	regulates	disease	0.65
Aging	implicated_in	disease	0.65
Autophagy	regulates	pathway	0.60
Mapk	implicated_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
Tumor Microenvironment	implicated_in	pathway	0.60
CANCER	regulates	gene	0.60
LC3B	expressed_in	gene	0.60
AUTOPHAGY	regulates	gene	0.60
STAT3	implicated_in	gene	0.60
PI3K	implicated_in	gene	0.60
FGF2	implicated_in	gene	0.60
IL6	implicated_in	gene	0.60
MAPK1	implicated_in	gene	0.60
APOPTOSIS	activates	gene	0.60
ERK2	implicated_in	gene	0.60
Apoptosis	activates	pathway	0.60
MAPK3	implicated_in	gene	0.60
glioblastoma	activates	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60

Incoming (4)

Source	Relation	Type	Str
ERK1	implicated_in	gene	0.60
LC3B	expressed_in	gene	0.60
OPTN	activates	gene	0.60
GBM	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRIM16 in their description or question text

No additional research found