gene 1,629 words KG: MAPK10
Contents

MAPK10 Gene

🧬 Gene Info
Gene SymbolMAPK10
AliasesMitogen-Activated Protein Kinase 10
Chromosome5q36.3
Protein FamilyMAPK family, JNK subfamily
Protein TypeSerine/Threonine Kinase
FunctionRegulatory and interaction domains
Primary Expressionthe central nervous system and plays critical roles in stress responses, neuronal apoptosis, synaptic plasticity, and neurodegeneration
Molecular Weight52 kDa
Amino Acids464 aa
Exons21
PathwaysMAPK
NCBI Gene ID5602
GeneCardsMAPK10
Human Protein AtlasMAPK10
Genomic positionApproximately 179,500,000-179,600,000 (GRCh38)
Associated Diseasesneurodegeneration
InteractionsAPOPTOSIS, AR, CNR1, FERROPTOSIS, GENES, GRIK1
KG Connections54 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

JAK Inhibitors in Parkinson's Disease
company · KG edge: therapeutic_target
Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: activates
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

MAPK10 therapeutic_target APOE
MAPK10 associated_with SIGLEC1
MAPK10 therapeutic_target SPR
SIGLEC1 associated_with MAPK10
SPR therapeutic_target MAPK10
APOE therapeutic_target MAPK10
JNK activates MAPK10
MAPK10 activates JNK3
GLUL targets MAPK10
MAPK10 targets MAPT

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