gene 866 words KG: MAPK1
Contents

MAPK1 Gene

🧬 Gene Info
Gene SymbolMAPK1
Protein FamilyMAP kinase family, CMGC group
Protein TypeKinase
Functionis a protein involved in various cellular processes relevant to neurodegeneration.
Subcellular LocalizationCytoplasm, nucleus
Molecular Weight41 kDa
Amino Acids360 aa
PathwaysMAPK, Mapk, MAPK signaling, MAPK pathway
UniProt IDP28482
GeneCardsMAPK1
Human Protein AtlasMAPK1
Associated DiseasesAging, Als, Alzheimer, Cancer, Carcinoma
Known Drugs/CompoundsChrysotoxine, DEP, DMP, DOP, Zuojin Pill
InteractionsACTB, ACTG1, Actin, ACVR1, AIFM1, AKT
KG Connections889 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (16)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Retinal Vascular Microcirculation Rescue
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57

Related Analyses (7)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (3)

GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92
MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (6)

ACTB Gene
gene · KG edge: associated_with
ACTG1 Gene
gene · KG edge: interacts_with
ACVR1 Gene
gene · KG edge: interacts_with
AIFM1 Gene
gene · KG edge: activates
AKT1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

FOXO3 inhibits MAPK1
PI3K inhibits MAPK1
MAPK1 inhibits MAP1LC3B
MAPK1 inhibits MTOR
MAPK1 inhibits TLR4
MAPK1 inhibits LC3
APP activates MAPK1
MAPK1 activates TFEB
MAPK1 activates AKT
NFKB1 therapeutic_target MAPK1

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