| Gene Symbol | MAPK11 |
| Full Name | Mitogen-Activated Protein Kinase 11 |
| Aliases | Mitogen-activated protein kinase 11 (p38β) |
| Chromosome | 22q12.1 |
| Function | is a major signaling cascade activated by cellular stress and pro-inflammatory cytokines. |
| Subcellular Localization | </b></td><td>Cytoplasm, Nucleus</td></tr> |
| Molecular Weight | 41 kDa |
| Pathways | MAPK, MAPK pathway |
| UniProt ID | [Q16643](https://www.uniprot.org/uniprot/Q16643) |
| GeneCards | MAPK11 |
| Human Protein Atlas | MAPK11 |
| Kinase domain | Classic bilobal kinase structure with activation loop containing the dual phosphorylation motif (Thr180/Tyr182) |
| DGF motif | Asp-Phe-Gly sequence in subdomain VII critical for catalysis |
| Common docking domain | Surface region for substrate and regulator binding |
| CD domain | C-terminal common docking site for MAP kinase phosphatases and upstream activators[@kuma2005] |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Neuroinflammation, Stroke |
| Known Drugs/Compounds | Losmapimod |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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