gene 949 words KG: ERK2
Contents

ERK2 (MAPK1)

🧬 Gene Info
Gene SymbolMAPK1
Full NameMitogen-Activated Protein Kinase 1
AliasesERK2
Chromosome22q11.22
Protein TypeKinase
Functionis a serine/threonine protein kinase that serves as a central mediator of intracellular signal transduction.
Molecular Weight42 kDa
Amino Acids360 aa
PathwaysMAPK, Mapk, MAPK signaling
UniProt IDP28482
NCBI Gene ID5594
Ensembl IDENSG00000100030
GeneCardsMAPK1
Human Protein AtlasMAPK1
Associated DiseasesAging, Als, Cancer, Carcinoma, Heart Failure, Melanoma
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, ATF4
KG Connections168 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40

See Also (15)

ATP P2X3 Receptor Neurons
cell · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ATF4 Gene
gene · KG edge: activates
BAX Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PRDX1 regulates ERK2
ERK2 activates DRP1
DRP1 activates ERK2
ERK2 activates ATF4
ERK2 activates TFAM
ERK2 activates BCL2
ERK2 activates BAX
ERK2 activates ERK1
TNF associated_with ERK2
ERK1 associated_with ERK2

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