| Gene Symbol | MAPK12 |
| Aliases | p38-gamma, ERK6, SAPK3 |
| Chromosome | 22q13.1 |
| Protein Type | Kinase |
| Function | MAPK12 participates in multiple cellular signaling pathways |
| Primary Expression | various tissues, with particularly high expression in skeletal muscle and brain, where it regulates diverse cellular processes including cell differen |
| Molecular Weight | 42 kDa |
| Amino Acids | 182 aa |
| Pathways | Mapk, MAPK, mapk, MAPK pathway |
| GeneCards | MAPK12 |
| Human Protein Atlas | MAPK12 |
| Stress-Activated Kinase Pathway | MAPK12 is activated by cellular stresses including UV radiation, oxidative stress, and inflammatory cytokines (TNF-α, IL-1). |
| Cell Differentiation | MAPK12 plays roles in muscle cell differentiation and neuronal development. |
| Synaptic Plasticity | In neurons, MAPK12 is involved in regulating synaptic strength and plasticity, processes critical for learning and memory. |
| Inflammatory Responses | MAPK12 contributes to the production of inflammatory mediators in glial cells. |
| Associated Diseases | neurodegeneration |
| Interactions | App |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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