protein 1,093 words KG: LRP2PROTEIN
Contents

LRP2 Protein - Megalin

🔬 Protein Info
Gene SymbolLRP2
Full NameLRP2 (Megalin)
AliasesPage for LRP2 Protein, Megalin
Chromosome2q31.1
Protein TypeProtein
Functionis a giant multiligand endocytic receptor of the LDL receptor family with high physiological relevance at epithelial interfaces, including the choroid plexus and brain barriers.
Molecular Weight600 kDa
Amino Acids630 aa
Exons79
PathwaysAngiogenesis, Apoptosis, Autophagy, Lipid Metabolism, Mtor
UniProt IDSearch UniProt
GeneCardsLRP2
Human Protein AtlasLRP2
Associated DiseasesAD, ADH, Aging, Als, AMI
Known Drugs/Compoundsrapamycin
InteractionsAMPK, AND, APOPTOSIS, ATG, ATP, CANCER
KG Connections263 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (12)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
nct05508789
clinical_trial · Pages share 4 hypotheses
MK-1167 Phase 2 AD Trial (MK-1167-008)
clinical · Pages share 4 hypotheses
A Placebo-Controlled, Double-Blind, Parallel-Group, 18-
clinical · Pages share 4 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 4 hypotheses

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