concept

NEUROGENESIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROGENESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1306Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

13Experiments

0Debates

Summary

NEUROGENESIS is a concept in neurodegeneration research. Key relationships include: promotes, co discussed, inhibits. Associated with ALZHEIMER'S, DEPRESSION, NEURODEGENERATION. Connected to 29 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NEUROGENESIS
Key Genes/Proteins	ALPHA-SYNUCLEIN, AMYLOID, AMYLOID-BETA, APOE, APP, AQP4
Related Diseases	ALZHEIMER, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Neurogenesis

cell · 3757 words

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Pathway Diagram

graph TD
    NEUROGENESIS["NEUROGENESIS"]
    NEUROGENESIS -->|"expressed in"| hippocampus["hippocampus"]
    NEUROGENESIS -->|"interacts"| Notch["Notch"]
    NEUROGENESIS -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    NEUROGENESIS -->|"interacts"| Mitochondrial_Function["Mitochondrial Function"]
    NEUROGENESIS -->|"interacts"| Angiogenesis["Angiogenesis"]
    NEUROGENESIS -->|"interacts"| Apoptosis["Apoptosis"]
    NEUROGENESIS -->|"interacts"| Complement["Complement"]
    NEUROGENESIS -->|"interacts"| Nf__b["Nf-Kappab"]
    FIP200["FIP200"] -->|"regulates"| NEUROGENESIS
    GFAP["GFAP"] -->|"inhibits"| NEUROGENESIS
    curcumin["curcumin"] -->|"activates"| NEUROGENESIS
    BDNF["BDNF"] -->|"activates"| NEUROGENESIS
    BMAL1["BMAL1"] -->|"activates"| NEUROGENESIS
    gut_microbiota["gut microbiota"] -->|"regulates"| NEUROGENESIS

Outgoing (234)

Target	Relation	Type	Str
NEURON	associated_with	cell_type	0.95
NEURON	activates	cell_type	0.95
Post-Traumatic Brain Injury	involved_in	disease	0.88
COGNITIVE DECLINE	exacerbates	phenotype	0.70
VEGF	regulates	gene	0.70
Major Depressive Disorder	associated_with	disease	0.70
DENTATE GYRUS	activates	brain_region	0.70
NEURAL STEM CELLS	activates	cell_type	0.70
Alzheimer's Disease	involved_in	disease	0.70
NEURONS	protects_against	cell_type	0.70
hippocampus	expressed_in	brain_region	0.70
major depressive disorder	implicated_in	disease	0.70
ASTROCYTES	treats	cell_type	0.65
NRF2	causes	gene	0.65
CYTOKINES	inhibits	phenotype	0.65
IL1B	interacts_with	gene	0.65
ISCHEMIA	regulates	disease	0.65
INTERNEURONS	produces	cell_type	0.65
INFLAMMATION	activates	phenotype	0.65
MICROGLIA	treats	cell_type	0.65
MAPK	regulates	gene	0.65
MAPK	inhibits	gene	0.65
HIPPOCAMPUS	targets	brain_region	0.65
SIRT3	treats	gene	0.65
MICROGLIAL ACTIVATION	causes	phenotype	0.65
NEURON	regulates	cell_type	0.65
MICROGLIA	biomarker_for	cell_type	0.65
STROKE	treats	disease	0.65
AUTOPHAGY	produces	phenotype	0.65
EPILEPSY	activates	disease	0.65
NPY	activates	gene	0.60
TRKB	activates	gene	0.60
neuroinflammation	regulates	process	0.60
SNCA	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
PP2A	associated_with	gene	0.60
SYNGAP1	binds_to	gene	0.60
INTERNEURONS	stabilizes	cell_type	0.60
ALZHEIMER'S DISEASE	depleted_in	disease	0.60
SYNCRIP	binds_to	gene	0.60
SOX2	associated_with	gene	0.60
oxidative stress	associated_with	process	0.60
oxidative stress	activates	process	0.60
RNA	binds_to	gene	0.60
synaptic plasticity	inhibits	process	0.60
Nf-Κb	interacts_with	pathway	0.55
Complement	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Angiogenesis	interacts_with	pathway	0.55
Mitochondrial Function	interacts_with	pathway	0.55

Incoming (1072)

Source	Relation	Type	Str
Neurodegeneration	activates	disease	1.00
Inflammation	activates	disease	1.00
BDNF	activates	gene	1.00
Als	activates	disease	1.00
BDNF	activates	protein	1.00
OXIDATIVE STRESS	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
Neuroinflammation	activates	disease	1.00
CYTOKINES	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
Depression	activates	disease	1.00
DEPRESSION	activates	gene	1.00
HIPPOCAMPUS	regulates	brain_region	0.95
NPY	promotes	protein	0.95
HIPPOCAMPUS	associated_with	brain_region	0.95
WNT	regulates	pathway	0.95
Exercise Training	promotes	process	0.92
BDNF	promotes	protein	0.90
FIP200	regulates	protein	0.90
Notch Signaling	inhibits	pathway	0.90
Exercise	upregulates	process	0.90
Adult Neural Stem Cells	involved_in	cell_type	0.90
AdipoRon	associated_with	drug	0.90
TNF	activates	gene	0.90
Tumor	activates	disease	0.90
Als	associated_with	disease	0.90
Aging	activates	disease	0.90
NEUROINFLAMMATION	activates	gene	0.90
Neurodegeneration	associated_with	disease	0.90
NEURODEGENERATION	associated_with	gene	0.90
SOX2	associated_with	gene	0.88
Itaconate	promotes	compound	0.88
Microglia Activation	regulates	process	0.85
HDAC3	modulates	gene	0.85
PI3K/AKT pathway	regulates	pathway	0.85
PI3K/AKT	regulates	pathway	0.85
Aβ42	modulates	biomarker	0.85
MT2	involved_in	protein	0.85
MT1	involved_in	protein	0.85
SIRT1	regulates	protein	0.85
Apbb1Ip	biomarker_for	biomarker	0.85
USP9X	promotes	gene	0.85
USP9X	involved_in	gene	0.85
Oxytocin	associated_with	drug	0.85
Α-SYNUCLEIN	inhibits	protein	0.85
METALLOTHIONEIN-I+II	associated_with	protein	0.85
Alzheimer's Disease	inhibits	disease	0.85
Gut Microbiota	promotes	cell_type	0.82
Microglia	regulates	cell_type	0.80

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.820	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hypocretin-Neurogenesis Coupling Therapy	0.688	neurodegeneration	Sleep disruption as cause and consequenc
HBOT at 2.0 ATA for 60 min, 5x/week for 6 weeks enhances hip	0.450	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (13)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Spp1 knockout prevents synaptic loss in AD mouse models	validation	Alzheimer's disease	0.900	0.00	Spp1 knockout AD mouse models	proposed	N/A
Synaptic plasticity and protein expression analysis in mPFC	exploratory	insomnia-anxiety comorbidity	0.850	0.00	mPFC brain slices from PCPA-tr	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Animal Model Comparison for Neurodegenerative Disease Therapeutics	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,100,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
Brainstem Circuit Modulation for PSP	clinical	ALS	0.400	0.50	human	proposed	$5,460,000
Neural Stem Cell Therapy for Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Sleep and Respiratory Network Interaction in ALS — Experiment Design	clinical	ALS	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
EMI1 switches from being a substrate to an inhibitor of APC/C(CDH1) to start the [PMID:29875408]	Cappell SD, Mark KG, Garbett D, Pack LR,	Nature	2018	1
Metabolic fate of glucose and candidate signaling and excess-fuel detoxification [PMID:28280244]	Mugabo Y, Zhao S, Lamontagne J, Al-Mass	J Biol Chem	2017	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitoch [PMID:19879861]	Xu S, Zhou Z, Zhang L, Yu Z, Zhang W, Wa	Brain Res	2010	1
Nucleotide signaling and cutaneous mechanisms of pain transduction. [PMID:19171165]	Dussor G, Koerber HR, Oaklander AL, Rice	Brain Res Rev	2009	1
Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863]	Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D	Brain research bulletin	2026	0
Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465]	Kwon H, Seo DS, Ahmad Y, Park S, Yoo J,	The Journal of nutritional bio	2026	0
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794]	Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY,	Molecular psychiatry	2026	0
The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799]	Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK	Brain and behavior	2026	0
Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830]	Kang J, Son Y, Yim Y, Cho H, Kim J et al	J Adv Res	2026	0
Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheime [PMID:41370943]	Xu J, He Z, Pan Y, Cao B, Chen G	Biomater Adv	2026	0
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neu [PMID:41554641]	Zhang K, Zhu S, Xing N, Zhou Z, Chen J e	Br J Pharmacol	2026	0
Postbiotics and the gut-brain axis: A mechanistic review on modulating neuroinfl [PMID:41570486]	Lahariya R, Anand G, Kumari B, Priyadars	J Neuroimmunol	2026	0
miRNA-206 in muscle and central nervous system crosstalk during exercise: A doub [PMID:41571168]	Malvandi AM, Gerosa L, Maroni P, Orlando	Neurosci Biobehav Rev	2026	0
Experts' narrative review "Mastication, Hippocampal Structure Changes and Cognit [PMID:41576846]	Piancino MG	Arch Oral Biol	2026	0
Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917]	Xue D, Hu X, Li R, Sun T, Qian S et al.	Phytomedicine	2026	0
Dysregulation of Drp1 and Mfn2 is associated with reduced PSD-95, synaptophysin, [PMID:41932483]	Alfateh M, Vasconcelos C, Choker AH, Moh	Int J Biol Macromol	2026	0
AICAR improves depression-like behaviors and is associated with hippocampal AMPK [PMID:41932583]	Takahashi K, Kurokawa K, Kawaguchi R, Ta	Neurochem Int	2026	0
Human umbilical cord mesenchymal stem cells therapy for Alzheimer's disease: a s [PMID:41847685]	Si C, Ma L, Ding W, Tian Y, Zhang J, Cao	Frontiers in neurology	2026	0
Cannabidiol and pBDNF Cotreatment Attenuates Pathological Symptoms and Improves [PMID:41924980]	Chaulagain B, Gothwal A, Mahanta AK, Jar	ACS chemical neuroscience	2026	0

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning NEUROGENESIS in their description or question text

No additional research found