gene

LRP8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

191Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

LRP8 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Aging, Als. Connected to 66 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LRP8
Chromosome	1p31.3
Protein Type	Receptor
Function	Neuronal migration: Reelin-LRP8/Dab1 signaling regulates cortical lamination
Amino Acids	870 aa
Exons	31
Pathways	Cardiovascular Homeostasis
Ensembl ID	ENSG00000157193
GeneCards	LRP8
Human Protein Atlas	LRP8
NPxY motifs	Two motifs for endocytosis and signaling
Phosphorylation sites	Regulate protein interactions
Associated Diseases	Aging, Als, Alzheimer, Atherosclerosis, Cancer
Interactions	ABCA1, abca2, ABCA2, AGING, AKT, APOA1
KG Connections	191 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LRP8 Gene

gene · 891 words

→

LRP8 (ApoER2) Protein

protein · 785 words

→

Pathway Diagram

graph TD
    LRP8["LRP8"]
    Cancer{"Cancer"}
    LRP8 -->|"associated with"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    LRP8 -->|"associated with"| Neurodegeneration
    Cardiovascular{"Cardiovascular"}
    LRP8 -->|"associated with"| Cardiovascular
    Als{"Als"}
    LRP8 -->|"associated with"| Als
    Aging{"Aging"}
    LRP8 -->|"associated with"| Aging
    Hypertension{"Hypertension"}
    LRP8 -->|"associated with"| Hypertension
    Atherosclerosis{"Atherosclerosis"}
    LRP8 -->|"associated with"| Atherosclerosis
    Stroke{"Stroke"}
    LRP8 -->|"associated with"| Stroke
    Ms{"Ms"}
    LRP8 -->|"associated with"| Ms
    Heart_Failure{"Heart Failure"}
    LRP8 -->|"associated with"| Heart_Failure
    Ftd{"Ftd"}
    LRP8 -->|"associated with"| Ftd
    ALS{"ALS"}
    LRP8 -->|"associated with"| ALS
    LRP1B["LRP1B"]
    LRP1B -->|"associated with"| LRP8
    PAH["PAH"]
    PAH -->|"associated with"| LRP8
    LRP4["LRP4"]
    LRP4 -->|"associated with"| LRP8
    LDLR["LDLR"]
    LDLR -->|"associated with"| LRP8
    LRP5["LRP5"]
    LRP5 -->|"associated with"| LRP8
    LRP1["LRP1"]
    LRP1 -->|"associated with"| LRP8
    LDL["LDL"]
    LDL -->|"associated with"| LRP8
    STROKE["STROKE"]
    STROKE -->|"associated with"| LRP8
    LRP2["LRP2"]
    LRP2 -->|"associated with"| LRP8
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"associated with"| LRP8
    CANCER["CANCER"]
    CANCER -->|"associated with"| LRP8
    REELIN["REELIN"]
    REELIN -->|"associated with"| LRP8
    style LRP8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (131)

Target	Relation	Type	Str
calcium flux	mediates	process	0.90
HIPPOCAMPUS	binds_to	cell_type	0.80
Alzheimer's Disease	therapeutic_target	disease	0.80
Als	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
Atherosclerosis	degrades	disease	0.65
Cardiovascular	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Heart Failure	associated_with	disease	0.65
Hypertension	activates	disease	0.65
Atherosclerosis	transports	disease	0.65
Alzheimer	transports	disease	0.65
ALS	transports	disease	0.65
Atherosclerosis	activates	disease	0.65
Heart Failure	activates	disease	0.65
Cancer	activates	disease	0.65
Cancer	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Atherosclerosis	regulates	disease	0.65
ALS	associated_with	disease	0.65
Aging	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Ftd	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.60
MAPT	regulates	gene	0.60
LRP1	regulates	gene	0.60
LIPA	regulates	gene	0.60
APP	regulates	gene	0.60
APOE	activates	gene	0.60
CYP46A1	activates	gene	0.60
ABCA1	activates	gene	0.60
NCSTN	regulates	gene	0.60
GSK3B	regulates	gene	0.60
PSEN1	regulates	gene	0.60
SREBF1	regulates	gene	0.60
APOC1	activates	gene	0.60
APOC2	activates	gene	0.60
SOAT1	activates	gene	0.60
ABCA2	activates	gene	0.60

Incoming (60)

Source	Relation	Type	Str
APOE	binds	gene	0.95
APP	binds	gene	0.90
RLN	binds	gene	0.90
amyloid beta	antagonizes	compound	0.85
APOE4	inhibits	protein	0.85
APOE3	activates	protein	0.85
WNT	associated_with	gene	0.60
APOD	activates	gene	0.60
ALZHEIMER	degrades	gene	0.60
LRP2	associated_with	gene	0.60
REELIN	associated_with	gene	0.60
PAH	activates	gene	0.60
AGING	associated_with	gene	0.60
APOER2	associated_with	gene	0.60
CH25H	activates	gene	0.60
TFCP2	regulates	gene	0.60
SREBF1	degrades	gene	0.60
LDL	associated_with	gene	0.60
STROKE	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AND	associated_with	gene	0.60
LRP1	associated_with	gene	0.60
LRP1B	associated_with	gene	0.60
PAH	associated_with	gene	0.60
LRP4	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
LRP5	associated_with	gene	0.60
APOE	transports	gene	0.60
NCSTN	regulates	gene	0.60
PSEN2	regulates	gene	0.60
LIPA	transports	gene	0.60
LDLR	transports	gene	0.60
ABCA1	transports	gene	0.60
GSK3B	regulates	gene	0.60
APP	regulates	gene	0.60
ABCA2	activates	gene	0.60
APOC1	activates	gene	0.60
APOC2	activates	gene	0.60
APOC3	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
EXERCISE	associated_with	gene	0.60
LDLR	expressed_in	gene	0.60
PI3K	activates	gene	0.60
BDNF	activates	gene	0.60
LRP1	co_expressed_with	gene	0.50
apoc1	activates	gene	0.50
apoc2	activates	gene	0.50
apoc3	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LRP8 in their description or question text

No additional research found