gene

LRP5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

119Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

0Experiments

0Debates

Summary

LRP5 gene page for neurodegenerative disease research

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🧬 Gene Info

Gene Symbol	LRP5
Aliases	Page for LRP5 Protein
Protein Type	Receptor
Function	Wnt Binding: LRP5 binds Wnt ligands (Wnt1, Wnt3, Wnt3a) in conjunction with Frizzled receptors
Primary Expression	the central nervous system where it plays important roles in neuronal development, synaptic plasticity, and cognitive function[@gong2001]
Molecular Weight	179 kDa
Amino Acids	1615 aa
Pathways	Wnt, Wnt signaling, Wnt Signaling
UniProt ID	[O75177](https://www.uniprot.org/uniprot/O75177)
Ensembl ID	ENSG00000162337
GeneCards	LRP5
Human Protein Atlas	LRP5
Osteoblast Function	Promotes osteoblast differentiation and activity
Bone Mass	Gain-of-function mutations cause high bone mass
Calcium Homeostasis	Regulates intestinal calcium absorption
Associated Diseases	Aging, Als, Atherosclerosis, Autosomal Dominant Polycystic Kidney Diseases, Autosomal Dominant Polycystic Liver Diseases
Interactions	Actin, AMYLOID, APOE, APOE3, APOE4, App
KG Connections	119 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LRP5["LRP5"]
    Cancer{"Cancer"}
    LRP5 -->|"associated with"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    LRP5 -->|"associated with"| Neurodegeneration
    Cardiovascular{"Cardiovascular"}
    LRP5 -->|"associated with"| Cardiovascular
    Als{"Als"}
    LRP5 -->|"associated with"| Als
    Aging{"Aging"}
    LRP5 -->|"associated with"| Aging
    Hypertension{"Hypertension"}
    LRP5 -->|"associated with"| Hypertension
    Atherosclerosis{"Atherosclerosis"}
    LRP5 -->|"associated with"| Atherosclerosis
    Stroke{"Stroke"}
    LRP5 -->|"associated with"| Stroke
    Ms{"Ms"}
    LRP5 -->|"associated with"| Ms
    Heart_Failure{"Heart Failure"}
    LRP5 -->|"associated with"| Heart_Failure
    LRP5 -->|"regulates"| Atherosclerosis
    LRP5 -->|"regulates"| Cardiovascular
    LRP8["LRP8"]
    LRP8 -->|"associated with"| LRP5
    LRP1B["LRP1B"]
    LRP1B -->|"associated with"| LRP5
    PAH["PAH"]
    PAH -->|"associated with"| LRP5
    LRP4["LRP4"]
    LRP4 -->|"associated with"| LRP5
    LDLR["LDLR"]
    LDLR -->|"associated with"| LRP5
    LRP6["LRP6"]
    LRP6 -->|"associated with"| LRP5
    LRP1["LRP1"]
    LRP1 -->|"associated with"| LRP5
    LRP2["LRP2"]
    LRP2 -->|"associated with"| LRP5
    LDL["LDL"]
    LDL -->|"associated with"| LRP5
    STROKE["STROKE"]
    STROKE -->|"associated with"| LRP5
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"associated with"| LRP5
    CANCER["CANCER"]
    CANCER -->|"associated with"| LRP5
    style LRP5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (87)

Target	Relation	Type	Str
Familial Exudative Vitreoretinopathy	associated_with	disease	0.80
Reck	binds	protein	0.80
Wnt7	binds	protein	0.80
Autosomal Dominant Polycystic Kidney Diseases	associated_with	disease	0.70
Autosomal Dominant Polycystic Liver Diseases	associated_with	disease	0.70
Gpr124	interacts_with	protein	0.70
Cardiovascular	activates	disease	0.65
Hypertension	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Cardiovascular	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	associated_with	disease	0.65
Heart Failure	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Ftd	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Heart Failure	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
ALS	regulates	disease	0.65
Als	associated_with	disease	0.65
stem cells	expressed_in	cell_type	0.60
LRP1	associated_with	gene	0.60
LRP2	associated_with	gene	0.60
LRP1B	associated_with	gene	0.60
LRP4	associated_with	gene	0.60
PAH	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
Lipid Metabolism	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
LDL	associated_with	gene	0.60
Endothelial	regulates	cell_type	0.60
Macrophage	regulates	cell_type	0.60
Amyloid	activates	pathway	0.60
Cholesterol	regulates	pathway	0.60
Endocytosis	regulates	pathway	0.60
AGING	associated_with	gene	0.60
WNT	activates	gene	0.60
CANCER	activates	gene	0.60
Lipid Metabolism	activates	pathway	0.60
DENDRITE	activates	gene	0.60
Wnt	activates	pathway	0.60

Incoming (32)

Source	Relation	Type	Str
LRP8	associated_with	gene	0.60
PAH	activates	gene	0.60
WNT	expressed_in	gene	0.60
AND	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
RNA	associated_with	gene	0.60
LRP1B	associated_with	gene	0.60
PAH	associated_with	gene	0.60
LRP4	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
LRP6	associated_with	gene	0.60
DKK1	expressed_in	gene	0.60
LDL	associated_with	gene	0.60
STROKE	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
LRP1	associated_with	gene	0.60
LRP2	associated_with	gene	0.60
REELIN	associated_with	gene	0.60
APOE	activates	gene	0.60
APOE4	activates	gene	0.60
APP	activates	gene	0.60
SEMA3F	associated_with	gene	0.60
APOE3	activates	gene	0.60
DENDRITE	activates	gene	0.60
AGING	associated_with	gene	0.60
APOER2	associated_with	gene	0.60
WNT	associated_with	gene	0.60
AMYLOID	activates	gene	0.60
LRP1	expressed_in	gene	0.50
SEMA3F	expressed_in	gene	0.50
LDLR	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LRP5 in their description or question text

No additional research found