protein 649 words KG: NLRP2PROTEIN
Contents

NLRP2 Protein — NLR Family Pyrin Domain Containing 2

🔬 Protein Info
Gene SymbolNLRP2
Full NameNLR Family Pyrin Domain Containing 2
AliasesNLRP2PROTEIN
Chromosome19q13.42
Protein TypeReceptor
Functionis a member of the NOD-like receptor (NLR) family that plays critical roles in innate immunity and inflammasome formation.
Primary Expressionneurons, astrocytes, and microglia, where it participates in t
Molecular Weight114 kDa
Amino Acids975 aa
Exons10
PathwaysInflammasome, Innate Immunity, pyroptosis
Ensembl IDENSG00000163352
GeneCardsNLRP2
Human Protein AtlasNLRP2
N-terminal pyrin domain (PYD)Mediates protein-protein interactions
Associated DiseasesAutoimmune
InteractionsAND, CARD8, GAIN, NEURODEGENERATIVE DISEASES, NLRP1, NLRP10
KG Connections43 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (8)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (9)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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