gene 1,937 words KG: LRP2
Contents

LRP2 — Low Density Lipoprotein Receptor-Related Protein 2 (Megalin)

🧬 Gene Info
Gene SymbolLRP2
Full NameLow Density Lipoprotein Receptor-Related Protein 2 (Megalin)
AliasesPage for LRP2 Protein, Megalin
Chromosome2q31.1
Protein TypeProtein
Functionis a giant multiligand endocytic receptor of the LDL receptor family with high physiological relevance at epithelial interfaces, including the choroid plexus and brain barriers.
Molecular Weight600 kDa
Amino Acids630 aa
Exons79
PathwaysAngiogenesis, Apoptosis, Autophagy, Lipid Metabolism, Mtor
UniProt IDSearch UniProt
GeneCardsLRP2
Human Protein AtlasLRP2
Associated DiseasesAD, ADH, Aging, Als, AMI
Known Drugs/Compoundsrapamycin
InteractionsAMPK, AND, APOPTOSIS, ATG, ATP, CANCER
KG Connections263 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (23)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
APOE Isoform Conversion Therapy
Score: 0.72
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84

Related Analyses (9)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (15)

Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
ACTB Gene
gene · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: regulates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: regulates

Knowledge Graph (12 edges)

ACTB regulates LRP2
PPARA regulates LRP2
CAT regulates LRP2
SQSTM1 regulates LRP2
RPS6KB1 regulates LRP2
RAB7A regulates LRP2
SREBF1 regulates LRP2
EIF4EBP1 regulates LRP2
CTSD regulates LRP2
PPARGC1A regulates LRP2

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