protein

REELIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REELIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

340Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

3Experiments

0Debates

Summary

Comprehensive page on Reelin - structure, function, role in neuronal migration, synaptic plasticity, and Alzheimer's disease

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🔬 Protein Info

Gene Symbol	RELN
Aliases	Comprehensive page on Reelin
Chromosome	7q22.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	388 kDa
Amino Acids	460 aa
Pathways	Dendritic Spine
UniProt ID	P78536
NCBI Gene ID	5649
GeneCards	RELN
Human Protein Atlas	RELN
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE3, APOER2
KG Connections	318 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: REELIN — AlphaFold P78536 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Reelin Protein

protein · 876 words

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Pathway Diagram

graph TD
    REELIN["REELIN"] -->|"causes"| ALS["ALS"]
    REELIN["REELIN"] -.->|"inhibits"| ALS_1["ALS"]
    REELIN["REELIN"] -.->|"inhibits"| Alzheimer["Alzheimer"]
    REELIN["REELIN"] -->|"regulates"| ALS_2["ALS"]
    REELIN["REELIN"] -->|"associated"| Alzheimer_3["Alzheimer"]
    REELIN["REELIN"] -->|"associated"| Autism["Autism"]
    CDK5["CDK5"] -->|"causes"| REELIN["REELIN"]
    AXON["AXON"] -->|"causes"| REELIN["REELIN"]
    LIS1["LIS1"] -->|"causes"| REELIN["REELIN"]
    NEURON["NEURON"] -->|"causes"| REELIN["REELIN"]
    style REELIN fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (225)

Target	Relation	Type	Str
synaptogenesis	regulates	biological_process	0.90
Neuronal Migration	regulates	biological_process	0.90
Dendritic Spine Formation	regulates	biological_process	0.90
ApoER2	binds_to	protein	0.90
Synaptic Plasticity	regulates	biological_process	0.90
Dendritic Growth And Branching	regulates	biological_process	0.90
neuronal migration	regulates	process	0.90
NEURONAL MIGRATION	regulates	entity	0.90
synaptic plasticity	regulates	process	0.90
dendritic growth and branching	regulates	process	0.90
dendritic spine formation	regulates	process	0.90
synaptogenesis	regulates	process	0.90
Apoer2	binds	receptor	0.90
NF-κB	phosphorylates	protein	0.85
Nmda Receptor	activates	receptor	0.85
Heart Development	regulates	process	0.85
Injury Repair	regulates	process	0.85
AKT	phosphorylates	protein	0.85
platelet adhesion	promotes	process	0.85
PI3K	phosphorylates	protein	0.85
DEPRESSION	associated_with	disease	0.80
PI3K	activates	protein	0.80
AKT	activates	protein	0.80
mental retardation	implicated_in	disease	0.80
Alzheimer's disease	implicated_in	disease	0.80
Alzheimer's disease	associated_with	disease	0.80
lissencephaly	implicated_in	disease	0.80
AUTISM	implicated_in	disease	0.80
schizophrenia	implicated_in	disease	0.80
bipolar disorder	implicated_in	disease	0.80
Injury Repair	involved_in	process	0.75
Heart Development	involved_in	process	0.75
Alzheimer	therapeutic_target	disease	0.65
Addiction	therapeutic_target	disease	0.65
Depression	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Schizophrenia	associated_with	disease	0.65
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	protects_against	disease	0.65
Depression	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Autism	associated_with	disease	0.65
ALS	regulates	disease	0.65
Epilepsy	associated_with	disease	0.65
ALS	causes	disease	0.65
ALS	inhibits	disease	0.65

Incoming (115)

Source	Relation	Type	Str
DAB1	interacts_with	entity	0.85
VE-cadherin	regulates	protein	0.80
APP	associated_with	gene	0.75
ApoE	interacts_with	gene	0.70
NEURODEGENERATION	activates	gene	0.60
FGF	activates	gene	0.60
BRAIN INJURY	activates	gene	0.60
AXON	activates	gene	0.60
NEURON	activates	gene	0.60
EPILEPSY	mediates	entity	0.60
STROKE	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AUTISM	mediates	entity	0.60
DEPRESSION	mediates	entity	0.60
SYNAPSE	activates	gene	0.60
NEURON	therapeutic_target	gene	0.60
APOER2	protects_against	gene	0.60
STROKE	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
ARF6	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
DCX	causes	gene	0.60
PAFAH1B1	causes	gene	0.60
CDK5	causes	gene	0.60
LIS1	causes	gene	0.60
CD2AP	protects_against	entity	0.60
APOE	therapeutic_target	entity	0.60
LISSENCEPHALY	associated_with	entity	0.60
LISSENCEPHALY	mediates	entity	0.60
APOE	protects_against	gene	0.60
APP	regulates	gene	0.60
LDL	associated_with	gene	0.60
AND	associated_with	gene	0.60
DYNEIN	causes	gene	0.60
DAB1	causes	gene	0.60
REST	activates	gene	0.60
CD2AP	activates	gene	0.60
JUN	protects_against	gene	0.60
APOE	associated_with	gene	0.60
RELN	protects_against	gene	0.60
FYN	associated_with	gene	0.60
JUN	regulates	gene	0.60
SRC	associated_with	gene	0.60
DAB1	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
LRP4	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Reelin-Mediated Cytoskeletal Stabilization Protocol	0.689	neurodegeneration	Selective vulnerability of entorhinal co
H3: Reelin Signaling Deficiency Uncouples Layer II Neurons f	0.560	neurodegeneration	Entorhinal cortex layer II vulnerability

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
REL transcription factor mediates VLC ceramide-driven inflammation	exploratory	inflammation	0.750	0.00	innate immune cells	proposed	N/A
Levodopa Response Determinants in PSP — Biomarker-Guided Prediction St	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Neural Stem Cell Therapy for Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction. [PMID:39892386]	Vandal M, Institoris A, Reveret L, Korin	Neuron	2025	1
Protective genetic variants against Alzheimer's disease. [PMID:40409316]	Marino C, Malotaux V, Giudicessi A, Agui	Lancet Neurol	2025	1
Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional [PMID:39232006]	Serafin DS, Harris NR, Bálint L, Douglas	Nat Commun	2024	1
Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Devel [PMID:32604886]	Jossin Y	Biomolecules	2020	1
Neuronal migration. [PMID:11429281]	Lambert de Rouvroit C, Goffinet AM	Mech Dev	2001	1
Modulation of apolipoprotein E receptor-2 by ApoE4, amyloid β-peptide, reelin, a [PMID:41858499]	["Barger S", "Moerman-Herzog A"]	Frontiers in molecular neurosc	2026	0
The Potential Molecular Mechanisms and Key Genes of Early Deterioration of Paren [PMID:41863408]	["Cen G", "Li J", "Wang J", "Chen Y", "L	Current neurovascular research	2026	0
RELN biallelic variant as a candidate risk factor in a consanguineous Pakistani [PMID:41785923]	["Hashmi A", "Harripaul R", "Muhammad T"	Journal of affective disorders	2026	0
Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052]	Burdman Gabriel; Akkaoui Juliet; Colon N	Neurology international	2026	0
Temporal and Spatial Gene Expression Dynamics in Neonatal HI Hippocampus with Fo [PMID:41677619]	["Smith M", "Natarajan E", "Lizama-Valen	Cells	2026	0
Migration of dI5 Reelin-Lmx1b-Zfhx3 and Disabled-1-Lmx1b-Zfhx3 neurons contribut [PMID:41890024]	["Yvone G", "Chavez-Martinez C", "Mekonn	bioRxiv : the preprint server	2026	0
Whisking Behaviour Reveals Stronger Evidence of Habituation in Homozygous Reeler [PMID:41844513]	["Simanaviciute U", "Cetin A", "Guy J",	Genes, brain, and behavior	2026	0
Reln haploinsufficiency enhances fentanyl-induced locomotion and striatal activi [PMID:41890027]	["Litif C", "Libster A", "Desfor S", "Hu	bioRxiv : the preprint server	2026	0
Immunoglobulin allotypes and [PMID:41848375]	["Pandey J", "Namboodiri A", "Nietert P"	Journal of Alzheimer's disease	2026	0
Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052]	["Burdman G", "Akkaoui J", "Colon N", "P	Neurology international	2026	0
Genetic or therapeutic disruption of the Reelin/Apoer2 signaling pathway improve [PMID:40073057]	["Calvier L", "Wasser C", "Solow E", "Wu	Proceedings of the National Ac	2025	0
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheime [PMID:41035073]	Castanho I, Naderi Yeganeh P, Boix CA, M	Molecular neurodegeneration	2025	0
Glutamatergic argonaute2 promotes the formation of the neurovascular unit in mic [PMID:39999211]	Sona C, Yeh YT, Li Y, Liu X, Ghosh A, Hi	Science signaling	2025	0
APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodege [PMID:40307424]	["Vanherle S", "Janssen A", "Guti\u00e9r	Molecular psychiatry	2025	0
Protective Genes Against Alzheimer's Disease: Case Review and Therapeutic Implic [PMID:40321438]	Hossain N, Jeong Y	Dementia and neurocognitive di	2025	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning REELIN in their description or question text

No additional research found