gene

NEIL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEIL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

32Outgoing

6Incoming

0Experiments

0Debates

Summary

NEIL1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, implicated in. Associated with Als, Cancer, Carcinoma. Connected to 30 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NEIL1
Full Name	Nei Endonuclease VIII-Like 1
Chromosome	15q24.2
Function	The NEIL1 gene encodes a 406-amino acid DNA glycosylase that initiates base excision repair by recognizing and removing damaged bases:
Amino Acids	406 aa
UniProt ID	Q9Y3X0
NCBI Gene ID	57478
Ensembl ID	ENSG00000140323
OMIM	608747
GeneCards	NEIL1
Human Protein Atlas	NEIL1
Associated Diseases	neurodegeneration
Interactions	ABCB1, APOPTOSIS, ATM, BRAF, CANCER, COMPLEMENT
KG Connections	38 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NEIL1 — AlphaFold Q9Y3X0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NEIL1 — Nei Endonuclease VIII-Like 1

gene · 861 words

→

NEIL1 Protein — Nei Endonuclease VIII-Like 1

protein · 1179 words

→

Pathway Diagram

graph TD
    NEIL1["NEIL1"]
    Senescence{"Senescence"}
    NEIL1 -->|"interacts with"| Senescence
    Ms{"Ms"}
    NEIL1 -->|"interacts with"| Ms
    Tumor{"Tumor"}
    NEIL1 -->|"activates"| Tumor
    Als{"Als"}
    NEIL1 -->|"activates"| Als
    Cancer{"Cancer"}
    NEIL1 -->|"activates"| Cancer
    NEIL1 -->|"activates"| Ms
    Carcinoma{"Carcinoma"}
    NEIL1 -->|"activates"| Carcinoma
    COMPLEMENT["COMPLEMENT"]
    NEIL1 -->|"interacts with"| COMPLEMENT
    POLD1["POLD1"]
    NEIL1 -->|"interacts with"| POLD1
    P53["P53"]
    NEIL1 -->|"interacts with"| P53
    POT1["POT1"]
    NEIL1 -->|"interacts with"| POT1
    MRE11["MRE11"]
    NEIL1 -->|"interacts with"| MRE11
    TREX1["TREX1"]
    TREX1 -->|"interacts with"| NEIL1
    VCP["VCP"]
    VCP -->|"interacts with"| NEIL1
    ERK["ERK"]
    ERK -->|"activates"| NEIL1
    style NEIL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Carcinoma	activates	disease	0.65
Senescence	interacts_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Stem Cell	regulates	cell_type	0.60
P53	interacts_with	gene	0.60
Complement	interacts_with	pathway	0.60
CANCER	activates	gene	0.60
DNA	activates	gene	0.60
Apoptosis	inhibits	pathway	0.60
COMPLEMENT	interacts_with	gene	0.60
POLD1	interacts_with	gene	0.60
POT1	interacts_with	gene	0.60
MRE11	interacts_with	gene	0.60
MUTYH	interacts_with	gene	0.60
SAMHD1	interacts_with	gene	0.60
NBS1	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
WRN	interacts_with	gene	0.60
MDM2	interacts_with	gene	0.60
CTC1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
NEIL3	activates	gene	0.60
BRAF	activates	gene	0.60
NEIL2	activates	gene	0.60
ABCB1	activates	gene	0.60
neurodegeneration	associated_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60

Incoming (6)

Source	Relation	Type	Str
ERK	activates	gene	0.60
TREX1	interacts_with	gene	0.60
VCP	interacts_with	gene	0.60
DNA	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
RAD18	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEIL1 in their description or question text

No additional research found