gene

TREX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections

0Hypotheses

0Analyses

50Outgoing

22Incoming

0Experiments

0Debates

Summary

TREX1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, therapeutic target. Associated with Aging, Als, Cancer. Connected to 53 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TREX1
Full Name	Three Prime Repair Exonuclease 1
Chromosome	3p21.31
Function	is a gene located on chromosome 3p21.
Primary Expression	Ubiquitously expressed; high expression in brain, liver, spleen
Molecular Weight	33.9 kDa
Amino Acids	314 aa
Exons	3
Pathways	Nf-Κb
UniProt ID	Q9NSW9
NCBI Gene ID	9349
Ensembl ID	ENSG00000213465
OMIM	607400
GeneCards	TREX1
Human Protein Atlas	TREX1
Associated Diseases	Inflammation
Interactions	AGING, AND, ARID1A, ATM, CANCER, CD8
KG Connections	82 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TREX1 — AlphaFold Q9NSW9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TREX1 — Three Prime Repair Exonuclease 1

gene · 1008 words

→

TREX1 Protein

protein · 633 words

→

Pathway Diagram

graph TD
    TREX1["TREX1"]
    Als{"Als"}
    TREX1 -->|"regulates"| Als
    Ms{"Ms"}
    TREX1 -->|"regulates"| Ms
    TREX1 -->|"activates"| Ms
    Cancer{"Cancer"}
    TREX1 -->|"activates"| Cancer
    Senescence{"Senescence"}
    TREX1 -->|"interacts with"| Senescence
    TREX1 -->|"interacts with"| Ms
    IKBKG["IKBKG"]
    TREX1 -->|"regulates"| IKBKG
    PSMB8["PSMB8"]
    TREX1 -->|"associated with"| PSMB8
    Nf__b(["Nf-Kappab"])
    TREX1 -->|"regulates"| Nf__b
    CD8["CD8"]
    TREX1 -->|"activates"| CD8
    CANCER["CANCER"]
    TREX1 -->|"activates"| CANCER
    STING["STING"]
    TREX1 -->|"activates"| STING
    SAMHD1["SAMHD1"]
    SAMHD1 -->|"associated with"| TREX1
    style TREX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (60)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:TREX1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
STING activation	inhibits	process	0.90
STING	activates	gene	0.80
Cancer	activates	disease	0.75
CD8	activates	gene	0.70
DNA	activates	gene	0.70
CGAS	activates	gene	0.70
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Ms	activates	disease	0.65
Senescence	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Inflammation	treats	disease	0.65
Aging	therapeutic_target	disease	0.65
Senescence	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Als	inhibits	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Aging	activates	disease	0.65
Senescence	activates	disease	0.65
Immune Checkpoint	activates	pathway	0.60
Cgas-Sting	therapeutic_target	pathway	0.60
AND	therapeutic_target	gene	0.60
INFLAMMATION	associated_with	gene	0.60
T Cell	therapeutic_target	cell_type	0.60
CGAS-STING	activates	gene	0.60
AND	activates	gene	0.60
Nf-Κb	regulates	pathway	0.60
Rb	therapeutic_target	protein	0.60
UBIQUITIN	activates	gene	0.60
RNASEH2B	activates	gene	0.60
AGING	therapeutic_target	gene	0.60
Complement	interacts_with	pathway	0.60
IKBKG	regulates	gene	0.60
PSMB8	associated_with	gene	0.60
P53	interacts_with	gene	0.60
COMPLEMENT	interacts_with	gene	0.60
CANCER	activates	gene	0.60
VCP	interacts_with	gene	0.60
NEIL1	interacts_with	gene	0.60
POLD1	interacts_with	gene	0.60
POT1	interacts_with	gene	0.60
MRE11	interacts_with	gene	0.60
MUTYH	interacts_with	gene	0.60
SAMHD1	interacts_with	gene	0.60
NBS1	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60

Incoming (22)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:TREX1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
CGAS	therapeutic_target	gene	0.60
SAMHD1	associated_with	gene	0.60
CGAS	activates	gene	0.60
PSMB8	associated_with	gene	0.60
DSDNA	activates	gene	0.60
P53	activates	gene	0.60
AGING	activates	gene	0.60
ARID1A	activates	gene	0.60
RNASEH2B	activates	gene	0.60
CD8	activates	gene	0.60
STING	therapeutic_target	gene	0.60
STING	activates	gene	0.60
INFLAMMATION	treats	gene	0.60
AND	activates	gene	0.60
CGAS-STING	therapeutic_target	gene	0.60
TP53	inhibits	gene	0.60
TRIM24	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AND	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TREX1 in their description or question text

No additional research found