gene

SCN5A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCN5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

158Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SCN5A is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 102 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SCN5A
Chromosome	3p21
Protein Type	Gene
Function	encodes a large transmembrane protein of 2016 amino acids forming the alpha subunit of the cardiac sodium channel.
Amino Acids	2016 aa
Exons	28
GeneCards	SCN5A
Human Protein Atlas	SCN5A
Four homologous domains (I-IV)	Each containing six transmembrane segments (S1-S6)
Voltage sensor domain (VSD)	Segments S1-S4 respond to membrane depolarization
Pore domain	Segments S5-S6 form the ion selectivity filter
N-terminal domain	Contains inactivation gate and interaction sites
C-terminal domain	Modulates channel gating and protein interactions
Canonical isoform	Full-length Nav1.5 (2016 aa)
Alternative splicing	Produces functionally distinct isoforms
Associated Diseases	Aging, Als, Alzheimer, Autism, Cancer, Carcinoma
KG Connections	158 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SCN5A Gene

gene · 1009 words

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Pathway Diagram

graph TD
    SCN5A["SCN5A"] -->|"associated"| Cancer["Cancer"]
    SCN5A["SCN5A"] -->|"therapeutic target"| Als["Als"]
    SCN5A["SCN5A"] -->|"therapeutic target"| Cardiac["Cardiac"]
    SCN5A["SCN5A"] -->|"therapeutic target"| Ms["Ms"]
    SCN5A["SCN5A"] -->|"associated"| TRPM7["TRPM7"]
    SCN5A["SCN5A"] -->|"associated"| SCN1A["SCN1A"]
    PIEZO1["PIEZO1"] -->|"associated"| SCN5A["SCN5A"]
    KCNK2["KCNK2"] -->|"associated"| SCN5A["SCN5A"]
    CACNA1B["CACNA1B"] -->|"associated"| SCN5A["SCN5A"]
    CACNA1C["CACNA1C"] -->|"associated"| SCN5A["SCN5A"]
    style SCN5A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (87)

Target	Relation	Type	Str
Ovarian Cancer	associated_with	disease	0.80
Ovarian Cancer	biomarker_for	disease	0.80
Aging	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Als	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiac	therapeutic_target	disease	0.65
SCNN1A	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
KCNMA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
PIEZO1	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
IL1B	therapeutic_target	gene	0.60
KCNQ1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
CALM1	therapeutic_target	gene	0.60
LMNA	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
DRD2	therapeutic_target	gene	0.60
PPARG	therapeutic_target	gene	0.60
IDH2	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
ACHE	therapeutic_target	gene	0.60
CIRCADIAN RHYTHM	therapeutic_target	gene	0.60
Calcium Signaling	therapeutic_target	pathway	0.60
Complement	therapeutic_target	pathway	0.60
Circadian Rhythm	therapeutic_target	pathway	0.60
TCR	associated_with	gene	0.60
GENES	causes	gene	0.60
KCNN4	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
SYNAPSE	therapeutic_target	gene	0.60
Camp Signaling	therapeutic_target	pathway	0.60

Incoming (71)

Source	Relation	Type	Str
PIEZO1	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
HIPPO	associated_with	gene	0.60
AXON	associated_with	gene	0.60
AND	therapeutic_target	gene	0.60
CIRCADIAN RHYTHM	therapeutic_target	gene	0.60
ACHE	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
AND	causes	gene	0.60
WNT	associated_with	gene	0.60
RNA	associated_with	gene	0.60
KCNK2	causes	gene	0.60
TRPV4	causes	gene	0.60
CACNA1B	causes	gene	0.60
CACNA1C	causes	gene	0.60
TRPM7	causes	gene	0.60
SCNN1A	causes	gene	0.60
TRPV1	causes	gene	0.60
EPAS1	associated_with	gene	0.60
MYC	associated_with	gene	0.60
CALM1	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
KCNQ1	therapeutic_target	gene	0.60
DRD2	therapeutic_target	gene	0.60
IDH2	therapeutic_target	gene	0.60
KCNMA1	associated_with	entity	0.60
KCNN4	associated_with	entity	0.60
PIEZO2	associated_with	entity	0.60
SCN1A	associated_with	entity	0.60
KCNH2	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
KCNMA1	causes	gene	0.60
KCNQ1	causes	gene	0.60
PIEZO1	causes	gene	0.60
CFTR	causes	gene	0.60
SCN1A	causes	gene	0.60
TRPA1	causes	gene	0.60
KCNN4	causes	gene	0.60
PIEZO2	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCN5A in their description or question text

No additional research found