Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about POLD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
POLD1 - DNA Polymerase Delta 1 - Catalytic subunit of DNA polymerase delta essential for DNA replication and repair
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| Gene Symbol | POLD1 |
| Chromosome | 19q13.3 |
| Protein Family | DNA polymerase delta family |
| Function | The enzyme exhibits lower processivity compared to Pol ε (the leading strand polymerase) but achieves high fidelity through its intrinsic 3'→5' exonuclease proofreading activity[@burgers2019]. |
| Subcellular Localization | Nucleus |
| Molecular Weight | 124 kDa |
| UniProt ID | [P28340](https://www.uniprot.org/uniprot/P28340) |
| GeneCards | POLD1 |
| Human Protein Atlas | POLD1 |
| POLD1 (p125) | Catalytic subunit with polymerase and proofreading activities |
| POLD2 (p50) | Regulatory subunit, essential for complex stability |
| POLD3 (p66) | Accessory subunit, involved in subcellular localization |
| Associated Diseases | neurodegeneration |
| Interactions | ATM, MRE11, MUTYH, NBS1, NEIL1, P53 |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
POLD1["POLD1"]
Senescence{"Senescence"}
POLD1 -->|"interacts with"| Senescence
Ms{"Ms"}
POLD1 -->|"interacts with"| Ms
P53["P53"]
POLD1 -->|"interacts with"| P53
POT1["POT1"]
POLD1 -->|"interacts with"| POT1
MRE11["MRE11"]
POLD1 -->|"interacts with"| MRE11
MUTYH["MUTYH"]
POLD1 -->|"interacts with"| MUTYH
SAMHD1["SAMHD1"]
POLD1 -->|"expressed in"| SAMHD1
NBS1["NBS1"]
POLD1 -->|"interacts with"| NBS1
LMNA["LMNA"]
POLD1 -->|"expressed in"| LMNA
WRN["WRN"]
POLD1 -->|"interacts with"| WRN
MDM2["MDM2"]
POLD1 -->|"expressed in"| MDM2
CTC1["CTC1"]
POLD1 -->|"expressed in"| CTC1
TREX1["TREX1"]
TREX1 -->|"interacts with"| POLD1
VCP["VCP"]
VCP -->|"interacts with"| POLD1
NEIL1["NEIL1"]
NEIL1 -->|"interacts with"| POLD1
COMPLEMENT["COMPLEMENT"]
COMPLEMENT -->|"expressed in"| POLD1
style POLD1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | interacts_with | disease | 0.65 |
| Senescence | interacts_with | disease | 0.65 |
| MUTYH | interacts_with | gene | 0.60 |
| SAMHD1 | expressed_in | gene | 0.60 |
| NBS1 | interacts_with | gene | 0.60 |
| LMNA | expressed_in | gene | 0.60 |
| WRN | interacts_with | gene | 0.60 |
| MDM2 | expressed_in | gene | 0.60 |
| CTC1 | expressed_in | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| P53 | interacts_with | gene | 0.60 |
| POT1 | interacts_with | gene | 0.60 |
| Complement | expressed_in | pathway | 0.60 |
| MRE11 | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TREX1 | interacts_with | gene | 0.60 |
| VCP | interacts_with | gene | 0.60 |
| NEIL1 | interacts_with | gene | 0.60 |
| COMPLEMENT | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning POLD1 in their description or question text
No additional research found