gene

PDGFRB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDGFRB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

578Connections

3Hypotheses

3Analyses

50Outgoing

50Incoming

4Experiments

3Debates

Summary

PDGFRB is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, biomarker for. Associated with ALS, Aging, Als. Connected to 299 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PDGFRB
Full Name	Platelet Derived Growth Factor Receptor Beta
Chromosome	5q32
Protein Type	Kinase
Target Class	Kinase
Function	PDGFRB encodes the beta chain of the platelet-derived growth factor receptor, a receptor tyrosine kinase that binds PDGF-BB and PDGF-AB.
Mechanism of Action	Small molecule inhibitor of receptor tyrosine kinase activity
Druggability	Medium (0.50)
Clinical Stage	Approved
Pathways	PI3K, MAPK
UniProt ID	E5RII0
Ensembl ID	ENSG00000113721
OMIM	173410
GeneCards	PDGFRB
Human Protein Atlas	PDGFRB
Associated Diseases	Aging, Als, Alzheimers_disease, Basal Ganglia Calcifications, Cardiac
Known Drugs/Compounds	dasatinib, tyrosine_kinase_inhibitor
Interactions	ABCB1, ABL1, ABL2, AKT, AND, ANG
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Pericyte Contractility Reset via Selective PDGFR-β Pericyte-First Sequential Biomarker Cascade — Solu Vascular mural cell degeneration precedes and exac
KG Connections	578 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PDGFRB — AlphaFold E5RII0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PDGFRB — Platelet Derived Growth Factor Receptor Beta

gene · 1030 words

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Pathway Diagram

graph TD
    PDGFRB["PDGFRB"] -->|"associated"| neurodegeneration["neurodegeneration"]
    PDGFRB["PDGFRB"] -->|"interacts"| ANGPT1["ANGPT1"]
    PDGFRB["PDGFRB"] -->|"co discussed"| TGFB1["TGFB1"]
    ANGPT1_1["ANGPT1"] -->|"interacts"| PDGFRB["PDGFRB"]
    AQP1["AQP1"] -->|"co discussed"| PDGFRB["PDGFRB"]
    KCNK2["KCNK2"] -->|"co discussed"| PDGFRB["PDGFRB"]
    GJA1["GJA1"] -->|"co discussed"| PDGFRB["PDGFRB"]
    style PDGFRB fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (341)

Target	Relation	Type	Str
Primary Familial Brain Calcification	causes	disease	0.95
Primary Familial Brain Calcification	associated_with	disease	0.95
Basal Ganglia Calcifications	causes	disease	0.93
Fahr's Disease	risk_factor_for	disease	0.90
Cerebrovascular Integrity	biomarker_for	process	0.85
neurovascular unit	modulates	cell_type	0.80
pericyte_function	maintains	pathway	0.80
hepatic_stellate_cells	activates	cell_type	0.72
liver_fibrosis	activates	disease	0.72
myofibroblasts	expressed_in	cell_type	0.72
Ph_like_ALL	associated_with	disease	0.72
oxidative stress response	participates_in	pathway	0.70
Inflammation	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	regulates	disease	0.65
Leukemia	activates	disease	0.65
Ms	regulates	disease	0.65
Ms	interacts_with	disease	0.65
Cardiac	associated_with	disease	0.65
Fibrosis	activates	disease	0.65
Ms	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Senescence	therapeutic_target	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Cardiomyopathy	associated_with	disease	0.65
Aging	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Senescence	activates	disease	0.65
Tumor	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Cardiovascular	activates	disease	0.65
Inflammation	activates	disease	0.65
Arthritis	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	biomarker_for	disease	0.65
Als	activates	disease	0.65
ALS	regulates	disease	0.65

Incoming (237)

Source	Relation	Type	Str
h-73e4340b	targets	hypothesis	0.90
h-35f04e1b	targets	hypothesis	0.90
h_seaad_005	targets_gene	hypothesis	0.90
STING	upregulates	protein	0.85
PDGF_BB	activates	protein	0.72
PDGFD	interacts_with	protein	0.72
tyrosine_kinase_inhibitor	inhibits	drug	0.72
PDGF	activates	protein	0.72
dasatinib	inhibits	drug	0.72
CRLF2	activates	gene	0.70
MFSD2A	inhibits	gene	0.65
CSF1R	activates	gene	0.60
MYC	inhibits	gene	0.60
SRC	inhibits	gene	0.60
TAU	associated_with	gene	0.60
APOE Ε4	biomarker_for	gene	0.60
INSR	activates	gene	0.60
VEGFB	activates	gene	0.60
STING	activates	gene	0.60
PDGFB	associated_with	gene	0.60
AND	interacts_with	gene	0.60
FLT3	contributes_to	gene	0.60
CRLF2	inhibits	gene	0.60
JAK	inhibits	gene	0.60
APOD	activates	gene	0.60
GENES	inhibits	gene	0.60
COL1A1	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
THBS2	regulates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
CMPK2	associated_with	gene	0.60
AND	regulates	gene	0.60
PDGF	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
AND	inhibits	gene	0.60
PDGF	inhibits	gene	0.60
NINJ2	activates	gene	0.60
PDGF	interacts_with	gene	0.60
SQSTM1	biomarker_for	gene	0.60
NEFL	biomarker_for	gene	0.60
CHI3L1	associated_with	gene	0.60
BDNF	biomarker_for	gene	0.60
ANGPT1	associated_with	gene	0.60
CHI3L1	interacts_with	gene	0.60
CHIT1	interacts_with	gene	0.60
NPTX1	interacts_with	gene	0.60
PDGFRA	implicated_in	gene	0.60
EPOR	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Pericyte Contractility Reset via Selective PDGFR-β Agonism	0.684	neurodegeneration	Perivascular spaces and glymphatic clear
Pericyte-First Sequential Biomarker Cascade — Soluble PDGFR-	0.662	-	Blood-brain barrier permeability changes
Vascular mural cell degeneration precedes and exacerbates pa	0.637	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Irisin effects on angiogenesis in human endothelial cells	exploratory	bone fracture	0.900	0.00	human umbilical vein endotheli	proposed	N/A
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,280,000
Vascular Contributions to Alzheimer Disease and Mixed Pathology	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726]	Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu	Cell Stem Cell	2025	1
Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043]	Kempuraj D, Dourvetakis KD, Cohen J, Val	Front Cell Neurosci	2024	1
The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066]	Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T	Int J Mol Sci	2023	1
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044]	Calvier L, Herz J, Hansmann G	JACC Basic Transl Sci	2022	1
Decoding myofibroblast origins in human kidney fibrosis. [PMID:33176333]	Kuppe C, Ibrahim MM, Kranz J, Zhang X, Z	Nature	2021	1
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. [PMID:32376954]	Montagne A, Nation DA, Sagare AP, Barisa	Nature	2020	1
Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990]	Keller A	Annual review of physiology	2026	0
A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increas [PMID:41890033]	Levey J, Howe M, Douglas K, Odame E, Raj	bioRxiv : the preprint server	2026	0
Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in h [PMID:40902811]	Wang Y, Zhang Z, Cao L, Huang S, Huang X	J Ethnopharmacol	2026	0
Based on network pharmacology and experiments to investigate the inhibitory effe [PMID:41308710]	Yang X, Xiao JH, Li X, Liu RM, Yuan Q	J Ethnopharmacol	2026	0
Novel insights into meningioma brain invasion with spatial transcriptomic profil [PMID:41486296]	Maier AD, Laurentiussen CO, Michaelsen S	Acta Neuropathol Commun	2026	0
Brain vascular stability relies on PAK2-cilia-PDGF-BB-HSPGs on basolateral side [PMID:41490797]	Prabhudesai S, Thirugnanam K, Song X, Ya	Life Sci Alliance	2026	0
Plasma platelet-derived growth factor receptor-β decrease correlates with blood- [PMID:41530860]	Li J, Li A, Ye C, Zhang L, Jiang M et al	Mol Neurodegener	2026	0
FOXF2 regulates pericyte-endothelial signaling required for vascular homeostasis [PMID:41680210]	Sun F, Zhao Y, Do J, Cheng P, Li E et al	Nat Commun	2026	0
Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and T [PMID:41884335]	Fu X, Fan J, Chen H, Zheng Y, Liu Y, Zha	Research (Washington, D.C.)	2026	0
Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129]	Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu	Clinical & experimental ophtha	2026	0
Central nervous system pericytes express soluble ST2 in inflammation and injury. [PMID:41857656]	Jansson D, Highet B, Li S, Stevenson TJ,	Molecular brain	2026	0
Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235]	Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn	Pathology international	2026	0
The role of endothelial cell-pericyte interactions in vascularization and diseas [PMID:38246244]	Li G, Gao J, Ding P, Gao Y	Journal of advanced research	2025	0
Pericytes in Brain Homeostasis: Developmental Roles and Adult Functions. [PMID:41351407]	Drozd U, Vechkapova S, Lanshakov D	Frontiers in bioscience (Landm	2025	0

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning PDGFRB in their description or question text

No additional research found