Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TPM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TPM1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, regulates. Associated with Als, Cardiac, Fibrosis. Connected to 23 entities in the SciDEX knowledge graph.
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| Gene Symbol | TPM1 |
| Full Name | Tropomyosin 1 |
| Chromosome | 15q22.1 |
| Function | Tropomyosins are key regulators of actin filament dynamics and function through several mechanisms |
| Primary Expression | neurons and has been implicated in neurodegenerative diseases, particularly [Amyotrophic Lateral Sclerosis (ALS](/diseases/amyotr |
| Pathways | Autophagy, Histone Modification |
| UniProt ID | P09493 |
| NCBI Gene ID | 7168 |
| Ensembl ID | ENSG00000140416 |
| OMIM | 191010 |
| GeneCards | TPM1 |
| Human Protein Atlas | TPM1 |
| Associated Diseases | neurodegeneration |
| Interactions | AND, APOPTOSIS, BCL-2, BNIP3, IDH3A, MITOPHAGY |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TPM1["TPM1"]
Fibrosis{"Fibrosis"}
TPM1 -->|"inhibits"| Fibrosis
Als{"Als"}
TPM1 -->|"inhibits"| Als
Cardiac{"Cardiac"}
TPM1 -->|"regulates"| Cardiac
Ischemia{"Ischemia"}
TPM1 -->|"regulates"| Ischemia
Heart_Failure{"Heart Failure"}
TPM1 -->|"therapeutic target"| Heart_Failure
Ms{"Ms"}
TPM1 -->|"therapeutic target"| Ms
APOPTOSIS["APOPTOSIS"]
TPM1 -->|"inhibits"| APOPTOSIS
AUTOPHAGY["AUTOPHAGY"]
TPM1 -->|"regulates"| AUTOPHAGY
BCL_2["BCL-2"]
TPM1 -->|"inhibits"| BCL_2
IDH3A["IDH3A"]
TPM1 -->|"inhibits"| IDH3A
Apoptosis(["Apoptosis"])
TPM1 -->|"inhibits"| Apoptosis
Autophagy(["Autophagy"])
TPM1 -->|"regulates"| Autophagy
BNIP3["BNIP3"]
BNIP3 -->|"inhibits"| TPM1
MITOPHAGY["MITOPHAGY"]
MITOPHAGY -->|"inhibits"| TPM1
PHGDH["PHGDH"]
PHGDH -->|"therapeutic target"| TPM1
LAMA2["LAMA2"]
LAMA2 -->|"therapeutic target"| TPM1
PLN["PLN"]
PLN -->|"therapeutic target"| TPM1
style TPM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | inhibits | disease | 0.65 |
| Cardiac | regulates | disease | 0.65 |
| Ischemia | regulates | disease | 0.65 |
| Fibrosis | inhibits | disease | 0.65 |
| Heart Failure | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Mitophagy | inhibits | pathway | 0.60 |
| GENE MUTATIONS | therapeutic_target | gene | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| BCL-2 | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Histone Modification | regulates | pathway | 0.60 |
| IDH3A | inhibits | gene | 0.60 |
| LMNA | therapeutic_target | gene | 0.60 |
| ATF4 | therapeutic_target | gene | 0.60 |
| BNIP3 | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TPM1 in their description or question text
No additional research found