gene

KCNQ1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNQ1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

151Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

KCNQ1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, causes. Associated with Als, Cancer, Cardiac. Connected to 98 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KCNQ1
Full Name	Potassium Voltage-Gated Channel Subfamily Q Member 1
Aliases	KV7.1
Chromosome	11p15.5.
Protein Type	Channel
Function	KCNQ1 channels perform essential functions in various tissues:
Molecular Weight	75 kDa
Amino Acids	676 aa
Exons	19
Pathways	Wnt/β-catenin signaling
UniProt ID	P51787
NCBI Gene ID	3785
Ensembl ID	ENSG00000143338
OMIM	607542
GeneCards	KCNQ1
Human Protein Atlas	KCNQ1
Associated Diseases	Cancer, Ovarian Cancer
Interactions	KCNE1, KCNE3
KG Connections	151 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNQ1 — AlphaFold P51787 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNQ1 (KV7.1)

gene · 935 words

→

KCNQ1 Protein (KV7.1)

protein · 879 words

→

Pathway Diagram

graph TD
    KCNQ1["KCNQ1"]
    KCNQ1 -->|"interacts"| KCNE1["KCNE1"]
    KCNQ1 -->|"regulates"| Wnt___catenin_signaling["Wnt/beta-catenin signaling"]
    KCNQ1 -->|"binds"| KCNE3["KCNE3"]
    KCNQ1 -->|"binds"| PIP2["PIP2"]
    KCNQ1 -->|"binds"| beta_tubulin["beta-tubulin"]
    KCNQ1 -->|"activates"| MET_receptor["MET receptor"]
    KCNQ1 -->|"downregulates"| DKK_1["DKK-1"]
    KCNQ1 -->|"downregulates"| Wif_1["Wif-1"]
    KCNQ1 -->|"downregulates"| NKD_1["NKD-1"]
    KCNQ1 -->|"upregulates"| Cdkn1c["Cdkn1c"]
    HRH2["HRH2"] -->|"upregulates"| KCNQ1
    KCNE3 -->|"modulates"| KCNQ1
    KCNH2["KCNH2"] -->|"target for"| KCNQ1
    IDH1["IDH1"] -->|"target for"| KCNQ1
    TP53["TP53"] -->|"target for"| KCNQ1
    SCN5A["SCN5A"] -->|"target for"| KCNQ1
    IL1B["IL1B"] -->|"target for"| KCNQ1
    KCNMA1["KCNMA1"] -->|"causes"| KCNQ1

Outgoing (91)

Target	Relation	Type	Str
KCNE1	interacts_with	gene	0.90
Wnt/β-catenin signaling	regulates	pathway	0.90
PIP2	binds	chemical	0.80
beta-tubulin	binds	protein	0.80
Ovarian Cancer	biomarker_for	disease	0.80
KCNE3	binds	gene	0.80
MET receptor	activates	receptor	0.80
DKK-1	downregulates	gene	0.80
Wif-1	downregulates	gene	0.80
NKD-1	downregulates	gene	0.80
Cdkn1c	upregulates	gene	0.80
Kcnq1ot1	regulates	gene	0.80
Ovarian Cancer	associated_with	disease	0.80
Insulin secretion	regulates	process	0.80
Pdx1	regulates	gene	0.70
Wnt/β-catenin signaling	interacts_with	pathway	0.70
Als	therapeutic_target	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Monocyte	associated_with	cell_type	0.60
Fibroblast	associated_with	cell_type	0.60
TNF	therapeutic_target	gene	0.60
CALM1	therapeutic_target	gene	0.60
LMNA	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
DRD2	therapeutic_target	gene	0.60
PPARG	therapeutic_target	gene	0.60
IDH2	therapeutic_target	gene	0.60
PIEZO1	causes	gene	0.60
CFTR	causes	gene	0.60
SCN1A	causes	gene	0.60
TRPA1	causes	gene	0.60
KCNN4	causes	gene	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
TRPV4	causes	gene	0.60
SCNN1A	causes	gene	0.60
TRPV1	causes	gene	0.60
KCNK2	causes	gene	0.60
CACNA1B	causes	gene	0.60
CACNA1C	causes	gene	0.60
TRPM7	causes	gene	0.60
TRPV4	associated_with	entity	0.60
Oxidative Phosphorylation	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
ACHE	therapeutic_target	gene	0.60
CIRCADIAN RHYTHM	therapeutic_target	gene	0.60
Complement	therapeutic_target	pathway	0.60
Macrophage	associated_with	cell_type	0.60

Incoming (60)

Source	Relation	Type	Str
KCNE3	modulates	gene	0.80
KCNE3	regulates	gene	0.80
KCNE3	activates	gene	0.80
TRPV1	causes	gene	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
CFTR	causes	gene	0.60
SCNN1A	causes	gene	0.60
SCN1A	causes	gene	0.60
CACNA1C	causes	gene	0.60
KCNN4	causes	gene	0.60
TRPV4	causes	gene	0.60
TRPM7	causes	gene	0.60
RNA	associated_with	gene	0.60
CACNA1B	causes	gene	0.60
TRPA1	causes	gene	0.60
TCR	associated_with	gene	0.60
AXON	associated_with	gene	0.60
CIRCADIAN RHYTHM	therapeutic_target	gene	0.60
ACHE	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
AND	causes	gene	0.60
KCNMA1	causes	gene	0.60
CALM1	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
CANCER	associated_with	gene	0.60
HIPPO	associated_with	gene	0.60
GENES	causes	gene	0.60
WNT	associated_with	gene	0.60
KCNH2	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
SCN5A	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
PIEZO1	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
KCNMA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
PIEZO1	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNQ1 in their description or question text

No additional research found