protein 1,305 words KG: LMNA
Contents

LMNA Protein

🔬 Protein Info
Gene SymbolLMNA
Chromosome1q22
Protein TypeProtein
Function### Nuclear Lamina Structure
Primary ExpressionUniversal (all cell types)
Molecular Weight72 kDa
Amino Acids33 aa
Exons12
Pathwayscalcium_homeostasis
UniProt IDP02545
NCBI Gene ID3999
Ensembl IDENSG00000160789
OMIM150330
GeneCardsLMNA
Human Protein AtlasLMNA
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
InteractionsA2M, ABCD3, ACETYL-COA, Actin, AGING, ALS
KG Connections817 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (33)

Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
APOE-Dependent Autophagy Restoration
Score: 0.88
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
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Related Analyses (10)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

See Also (7)

A2M Gene
gene · KG edge: interacts_with
ABCD3 Gene
gene · KG edge: activates
AMBRA1 Gene
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (12 edges)

LMNA causes DCM
LMNA encodes Lamin_AC
LMNA regulates calcium_homeostasis
NCSTN interacts_with LMNA
FAS interacts_with LMNA
TNF interacts_with LMNA
LMNA interacts_with APH1B
LMNA interacts_with APOE
LMNA interacts_with IL6
LMNA interacts_with SREBF1

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