gene

CALM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

125Connections

0Hypotheses

0Analyses

50Outgoing

42Incoming

0Experiments

0Debates

Summary

CALM1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, interacts with, associated with. Associated with Als, Autism, Carcinoma. Connected to 38 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CALM1
Full Name	Calmodulin 1
Chromosome	14q32.11
Protein Family	Calmodulin family
Function	Binds 4 Ca2+ ions upon calcium elevation
Primary Expression	all cell types - High in brain: Particularly in cortex, hippocampus, cerebellum - Isoform
Molecular Weight	16.7 kDa
Amino Acids	149 aa
Pathways	mTOR, mtor
UniProt ID	P62158
NCBI Gene ID	801
Ensembl ID	ENSG00000198668
GeneCards	CALM1
Human Protein Atlas	CALM1
Associated Diseases	Aging, Als, Alzheimer, Ms
Interactions	AKT1, ALZHEIMER, AND, ASPM, AURKB, CDC42
KG Connections	125 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CALM1 — AlphaFold P62158 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CALM1 — Calmodulin 1

gene · 690 words

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Pathway Diagram

graph TD
    CALM1["CALM1"]
    Ms{"Ms"}
    CALM1 -->|"interacts with"| Ms
    Carcinoma{"Carcinoma"}
    CALM1 -->|"interacts with"| Carcinoma
    CALM1 -->|"associated with"| Ms
    Autism{"Autism"}
    CALM1 -->|"expressed in"| Autism
    Als{"Als"}
    CALM1 -->|"therapeutic target"| Als
    Cardiac{"Cardiac"}
    CALM1 -->|"therapeutic target"| Cardiac
    CALM1 -->|"therapeutic target"| Ms
    HSP90AA1["HSP90AA1"]
    CALM1 -->|"interacts with"| HSP90AA1
    JUN["JUN"]
    CALM1 -->|"interacts with"| JUN
    Akt(["Akt"])
    CALM1 -->|"interacts with"| Akt
    ACTB["ACTB"]
    CALM1 -->|"associated with"| ACTB
    CALM1 -->|"associated with"| JUN
    TP53["TP53"]
    TP53 -->|"interacts with"| CALM1
    SOD1["SOD1"]
    SOD1 -->|"interacts with"| CALM1
    AKT1["AKT1"]
    AKT1 -->|"interacts with"| CALM1
    EGFR["EGFR"]
    EGFR -->|"interacts with"| CALM1
    MAPK1["MAPK1"]
    MAPK1 -->|"associated with"| CALM1
    RHOA["RHOA"]
    RHOA -->|"associated with"| CALM1
    EGFR -->|"associated with"| CALM1
    KCNH2["KCNH2"]
    KCNH2 -->|"therapeutic target"| CALM1
    IDH1["IDH1"]
    IDH1 -->|"therapeutic target"| CALM1
    TP53 -->|"therapeutic target"| CALM1
    SCN5A["SCN5A"]
    SCN5A -->|"therapeutic target"| CALM1
    IL1B["IL1B"]
    IL1B -->|"therapeutic target"| CALM1
    style CALM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (83)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.65
Autism	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Aging	associated_with	disease	0.65
Diabetes	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
JUN	associated_with	gene	0.60
LMNA	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
DRD2	therapeutic_target	gene	0.60
PPARG	therapeutic_target	gene	0.60
IDH2	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
KCNQ1	therapeutic_target	gene	0.60
KCNH2	therapeutic_target	gene	0.60
SCN5A	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
NEFH	associated_with	gene	0.60
KIF5B	interacts_with	gene	0.60
CDC42	associated_with	gene	0.60
PVALB	interacts_with	gene	0.60
SST	interacts_with	gene	0.60
GAP43	associated_with	gene	0.60
SLC6A1	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
TXN	interacts_with	gene	0.60
PIK3R1	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
KIF15	associated_with	gene	0.60
AURKB	interacts_with	gene	0.60
RANK	interacts_with	gene	0.60
Synaptic Vesicle	expressed_in	pathway	0.60
Synaptic Transmission	therapeutic_target	pathway	0.60
AND	interacts_with	gene	0.60
HUB GENES	associated_with	gene	0.60
HUB GENES	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
DIABETES MELLITUS	expressed_in	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GJA1	interacts_with	gene	0.60
LPL	interacts_with	gene	0.60

Incoming (42)

Source	Relation	Type	Str
PIK3R1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
MAPK1	associated_with	gene	0.60
RHOA	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
LPL	interacts_with	gene	0.60
APOE	associated_with	gene	0.60
TXN	interacts_with	gene	0.60
KCNH2	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
SCN5A	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
KCNQ1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
KIF15	associated_with	gene	0.60
NEFL	associated_with	gene	0.60
TPR	associated_with	gene	0.60
RANK	therapeutic_target	gene	0.60
CDC42	associated_with	gene	0.60
GAP43	associated_with	gene	0.60
GJA1	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
KIF5B	interacts_with	gene	0.60
SST	interacts_with	gene	0.60
AURKB	associated_with	gene	0.60
AURKB	interacts_with	gene	0.50
ASPM	interacts_with	protein	0.50
CDC42	interacts_with	gene	0.50
NEFH	associated_with	gene	0.50
PVALB	associated_with	gene	0.50
PVALB	interacts_with	gene	0.50
SLC6A1	interacts_with	gene	0.50
PLCG2	inhibits	gene	0.50
PIK3R1	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CALM1 in their description or question text

No additional research found