gene

MUTYH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MUTYH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

33Outgoing

15Incoming

0Experiments

0Debates

Summary

MUTYH is a gene implicated in neurodegeneration research. Key relationships include: interacts with, contributes to, regulates. Associated with Cancer, Heritable Cancer Predisposition, Ms. Connected to 31 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	MUTYH
Chromosome	1p34.2
Protein Type	Enzyme
Function	Without MUTYH, the mispaired adenine becomes fixed as a G:C to T:A mutation during replication.
Primary Expression	all tissues, with high expression in: - Brain: cerebral cortex, hippocampus, cerebellum -
Molecular Weight	52 kDa
Amino Acids	479 aa
Exons	16
Pathways	DNA Repair
GeneCards	MUTYH
Human Protein Atlas	MUTYH
Associated Diseases	Als, cancer, neurodegeneration
Interactions	ATM, COMPLEMENT, CTC1, DNA, LMNA, MDM2
KG Connections	48 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MUTYH Gene

gene · 1092 words

→

MUTYH Protein

protein · 1206 words

→

Pathway Diagram

graph TD
    MUTYH["MUTYH"]
    Cancer{"Cancer"}
    MUTYH -->|"contributes to"| Cancer
    Tumor{"Tumor"}
    MUTYH -->|"contributes to"| Tumor
    Senescence{"Senescence"}
    MUTYH -->|"interacts with"| Senescence
    Ms{"Ms"}
    MUTYH -->|"interacts with"| Ms
    DNA["DNA"]
    MUTYH -->|"contributes to"| DNA
    Dna_Repair(["Dna Repair"])
    MUTYH -->|"contributes to"| Dna_Repair
    SAMHD1["SAMHD1"]
    MUTYH -->|"interacts with"| SAMHD1
    NBS1["NBS1"]
    MUTYH -->|"interacts with"| NBS1
    LMNA["LMNA"]
    MUTYH -->|"interacts with"| LMNA
    WRN["WRN"]
    MUTYH -->|"interacts with"| WRN
    MDM2["MDM2"]
    MUTYH -->|"interacts with"| MDM2
    CTC1["CTC1"]
    MUTYH -->|"interacts with"| CTC1
    TREX1["TREX1"]
    TREX1 -->|"interacts with"| MUTYH
    VCP["VCP"]
    VCP -->|"interacts with"| MUTYH
    NEIL1["NEIL1"]
    NEIL1 -->|"interacts with"| MUTYH
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"interacts with"| MUTYH
    POLD1["POLD1"]
    POLD1 -->|"interacts with"| MUTYH
    P53["P53"]
    P53 -->|"interacts with"| MUTYH
    POT1["POT1"]
    POT1 -->|"interacts with"| MUTYH
    MRE11["MRE11"]
    MRE11 -->|"interacts with"| MUTYH
    DNA -->|"contributes to"| MUTYH
    CANCER["CANCER"]
    CANCER -->|"contributes to"| MUTYH
    AND["AND"]
    AND -->|"regulates"| MUTYH
    style MUTYH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (33)

Target	Relation	Type	Str
C>A Germline Mutations	regulates	phenotype	0.95
SBS18 Mutation Signature	associated_with	biomarker	0.92
Heritable Cancer Predisposition	risk_factor_for	disease	0.88
Senescence	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Tumor	contributes_to	disease	0.65
Cancer	associated_with	disease	0.65
neurodegeneration	associated_with	disease	0.60
OGG1	activates	gene	0.60
neurodegeneration	activates	disease	0.60
DNA	contributes_to	gene	0.60
ATM	interacts_with	gene	0.60
OGG1	associated_with	gene	0.60
neurodegeneration	regulates	disease	0.60
SAMHD1	interacts_with	gene	0.60
NBS1	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
WRN	interacts_with	gene	0.60
MDM2	interacts_with	gene	0.60
CTC1	interacts_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60
Dna Repair	associated_with	pathway	0.60
Complement	interacts_with	pathway	0.60
CANCER	contributes_to	gene	0.60
BMP	associated_with	gene	0.60
GENETIC MODIFIERS	regulates	gene	0.60
Insulin Signaling	associated_with	pathway	0.60
Epigenetic	associated_with	pathway	0.60
T Cell	associated_with	cell_type	0.60
Insulin	associated_with	protein	0.60
cancer	causes	disease	0.50
Dna Repair	causes	pathway	0.50

Incoming (15)

Source	Relation	Type	Str
GENETIC MODIFIERS	regulates	gene	0.60
DNA	associated_with	gene	0.60
CANCER	contributes_to	gene	0.60
AND	regulates	gene	0.60
PI3K	associated_with	gene	0.60
TREX1	interacts_with	gene	0.60
VCP	interacts_with	gene	0.60
NEIL1	interacts_with	gene	0.60
POLD1	interacts_with	gene	0.60
POT1	interacts_with	gene	0.60
MRE11	interacts_with	gene	0.60
DNA	inhibits	gene	0.60
COMPLEMENT	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
CANCER	causes	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MUTYH in their description or question text

No additional research found