gene

CHIT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHIT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

129Connections

1Hypotheses

1Analyses

50Outgoing

43Incoming

0Experiments

1Debates

Summary

CHIT1 encodes chitotriosidase, a chitinase enzyme expressed in activated microglia and implicated as a biomarker in Alzheimer's disease, Parkinson's disease, and Gaucher disease

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🧬 Gene Info

Gene Symbol	CHIT1
Full Name	Chitinase 1
Chromosome	1q32.1
Protein Type	Enzyme
Function	encodes a hydrolytic enzyme that degrades chitin, a polymer of N-acetylglucosamine found in fungal cell walls, insect exoskeletons, and some parasites.
Molecular Weight	50 kDa
Amino Acids	466 aa
Exons	12
Pathways	oxidative stress response
UniProt ID	Q01228
NCBI Gene ID	1118
Ensembl ID	ENSG00000133093
OMIM	607203
GeneCards	CHIT1
Human Protein Atlas	CHIT1
Associated Diseases	Inflammation, Neuroinflammation
Interactions	AND, AXL, CHI3L1, CXCL1, CXCL10, CXCL9
KG Connections	129 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CHIT1 — AlphaFold Q01228 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CHIT1 Gene (Chitinase 1)

gene · 1361 words

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Pathway Diagram

graph TD
    CHIT1["CHIT1"] -->|"therapeutic target"| Atherosclerosis["Atherosclerosis"]
    CHIT1["CHIT1"] -.->|"inhibits"| Als["Als"]
    CHIT1["CHIT1"] -->|"therapeutic target"| Cardiovascular["Cardiovascular"]
    CHIT1["CHIT1"] -->|"therapeutic target"| Inflammation["Inflammation"]
    CHIT1["CHIT1"] -->|"biomarker for"| Neurodegeneration["Neurodegeneration"]
    CHIT1["CHIT1"] -->|"biomarker for"| Als_1["Als"]
    CXCL1["CXCL1"] -->|"therapeutic target"| CHIT1["CHIT1"]
    CXCL10["CXCL10"] -->|"therapeutic target"| CHIT1["CHIT1"]
    IL9["IL9"] -->|"biomarker for"| CHIT1["CHIT1"]
    VEGFA["VEGFA"] -->|"associated"| CHIT1["CHIT1"]
    style CHIT1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (86)

Target	Relation	Type	Str
Tau Pathology	biomarker_for	process	0.85
oxidative stress response	participates_in	pathway	0.70
Atherosclerosis	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
ALS	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
ALS	biomarker_for	disease	0.65
Als	inhibits	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
APOE Ε4	biomarker_for	gene	0.60
TAU PATHOLOGY	biomarker_for	gene	0.60
Bdnf	biomarker_for	protein	0.60
AXL	inhibits	gene	0.60
MMP12	therapeutic_target	gene	0.60
CXCL1	therapeutic_target	gene	0.60
Innate Immunity	therapeutic_target	pathway	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
Cerebrovascular	associated_with	pathway	0.60
CHI3L1	associated_with	gene	0.60
IL-6	inhibits	gene	0.60
Innate Immunity	inhibits	pathway	0.60
NEUROINFLAMMATION	biomarker_for	entity	0.60
APOE	biomarker_for	gene	0.60
NEFL	biomarker_for	gene	0.60
Pdgf	associated_with	protein	0.60
Fgf	biomarker_for	protein	0.60
App	biomarker_for	protein	0.60
microglia	expressed_in	cell_type	0.60
MDH1	biomarker_for	gene	0.60
PDGFRB	associated_with	gene	0.60
SQSTM1	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
NPTX1	activates	gene	0.60
PDGFRB	activates	gene	0.60
neuroinflammation	activates	disease	0.60
CYTOKINES	biomarker_for	gene	0.60
CXCL10	therapeutic_target	gene	0.60
TAU	biomarker_for	entity	0.60
VEGFA	biomarker_for	entity	0.60
CXCL1	inhibits	gene	0.60
TAU	associated_with	gene	0.60
MMP12	inhibits	gene	0.60

Incoming (43)

Source	Relation	Type	Str
CXCL10	inhibits	gene	0.60
CHI3L1	biomarker_for	entity	0.60
AXL	downregulates	entity	0.60
AXL	associated_with	gene	0.60
CHI3L1	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
IL9	biomarker_for	gene	0.60
VEGFA	associated_with	gene	0.60
IL4	biomarker_for	gene	0.60
FGF2	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
NPTX1	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
TAU	associated_with	gene	0.60
MDH1	biomarker_for	gene	0.60
NEFL	biomarker_for	gene	0.60
MMP12	inhibits	gene	0.60
AMYLOID	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
TAU PATHOLOGY	biomarker_for	gene	0.60
INFLAMMATION	associated_with	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
IL-6	inhibits	gene	0.60
AND	inhibits	gene	0.60
CXCL1	therapeutic_target	gene	0.60
CXCL10	therapeutic_target	gene	0.60
AXL	inhibits	gene	0.60
APOE	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
CXCL1	inhibits	gene	0.60
CHI3L1	associated_with	gene	0.60
SQSTM1	biomarker_for	gene	0.60
CHI3L1	activates	gene	0.60
AND	associated_with	gene	0.60
CXCL9	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
MMP12	therapeutic_target	gene	0.60
Neuroinflammation	interacts_with	process	0.50
PDGFRB	interacts_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Disease-Elevated CHI3L1/CHIT1 Chitinases Are Biomarkers and	0.500	ALS	What are the mechanisms by which microgl

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which microglial senescence contributes to ALS pathol

neurodegeneration | 2026-04-26 | 4 hypotheses Top: 0.776

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms by which microglial senescence contributes to ALS pathol

active · Rounds: 6 · Score: 0.75 · 2026-04-26

Related Research

Hypotheses and analyses mentioning CHIT1 in their description or question text

No additional research found