gene

arrb1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about arrb1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

12Outgoing

7Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ARRB1
Full Name	Arrestin Beta 1
Aliases	β-arrestin 1
Chromosome	11q13.1
Function	ARRB1 recognizes these phosphorylated receptors through multiple phosphate sensors in its N-terminal domain.
Molecular Weight	46 kDa
Amino Acids	418 aa
Pathways	MAPK, PI3K
UniProt ID	[P49407](https://www.uniprot.org/uniprot/P49407)
Ensembl ID	ENSG00000141428
OMIM	107940
GeneCards	ARRB1
Human Protein Atlas	ARRB1
Associated Diseases	Cancer
Interactions	AUTOPHAGY, RAB27A, SAMD4
KG Connections	19 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ARRB1 — Arrestin Beta 1

gene · 1388 words

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Pathway Diagram

graph TD
    ARRB1["ARRB1"]
    ARRB1 -->|"inhibits"| autophagy["autophagy"]
    ARRB1 -->|"regulates"| MASP1["MASP1"]
    ARRB1 -->|"activates"| RAB27A["RAB27A"]
    ARRB1 -->|"interacts"| SAMD4["SAMD4"]
    ARRB1 -->|"activates"| Carcinoma["Carcinoma"]
    ARRB1 -->|"activates"| Hepatitis["Hepatitis"]
    ARRB1 -->|"activates"| Autophagy["Autophagy"]
    ARRB1 -->|"implicated in"| neurodegeneration["neurodegeneration"]
    IL_4["IL-4"] -->|"regulates"| ARRB1
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ARRB1

Outgoing (12)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ARRB1	data_in	dataset_row	0.00
autophagy	inhibits	process	0.90
MASP1	regulates	protein	0.90
Anti-Inflammatory Reactivity	modulates	process	0.90
SAMD4	regulates	gene	0.85
RAB27A	activates	protein	0.85
SAMD4	interacts_with	protein	0.80
Carcinoma	activates	disease	0.65
Hepatitis	activates	disease	0.65
Cancer	associated_with	disease	0.65
Autophagy	activates	pathway	0.60
FKBP5	associated_with	gene	0.60

Incoming (7)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ARRB1	data_in	dataset_row	0.00
IL4	regulates	entity	0.85
IL-4	regulates	entity	0.85
AUTOPHAGY	activates	gene	0.60
MIRNAS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning arrb1 in their description or question text

No additional research found