Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | C5 |
| Protein Family | Complement system |
| Function | The C5 gene encodes a component of the complement system, part of the innate immune system involved in inflammation and immune response. |
| Subcellular Localization | Plasma |
| Molecular Weight | 190 kDa |
| Pathways | Membrane Attack Complex |
| UniProt ID | P01031 |
| GeneCards | C5 |
| Human Protein Atlas | C5 |
| C5a | A potent anaphylatoxin and pro-inflammatory mediator |
| C5b | The initiating fragment for formation of the membrane attack complex (MAC) |
| Huntington's Disease | Elevated C5a levels have been observed in HD models and may contribute to disease progression. |
| Amyotrophic Lateral Sclerosis | Complement activation, including C5, is involved in the inflammatory response in ALS. |
| Age-Related Macular Degeneration | Genetic variants in the C5 gene are associated with AMD risk. |
| Associated Diseases | neurodegeneration |
| Interactions | AQP4, C3, CD19, CR1 |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["C5"]
N1["Membrane Attack Complex Stress"]
N0 -->|"mediates"| N1
N2["Membrane Attack Complex"]
N0 -->|"involved in"| N2
N0 -->|"involved in"| N1
N3["Glaucoma"]
N0 -->|"involved in"| N3
N0 -->|"upregulates"| N3
N4["CR1"]
N0 -->|"co discussed"| N4
N5["C3"]
N5 -->|"co discussed"| N0
N6["C1Q"]
N6 -->|"co discussed"| N0
N7["neurodegeneration"]
N0 -->|"implicated in"| N7
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N2 mechanism
class N3 disease
class N4 gene
class N5 gene
class N6 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Membrane Attack Complex Stress | promotes | mechanism | 0.88 |
| Membrane Attack Complex Stress | involved_in | process | 0.85 |
| Membrane Attack Complex | involved_in | mechanism | 0.85 |
| Membrane Attack Complex Stress | mediates | process | 0.85 |
| Membrane Attack Complex Formation | activates | process | 0.85 |
| Glaucoma | involved_in | disease | 0.85 |
| Glaucoma | upregulates | disease | 0.80 |
| CLU | causes | gene | 0.60 |
| CTSF | causes | gene | 0.60 |
| SMPD1 | causes | gene | 0.60 |
| CR1 | expressed_in | gene | 0.60 |
| CFB | expressed_in | gene | 0.60 |
| CFB | causes | gene | 0.60 |
| IL12 | associated_with | gene | 0.60 |
| IL18 | associated_with | gene | 0.60 |
| IL4 | associated_with | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| IL10 | associated_with | gene | 0.60 |
| CD19 | inhibits | gene | 0.60 |
| complement cascade | participates_in | pathway | 0.60 |
| CR1 | activates | gene | 0.55 |
| ubiquitin-proteasome | participates_in | pathway | 0.55 |
| DAM microglia | expressed_in | cell_type | 0.55 |
| blood-brain barrier | participates_in | pathway | 0.55 |
| CR1 | co_discussed | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.910
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.732
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.69 · 2026-04-12
closed · Rounds: 7 · Score: 0.91 · 2026-04-10
closed · Rounds: 4 · Score: 0.89 · 2026-04-06