gene

NR1D1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR1D1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

123Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for NR1D1 — Nuclear Receptor Subfamily 1 Group D Member 1

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🧬 Gene Info

Gene Symbol	NR1D1
Full Name	Nuclear Receptor Subfamily 1 Group D Member 1 (REV-ERBα)
Chromosome	17q11.2.
Protein Type	Receptor
Function	NR1D1 (REV-ERBα) is a nuclear receptor and transcriptional repressor that is a key component of the circadian clock.
Primary Expression	most tissues with circadian oscillation
Pathways	Circadian Rhythm, Oxidative Stress
UniProt ID	[Q9UH73](https://www.uniprot.org/uniprot/Q9UH73)
Ensembl ID	ENSG00000156395
GeneCards	NR1D1
Human Protein Atlas	NR1D1
Circadian disruption	AD patients commonly exhibit circadian rhythm disturbances
Amyloid metabolism	REV-ERB regulates genes involved in amyloid precursor protein (APP) processing
Neuroinflammation	NR1D1 modulates inflammatory responses in the brain
Evidence	Circadian clock genes show altered expression in PD substantia nigra[@musiek2020]
Associated Diseases	Aging, Als, autism spectrum disorder, Inflammation, Migraine
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, CD68, CLOCK, CXCL1, IL4
KG Connections	123 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NR1D1 — Nuclear Receptor Subfamily 1 Group D Member 1 (REV-ERBα)

gene · 616 words

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Pathway Diagram

graph TD
    NR1D1["NR1D1"]
    inflammatory_responses["inflammatory responses"]
    NR1D1 -->|"regulates"| inflammatory_responses
    ROS_production["ROS production"]
    NR1D1 -->|"inhibits"| ROS_production
    Atherosclerosis{"Atherosclerosis"}
    NR1D1 -->|"inhibits"| Atherosclerosis
    Inflammation{"Inflammation"}
    NR1D1 -->|"inhibits"| Inflammation
    Als{"Als"}
    NR1D1 -->|"inhibits"| Als
    Cardiac{"Cardiac"}
    NR1D1 -->|"regulates"| Cardiac
    Ms{"Ms"}
    NR1D1 -->|"inhibits"| Ms
    NR1D1 -->|"associated with"| Als
    Aging{"Aging"}
    NR1D1 -->|"associated with"| Aging
    NR1D1 -->|"associated with"| Ms
    NR1D1 -->|"associated with"| Inflammation
    Migraine{"Migraine"}
    NR1D1 -->|"associated with"| Migraine
    SOD1_downregulation["SOD1 downregulation"]
    SOD1_downregulation -->|"activates"| NR1D1
    LC3B["LC3B"]
    LC3B -->|"expressed in"| NR1D1
    PER["PER"]
    PER -->|"expressed in"| NR1D1
    FASN["FASN"]
    FASN -->|"expressed in"| NR1D1
    NFKBIA["NFKBIA"]
    NFKBIA -->|"expressed in"| NR1D1
    PGC1A["PGC1A"]
    PGC1A -->|"expressed in"| NR1D1
    PER2["PER2"]
    PER2 -->|"activates"| NR1D1
    LPL["LPL"]
    LPL -->|"expressed in"| NR1D1
    CLOCK["CLOCK"]
    CLOCK -->|"activates"| NR1D1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"expressed in"| NR1D1
    SIRT1["SIRT1"]
    SIRT1 -->|"expressed in"| NR1D1
    PPARG["PPARG"]
    PPARG -->|"expressed in"| NR1D1
    style NR1D1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (70)

Target	Relation	Type	Str
inflammatory responses	regulates	phenotype	0.80
ROS production	inhibits	phenotype	0.80
microglial_activation	inhibits	phenotype	0.70
NFKB1	represses	gene	0.70
ALS	expressed_in	disease	0.65
Migraine	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Als	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
Sleep Disorder	expressed_in	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cardiac	regulates	disease	0.65
Ms	inhibits	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Autophagy	associated_with	pathway	0.60
Circadian Rhythm	associated_with	pathway	0.60
SCD1	inhibits	gene	0.60
Autophagy	expressed_in	pathway	0.60
Cholesterol	expressed_in	pathway	0.60
Rb	expressed_in	protein	0.60
PER1	regulates	gene	0.60
ALS	associated_with	disease	0.60
AND	expressed_in	gene	0.60
Circadian Rhythm	regulates	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
MTNR1A	expressed_in	gene	0.60
PER1	expressed_in	gene	0.60
REV	regulates	gene	0.60
RNA	regulates	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
FXN	associated_with	gene	0.60
EPHA5	associated_with	gene	0.60
EP300	associated_with	gene	0.60
NLGN2	associated_with	gene	0.60
CDK4	associated_with	gene	0.60
CHD4	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
TGFB3	associated_with	gene	0.60
MICROGLIA	activates	gene	0.60

Incoming (53)

Source	Relation	Type	Str
SOD1 downregulation	activates	gene	0.70
INFLAMMATION	inhibits	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
CLOCK	associated_with	gene	0.60
PER2	expressed_in	gene	0.60
PER3	expressed_in	gene	0.60
SOD1 DOWNREGULATION	inhibits	gene	0.60
PER1	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
CD68	activates	gene	0.60
TNF	activates	gene	0.60
ARNT	regulates	gene	0.60
ARNTL	regulates	gene	0.60
BMAL1	regulates	gene	0.60
LC3B	expressed_in	gene	0.60
PER	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
CXCL1	inhibits	gene	0.60
EGR1	regulates	gene	0.60
SOD1	inhibits	gene	0.60
TNF	inhibits	gene	0.60
KCNK5	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
TP53	associated_with	gene	0.60
REST	activates	gene	0.60
AGING	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
IL-6	activates	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	regulates	gene	0.60
FASN	expressed_in	gene	0.60
NFKBIA	expressed_in	gene	0.60
PGC1A	expressed_in	gene	0.60
PER2	activates	gene	0.60
LPL	expressed_in	gene	0.60
CLOCK	activates	gene	0.60
SIRT1	expressed_in	gene	0.60
PPARG	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
NPAS2	expressed_in	gene	0.60
MTNR1A	expressed_in	gene	0.60
MTNR1B	associated_with	gene	0.60
ARNTL	expressed_in	gene	0.60
MTNR1B	expressed_in	gene	0.60
ARNTL	co_expressed_with	gene	0.50
BMAL1	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can circadian interventions reverse microglial priming independent of sleep disr

chronobiology | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can circadian interventions reverse microglial priming independent of sleep disr

closed · Rounds: 4 · Score: 0.95 · 2026-04-10