concept

FGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

510Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FGF
Key Genes/Proteins	Actin, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, Amyloid
Related Diseases	Aging, ALS, Alzheimer
Related Pathways	Angiogenesis, Apoptosis, apoptosis pathway

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FGF["FGF"]
    style FGF fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    FGF -->|"regulates"| MTOR([MTOR])
    FGF -->|"regulates"| MYELINATION["MYELINATION"]
    FGF -->|"expressed in"| Cancer["Cancer"]
    FGF -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    FGF -->|"regulates"| Alzheimer["Alzheimer"]
    FGF -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    FGF -->|"regulates"| Inflammation["Inflammation"]
    DNA([DNA]) -->|"activates"| FGF
    FGF1([FGF1]) -->|"interacts"| FGF
    ERK1_2([ERK1/2]) -->|"activates"| FGF
    NEURODEGENERATION([NEURODEGENERATION]) -->|"regulates"| FGF
    EXERCISE([EXERCISE]) -->|"regulates"| FGF
    NEUROINFLAMMATION([NEUROINFLAMMATION]) -->|"regulates"| FGF
    MITOCHONDRIAL_DYSFUNCTION([MITOCHONDRIAL DYSFUNCTION]) -->|"regulates"| FGF
    ASTROCYTE([ASTROCYTE]) -->|"regulates"| FGF
    ALZHEIMER([ALZHEIMER]) -->|"regulates"| FGF
    FGF2([FGF2]) -->|"interacts"| FGF

Outgoing (229)

Target	Relation	Type	Str
NEURONS	transports	cell_type	0.70
SIRT1	activates	gene	0.70
TFEB	activates	gene	0.70
ULK1	activates	gene	0.70
SQSTM1	activates	gene	0.70
SOD2	activates	gene	0.70
SOD1	activates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
astrocytes	expressed_in	cell_type	0.70
TGF-beta signaling	participates_in	pathway	0.70
Cancer	expressed_in	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
MTOR	regulates	gene	0.65
Parkinson	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	activates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Glioblastoma	associated_with	disease	0.65
Lipid Metabolism	regulates	pathway	0.60
EGFR	inhibits	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
Fibroblast	inhibits	cell_type	0.60
Als	degrades	disease	0.60
Als	biomarker_for	disease	0.60
Senescence	biomarker_for	disease	0.60
Aging	biomarker_for	disease	0.60
Fibrosis	biomarker_for	disease	0.60
NEURON	co_discussed	cell_type	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
TAU	regulates	gene	0.60
Oxidative Stress	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
Amyloid	regulates	pathway	0.60
Neuroinflammation	inhibits	disease	0.60
Als	expressed_in	disease	0.60
Cancer	regulates	disease	0.60
TP53	activates	gene	0.60
Fibroblast	activates	cell_type	0.60

Incoming (281)

Source	Relation	Type	Str
ASTROCYTE	transports	cell_type	0.70
ATG5	interacts_with	gene	0.70
ATG7	interacts_with	gene	0.70
BCL-2	regulates	gene	0.60
LGALS9	regulates	gene	0.60
EPOR	regulates	gene	0.60
STAT1	regulates	gene	0.60
ISG15	regulates	gene	0.60
P38	regulates	gene	0.60
TLR4	regulates	gene	0.60
ERK	regulates	gene	0.60
CXCL10	regulates	gene	0.60
EPO	regulates	gene	0.60
CSF2	regulates	gene	0.60
MAPK	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
CATHEPSIN-B	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IGF-1	activates	gene	0.60
AGING	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NLRP3	associated_with	gene	0.60
FGF2	associated_with	gene	0.60
IL13	associated_with	gene	0.60
ICAM1	associated_with	gene	0.60
RAS	expressed_in	gene	0.60
HIF1A	associated_with	gene	0.60
PPAR	associated_with	gene	0.60
MIRNAS	expressed_in	gene	0.60
IRS1	associated_with	gene	0.60
MRC1	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
FGFR2	inhibits	gene	0.60
TP53	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
DNA	inhibits	gene	0.60
B3GALT6	activates	gene	0.60
TSC1	inhibits	gene	0.60
MAPK	inhibits	gene	0.60
PIK3CA	inhibits	gene	0.60
TPR	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
ESR1	associated_with	gene	0.60
PBRM1	associated_with	gene	0.60
RB1	associated_with	gene	0.60
PCDH15	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
FGFR2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGF in their description or question text

No additional research found

FGF

Understanding Entity Pages

Wiki Pages (21)

Neural Precursor Development

FGF10 — Fibroblast Growth Factor 10

FGF23 — Fibroblast Growth Factor 23

FGF Signaling Pathway in Neurodegeneration

FGF7 — Fibroblast Growth Factor 7

FGF Signaling in Parkinson's Disease

FGF6 Gene

FGF8 Gene

FGF21 — Fibroblast Growth Factor 21

FGF16 Gene

FGF13-MTCH2 Neuroprotection in Parkinson's Disease

FGF4 — Fibroblast Growth Factor 4

FGF-2 Protein (bFGF)

AD FGF/FGFR Signaling Companies

FGF17 Protein

FGFR3 - Fibroblast Growth Factor Receptor 3

PD FGF/FGFR Signaling Companies

FGF13 — Fibroblast Growth Factor 13

Fibroblast Growth Factor 21 (FGF21)

FGF14 — Fibroblast Growth Factor 14

FGF19 — Fibroblast Growth Factor 19