concept

CIRCADIAN RHYTHM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CIRCADIAN RHYTHM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1214Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

6Experiments

0Debates

Summary

CIRCADIAN RHYTHM is a concept in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with ALS, Aging, Als. Connected to 376 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CIRCADIAN RHYTHM
Key Genes/Proteins	ACHE, AGING, AHR, AKT, ALZHEIMER, ALZHEIMER DISEASE
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt

Pathway Diagram

graph TD
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    CIRCADIAN_RHYTHM -->|"regulates"| lipid_metabolism["lipid metabolism"]
    CIRCADIAN_RHYTHM -->|"inhibits"| Ischemia["Ischemia"]
    CIRCADIAN_RHYTHM -->|"inhibits"| Aging["Aging"]
    CIRCADIAN_RHYTHM -->|"regulates"| Ms["Ms"]
    CIRCADIAN_RHYTHM -->|"regulates"| Depression["Depression"]
    CIRCADIAN_RHYTHM -->|"regulates"| Cancer["Cancer"]
    CIRCADIAN_RHYTHM -->|"regulates"| Tumor["Tumor"]
    BMAL1["BMAL1"] -->|"regulates"| CIRCADIAN_RHYTHM
    BANG["BANG"] -->|"regulates"| CIRCADIAN_RHYTHM
    CLOCK["CLOCK"] -->|"regulates"| CIRCADIAN_RHYTHM
    CRY["CRY"] -->|"regulates"| CIRCADIAN_RHYTHM

Outgoing (436)

Target	Relation	Type	Str
Circadian Rhythm	regulates	pathway	1.00
Gastrointestinal Function	regulates	process	0.95
Immune Cell Function	regulates	process	0.95
Gastrointestinal Disease	regulates	disease	0.95
IMMUNE CELLS	regulates	entity	0.92
Gut Health	modulates	phenotype	0.90
Intestinal Barrier Function	regulates	process	0.90
Gut Health	regulates	phenotype	0.90
Microbiome Composition	modulates	process	0.90
Gastrointestinal Immune Function	regulates	process	0.90
Intestinal Microbiota	modulates	pathway	0.90
DIGESTION	regulates	entity	0.90
ABSORPTION	regulates	entity	0.90
Mood Disorders	regulates	disease	0.90
Gastrointestinal Motility	modulates	process	0.90
Immune Function	regulates	process	0.90
Intestinal Motility	regulates	process	0.90
Gut Microbiome	regulates	process	0.90
Digestion	regulates	process	0.90
Nutrient Absorption	regulates	process	0.90
Tumor Development	involved_in	disease	0.90
Myocardial Injury	associated_with	phenotype	0.90
Cancer	involved_in	disease	0.90
Brain Lipid Metabolism	regulates	process	0.90
Immune Response	regulates	process	0.90
Absorption	regulates	process	0.90
INTESTINAL BARRIER FUNCTION	regulates	entity	0.90
IMMUNE FUNCTION	regulates	entity	0.90
Digestion	associated_with	process	0.90
Intestinal Homeostasis	regulates	process	0.85
Gut Health	contributes_to	phenotype	0.85
myocardial infarction	associated_with	disease	0.80
daytime napping	regulates	phenotype	0.80
Tumor Microenvironment	regulates	process	0.80
Chronic Gastrointestinal Disease	associated_with	disease	0.80
Circadian Rhythm	associated_with	pathway	0.80
Inflammatory Gastrointestinal Conditions	associated_with	disease	0.78
Inflammation	activates	disease	0.75
Cancer	associated_with	disease	0.75
chemotherapy efficacy	modulates	phenotype	0.75
Metabolic Pathways	regulates	pathway	0.75
Aging	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
Autophagy	regulates	pathway	0.70
Huntington's disease	associated_with	disease	0.70
INSULIN RESISTANCE	activates	gene	0.70
Alzheimer's disease	associated_with	disease	0.70
Parkinson's disease	associated_with	disease	0.70
lipid metabolism	regulates	pathway	0.70
Oxidative Stress	regulates	pathway	0.70

Incoming (778)

Source	Relation	Type	Str
CIRCADIAN RHYTHM	regulates	gene	1.00
HYPOTHALAMUS	regulates	entity	0.95
OBSTRUCTIVE SLEEP APNEA SYNDROME	associated_with	entity	0.95
CRY	drives	gene	0.95
Suprachiasmatic Nucleus	regulates	cell_type	0.95
PER	drives	gene	0.95
Alzheimer's Disease	associated_with	disease	0.95
Parkinson's Disease	associated_with	disease	0.95
CLOCK	drives	gene	0.95
BMAL1	drives	gene	0.95
ASTROCYTES	regulates	cell_type	0.95
Huntington's Disease	associated_with	disease	0.95
suprachiasmatic nucleus	associated_with	brain_region	0.93
BMAL1	associated_with	gene	0.90
INTERMITTENT HYPOXIA	associated_with	entity	0.90
SLEEP	modulates	entity	0.90
EATING TIMES	modulates	entity	0.90
LIGHT	modulates	entity	0.90
MELATONIN	biomarker_for	entity	0.90
SLEEP FRAGMENTATION	associated_with	entity	0.90
BMAL1	associated_with	protein	0.90
Hypothalamus	mediates	cell_type	0.90
Intermittent Hypoxia	associated_with	mechanism	0.90
Hypothalamus	regulates	cell_type	0.90
HIF2A	regulates	protein	0.90
Light Exposure	modulates	phenotype	0.85
Environmental Cycles	modulates	phenotype	0.85
Sleep	modulates	phenotype	0.85
Social Jet Lag	inhibits	phenotype	0.85
Shift Work	inhibits	phenotype	0.85
Light	modulates	compound	0.85
SIRT1	regulates	protein	0.85
Eating Time	associated_with	phenotype	0.85
Microbiome	associated_with	structure	0.82
CRY	participates_in	gene	0.80
PER	participates_in	gene	0.80
Mistimed Eating	associated_with	phenotype	0.80
Night-Time Light Exposure	inhibits	phenotype	0.80
Shift Work	associated_with	phenotype	0.80
PER2PROTEIN	participates_in	protein	0.80
BMAL1	participates_in	gene	0.80
CLOCK	associated_with	gene	0.80
PER	involved_in	gene	0.80
CLOCK	part_of	gene	0.80
PER2	expressed_in	gene	0.80
GENES	regulates	gene	0.80
CLOCK	regulates	gene	0.80
CIRCADIAN RHYTHM	associated_with	gene	0.80
CLOCK	regulates	gene	0.80
Als	associated_with	disease	0.80

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circadian Rhythm Entrainment of Reactive Astrocytes	0.722	neurodegeneration	Astrocyte reactivity subtypes in neurode
Circadian Rhythm Amplification to Restore Network Oscillatio	0.360	connectomics	Human connectome alterations in Alzheime

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (6)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Circadian gene expression effects of SD vs ketamine	exploratory	depression	0.950	0.00	C57BL/6J mice	proposed	N/A
CLOCK/BMAL1 regulation of ICC autophagy in GERD model	exploratory	gastroesophageal reflux diseas	0.900	0.00	primary esophageal interstitia	proposed	N/A
Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Brainstem Circuit Modulation for PSP	clinical	ALS	0.400	0.50	human	proposed	$5,460,000
Non-Dopaminergic Neurotransmitter Degeneration in PD - Experiment Desi	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. [PMID:40269168]	Ruan W, Li T, Bang IH, Lee J, Deng W, Ma	Nature	2025	1
Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: The link with th [PMID:39864923]	Fernandes M, Liguori C	Handb Clin Neurol	2025	1
Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases. [PMID:39728504]	Hussain Y, Dar MI, Pan X	Metabolites	2024	1
Circadian rhythm regulates the function of immune cells and participates in the [PMID:38678017]	Zeng Y, Guo Z, Wu M, Chen F, Chen L	Cell Death Discov	2024	1
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases. [PMID:32705594]	Pan X, Mota S, Zhang B	Adv Exp Med Biol	2020	1
BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/ [PMID:41909150]	Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wa	Biochemistry and biophysics re	2026	0
Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646]	Lin L, Liang X, Xu Z, Li Y, Guo Z et al.	Biomaterials	2026	0
The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525]	Sica V, Sato T, Tsialtas I, Hernandez S,	J Biol Rhythms	2026	0
Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008]	Tsameret S, Froy O, Matz Y, Landau Z, Tw	Diabetologia	2026	0
Bmal1 Regulates Vascular Calcification via Noncanonical Circadian Pathway-Brief [PMID:41608773]	He M, Sun Y, Tang C, Huang F, Zhu Z et a	Arterioscler Thromb Vasc Biol	2026	0
Liver-specific knockout of CD73 exacerbated alcohol-associated steatohepatitis b [PMID:41833677]	Wu X, Zhang Q, Wang QQ, Liu ZN, Ni YY et	Int J Biol Macromol	2026	0
Circadian disruption and its clinical implications in Parkinson's disease: A Nar [PMID:41905255]	Kataoka H, Saeki K, Sugie K, Obayashi K	Sleep medicine	2026	0
The neuroprotective role of eugenol against glyphosate-induced toxicity in rats: [PMID:41922126]	Bolat İ, Alat Ö, Orhan B, Dereli E, Teki	Tissue & cell	2026	0
Circadian abnormalities, molecular clock gene and chronobiological treatment for [PMID:41913359]	Chakraborty S, Srivastava V	Chronobiology international	2026	0
The rhythm of decline: Circadian disruption in neurodegeneration. [PMID:41066745]	Singh J, Kumar D, Kaur J, Singh A	Journal of food and drug analy	2025	0
Core Circadian Protein BMAL1: Implication for Nervous System Functioning and Its [PMID:41440117]	Smirnova KV, Smirnova LP, Amstislavskaya	Brain sciences	2025	0
Pharmacological targeting of BMAL1 modulates circadian and immune pathways. [PMID:40133642]	Pu H, Bailey LC, Bauer LG, Voronkov M, B	Nature chemical biology	2025	0
Circadian Rhythm Dysfunction in Neurodegenerative Diseases: A Bidirectional Pers [PMID:41287625]	Namgyal D, Lim CS	Nature and science of sleep	2025	0
Disrupted circadian control promotes oncogenesis in breast cancer. [PMID:41908013]	Fatima Y, Kashif M, Jain PA	Bioinformation	2025	0
Disruption of the circadian clock component BMAL1 elicits an endocrine adaption [PMID:35238641]	Jouffe C, Weger BD, Martin E, Atger F, W	Proceedings of the National Ac	2022	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CIRCADIAN RHYTHM in their description or question text

No additional research found