gene

REST

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

336Connections

30Hypotheses

4Analyses

50Outgoing

50Incoming

2Experiments

4Debates

Summary

REST is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with ALS, Aging, Als. Connected to 157 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	REST
Full Name	RE1-Silencing Transcription Factor
Chromosome	4q12
Protein Type	Transcription Factor
Function	REST (also known as NRSF) is a zinc-finger transcription factor that represses neuronal gene expression in non-neuronal cells and regulates synaptic plasticity in neurons.
Pathways	Autophagy, Circadian Rhythm, Epigenetic, Immune Response, Lipid Metabolism
UniProt ID	Q9Y2W1
NCBI Gene ID	5978
Ensembl ID	ENSG00000100647
OMIM	600571
GeneCards	REST
Human Protein Atlas	REST
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Ataxia, Atherosclerosis
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND, APOER2, APOPTOSIS
SciDEX Hypotheses	REST Complex Dysregulation as Master Epigenetic Sw REST-like neuronal silencing programs suppress MAP
KG Connections	336 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: REST — AlphaFold Q9Y2W1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

REST Gene

gene · 720 words

→

SS18L1 (CREST) (SS18L1)

gene · 826 words

→

Pathway Diagram

graph TD
    REST["REST"] -->|"protects against"| Dementia["Dementia"]
    REST["REST"] -->|"regulates"| OGDHL["OGDHL"]
    REST["REST"] -.->|"inhibits"| Alzheimer["Alzheimer"]
    REST["REST"] -.->|"inhibits"| Ms["Ms"]
    REST["REST"] -.->|"inhibits"| Als["Als"]
    REST["REST"] -.->|"inhibits"| Aging["Aging"]
    CD2AP["CD2AP"] -->|"activates"| REST["REST"]
    NRF2["NRF2"] -->|"activates"| REST["REST"]
    CLOCK["CLOCK"] -->|"regulates"| REST["REST"]
    GENES["GENES"] -->|"regulates"| REST["REST"]
    style REST fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (238)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.85
Als	associated_with	disease	0.75
Aging	associated_with	disease	0.75
SYP	co_expressed_with	protein	0.75
Alzheimer	associated_with	disease	0.75
Tumor	inhibits	disease	0.75
Als	inhibits	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	regulates	disease	0.75
PARKINSON	associated_with	gene	0.70
PARKINSON'S DISEASE	associated_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
Neuroinflammation	expressed_in	disease	0.65
Parkinson	causes	disease	0.65
Inflammation	expressed_in	disease	0.65
neurons	expressed_in	cell_type	0.65
Obesity	regulates	disease	0.65
Cancer	activates	disease	0.65
Lung Cancer	activates	disease	0.65
ALS	inhibits	disease	0.65
Aging	expressed_in	disease	0.65
Als	protects_against	disease	0.65
Als	treats	disease	0.65
Depression	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Ataxia	associated_with	disease	0.65
Dystonia	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Autoimmune	activates	disease	0.65
ALS	activates	disease	0.65
Als	expressed_in	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Aging	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Infection	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	associated_with	disease	0.65
Dementia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	activates	disease	0.65
Chronic Kidney Disease	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Inflammation	biomarker_for	disease	0.65

Incoming (98)

Source	Relation	Type	Str
PARKINSON'S DISEASE	associated_with	gene	0.70
PARKINSON	associated_with	gene	0.70
GENES	regulates	gene	0.70
ALZHEIMER'S DISEASE	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
GENES	treats	gene	0.60
ALS	biomarker_for	gene	0.60
ALS	expressed_in	gene	0.60
ALS	protects_against	gene	0.60
EGFR	associated_with	gene	0.60
PTEN	inhibits	gene	0.60
TP53	inhibits	gene	0.60
CLOCK	associated_with	gene	0.60
MTDNA	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
NEURON	activates	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PER	associated_with	gene	0.60
CANCER	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
MTOR	activates	gene	0.60
AND	activates	gene	0.60
RNA	activates	gene	0.60
EXERCISE	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
NRSF	activates	gene	0.60
CD2AP	activates	gene	0.60
EEF2	inhibits	gene	0.60
EGFR	activates	gene	0.60
CD2AP	regulates	entity	0.60
CIRCADIAN RHYTHM	expressed_in	gene	0.60
APOER2	activates	gene	0.60
AND	inhibits	gene	0.60
APOER2	protects_against	gene	0.60
CD2AP	inhibits	entity	0.60
GRIA1	regulates	gene	0.60
BDNF	inhibits	gene	0.60
PSD95	inhibits	gene	0.60
HDAC4	regulates	gene	0.60
SYN1	regulates	gene	0.60
GRM3	regulates	gene	0.60
NRF2	protects_against	gene	0.60
PARKINSON'S DISEASE	causes	gene	0.60
PARKINSON	causes	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound with 40Hz gamma	1.000	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.948	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore	0.944	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.927	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.922	Alzheimer's disease	Circuit-level neural dynamics in neurode

Chromatin Remodeling-Mediated Nutrient Sensing Restoration	0.914	neurodegeneration	Epigenetic reprogramming in aging neuron
Closed-loop transcranial focused ultrasound to restore hippo	0.912	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.900	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II SST interneurons to block t	0.896	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optimized Temporal Window for Metabolic Boosting Therapy Det	0.879	neurodegeneration	How do different microglial subtypes (DA
Optogenetic restoration of hippocampal gamma oscillations vi	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.858	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gamma entrainment therapy to restore hippocampal-cortical sy	0.851	Alzheimer's disease	Circuit-level neural dynamics in neurode
APOE-Dependent Autophagy Restoration	0.850	neurodegeneration	Mechanistic role of APOE in neurodegener
p38α Inhibitor and PRMT1 Activator Combination to Restore Ph	0.848	neurodegeneration	What is the therapeutic window between i
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.846	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.845	Alzheimer's disease	Circuit-level neural dynamics in neurode
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	View
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.831	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy	0.812	neurodegeneration	View
Targeting the Mechanistic Link Between AQP4 Dysfunction and	0.803	neurodegeneration	View
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	Alzheimer's disease	Circuit-level neural dynamics in neurode
NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A	0.790	neurodegeneration	epigenetic reprogramming aging neurons
Closed-loop transcranial alternating current stimulation to	0.785	Alzheimer's disease	Circuit-level neural dynamics in neurode
Prefrontal sensory gating circuit restoration via PV interne	0.775	Alzheimer's disease	Circuit-level neural dynamics in neurode
Alpha-gamma cross-frequency coupling enhancement to restore	0.775	Alzheimer's disease	Circuit-level neural dynamics in neurode
Chromatin Accessibility Restoration via BRD4 Modulation	0.768	neurodegeneration	Epigenetic reprogramming in aging neuron

Mentioning Analyses (4)

Scientific analyses that reference this entity

Comparative epigenetic signatures: DNA methylation age acceleration and histone

neurodegeneration | 2026-04-18 | 7 hypotheses Top: 0.620

Comparative epigenetic signatures across AD, PD, and ALS

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.550

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Investigate shared DNA methylation age acceleration and histone modification pat

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

What are the shared DNA methylation age acceleration and histone modification pa

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Astrocyte reactivity subtypes in neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning REST in their description or question text

Chromatin Remodeling-Mediated Nutrient Sensing Restoration

Score: 0.914 · neurodegeneration · 2026-04-12

## Mechanistic Overview Chromatin Remodeling-Mediated Nutrient Sensing Restoration starts from the claim that modulating

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.912 · Alzheimer's disease · 2026-04-12

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via cholec

Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

Score: 0.900 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma gating and bloc

Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and r

Score: 0.896 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant

Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of M

Score: 0.879 · neurodegeneration · 2026-04-16

## Mechanistic Overview Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of Microglial State

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Score: 0.863 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Optogenetic restoration of hippocampal gamma oscillations via selective PV interneuron activatio

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

Score: 0.863 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling a

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.858 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct

Gamma entrainment therapy to restore hippocampal-cortical synchrony

Score: 0.851 · Alzheimer's disease · 2026-04-02

## Mechanistic Overview Gamma entrainment therapy to restore hippocampal-cortical synchrony starts from the claim that m

APOE-Dependent Autophagy Restoration

Score: 0.850 · neurodegeneration · 2026-04-02

## Mechanistic Overview APOE-Dependent Autophagy Restoration starts from the claim that modulating MTOR within the disea

p38α Inhibitor and PRMT1 Activator Combination to Restore Physiological TDP-43 P

Score: 0.848 · neurodegeneration · 2026-04-13

## Mechanistic Overview p38α Inhibitor and PRMT1 Activator Combination to Restore Physiological TDP-43 Phosphorylation-M

Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening

Score: 0.846 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening to restore hippo

Optogenetic restoration of hippocampal gamma oscillations via selective SST inte

Score: 0.845 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Optogenetic restoration of hippocampal gamma oscillations via selective SST interneuron activati

Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Pre

Score: 0.838 · neurodegeneration · 2026-04-17

## Mechanistic Overview Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents the Self-A

Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth

Score: 0.831 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and bl