protein

CD68

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD68: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

691Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CD68 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, expressed in. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 214 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CD68
Full Name	Cluster of Differentiation 68
Aliases	Macrosialin
Chromosome	17p13.1
Function	CD68 is a member of the lysosomal-associated membrane protein (LAMP) family:
Primary Expression	monocytes and macrophages
Amino Acids	22 aa
Pathways	Glial Phagocytosis
NCBI Gene ID	968
Ensembl ID	ENSG00000129226
OMIM	609453
GeneCards	CD68
Human Protein Atlas	CD68
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, cancer
Interactions	ABCA1, ACSL4, Actin, AGING, AIF1, AKT
KG Connections	691 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CD68 Gene

gene · 576 words

→

CD68 Protein (Macrosialin)

protein · 675 words

→

Pathway Diagram

graph TD
    CD68["CD68"]
    CD68 -.biomarker for.-> Cancer["Cancer"]
    CD68 -.biomarker for.-> Als["Als"]
    CD68 -.biomarker for.-> Inflammation["Inflammation"]
    CD68 -.biomarker for.-> Aging["Aging"]
    CD68 -.biomarker for.-> Ms["Ms"]
    CD68 -->|"expressed in"| Tumor["Tumor"]
    CD68 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    MMP9["MMP9"] -.biomarker for.-> CD68
    S100A8["S100A8"] -->|"expressed in"| CD68
    CD47["CD47"] -->|"inhibits"| CD68
    GFAP["GFAP"] -->|"expressed in"| CD68
    TNF["TNF"] -->|"inhibits"| CD68
    TLR4["TLR4"] -->|"inhibits"| CD68
    CASP3["CASP3"] -->|"expressed in"| CD68
    ANXA1["ANXA1"] -->|"expressed in"| CD68
    CGAS["CGAS"] -->|"activates"| CD68

Outgoing (424)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
macrophage activation	biomarker_for	process	0.85
Glial Phagocytosis	involved_in	process	0.80
macrophages	expressed_in	cell_type	0.80
IL-10	activates	gene	0.75
Als	activates	disease	0.75
Inflammation	activates	disease	0.75
Sarcopenia	biomarker_for	disease	0.75
oxidative stress response	participates_in	pathway	0.70
Nf-Κb	inhibits	pathway	0.70
MTOR	activates	gene	0.70
Mtor	activates	pathway	0.70
Ferroptosis	activates	pathway	0.70
Apoptosis	inhibits	pathway	0.70
Obesity	activates	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Cardiovascular	contributes_to	disease	0.65
Atherosclerosis	contributes_to	disease	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
Fibrosis	inhibits	disease	0.65
Atherosclerosis	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Ovarian Cancer	activates	disease	0.65
Osteoarthritis	activates	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Als	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Depression	activates	disease	0.65
Stroke	activates	disease	0.65
ALS	associated_with	disease	0.65
DAM microglia	expressed_in	cell_type	0.65
MACROPHAGES	interacts_with	cell_type	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
GFAP	activates	gene	0.65
Cancer	expressed_in	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	activates	disease	0.65
Rheumatoid Arthritis	activates	disease	0.65
Lupus	activates	disease	0.65
Osteoarthritis	associated_with	disease	0.65

Incoming (267)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
MICROGLIA	associated_with	cell_type	0.72
NF-ΚB	inhibits	gene	0.70
ROS	inhibits	gene	0.70
BAX	inhibits	gene	0.70
NRF2	inhibits	gene	0.70
ALZHEIMER'S DISEASE	associated_with	disease	0.66
IL-6	associated_with	gene	0.66
MICROGLIA	activates	gene	0.66
TNF	associated_with	gene	0.66
MICROGLIAL ACTIVATION	inhibits	phenotype	0.65
RNA	contributes_to	gene	0.60
MICROGLIA	regulates	gene	0.60
IL-6	inhibits	gene	0.60
CIRCADIAN RHYTHM	activates	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
ALDH1L1	biomarker_for	gene	0.60
CD8	associated_with	gene	0.60
CD4	associated_with	gene	0.60
TAU	associated_with	gene	0.60
IBA1	biomarker_for	gene	0.60
STROKE	activates	gene	0.60
GENES	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
RAGE	inhibits	gene	0.60
TGM2	associated_with	gene	0.60
ITGAM	biomarker_for	gene	0.60
C1QC	biomarker_for	gene	0.60
C1QA	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
BECLIN1	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
TFEB	activates	gene	0.60
P62	activates	gene	0.60
WIPI2	expressed_in	gene	0.60
TNF-Α	activates	gene	0.60
LAMP1	activates	gene	0.60
NF-ΚB	activates	gene	0.60
AGING	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
CANCER	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
ENDOSOME	expressed_in	gene	0.60
ANXIETY	regulates	gene	0.60
AGING	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
PARKINSON	activates	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
PROINFLAMMATORY CYTOKINES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD68 in their description or question text

No additional research found