concept

CLDN4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLDN4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

0Analyses

43Outgoing

28Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CLDN4
Key Genes/Proteins	ADCYAP1R1, AHR, AND, App, ARNT, ATP1A2
Related Diseases	Als, ALS, Cancer

Pathway Diagram

graph TD
    CLDN4["CLDN4"]
    CLDN4 -->|"inhibits"| Als["Als"]
    CLDN4 -->|"regulates"| Tumor["Tumor"]
    CLDN4 -->|"inhibits"| ALS["ALS"]
    CLDN4 -.biomarker for.-> Cancer["Cancer"]
    CLDN4 -->|"inhibits"| STAT6["STAT6"]
    CLDN4 -->|"inhibits"| ARNT["ARNT"]
    CLDN4 -->|"inhibits"| NRF2["NRF2"]
    CLDN4 -->|"expressed in"| OCLN["OCLN"]
    IL4["IL4"] -->|"inhibits"| CLDN4
    IL13["IL13"] -->|"inhibits"| CLDN4
    BENVITIMOD["BENVITIMOD"] -->|"activates"| CLDN4
    CLDN1["CLDN1"] -->|"expressed in"| CLDN4
    AHR["AHR"] -->|"inhibits"| CLDN4
    OCLN -->|"expressed in"| CLDN4
    NRF2 -->|"inhibits"| CLDN4
    ARNT -->|"inhibits"| CLDN4

Outgoing (43)

Target	Relation	Type	Str
Glioblastoma	promotes	disease	0.90
cell migration	promotes	process	0.85
Glioblastoma Multiforme	promotes	disease	0.85
tumor cell proliferation	promotes	process	0.80
Cancer	biomarker_for	disease	0.65
ALS	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Als	inhibits	disease	0.65
CANCER	biomarker_for	gene	0.60
SCN4B	associated_with	gene	0.60
Cytokine	inhibits	protein	0.60
Il-1	expressed_in	protein	0.60
Rb	activates	protein	0.60
App	biomarker_for	protein	0.60
OCLN	regulates	gene	0.60
OCLN	inhibits	gene	0.60
OCLN	activates	gene	0.60
NTRK2	interacts_with	gene	0.60
SCN4B	interacts_with	gene	0.60
SLC17A7	interacts_with	gene	0.60
GBM	activates	gene	0.60
glioblastoma	activates	disease	0.60
STAT6	inhibits	gene	0.60
ARNT	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
OCLN	expressed_in	gene	0.60
CANCER	associated_with	gene	0.60
CDH1	regulates	gene	0.60
ERBB3	associated_with	gene	0.60
CYTOKINES	inhibits	gene	0.60
JAK	inhibits	gene	0.60
CLDN1	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
IL-13	expressed_in	gene	0.60
IL-4	expressed_in	gene	0.60
ATP1A2	associated_with	gene	0.60
SLC17A7	associated_with	gene	0.60
AND	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
NTRK2	associated_with	gene	0.60
ROS	inhibits	gene	0.60
T Cell	expressed_in	cell_type	0.55

Incoming (28)

Source	Relation	Type	Str
BENVITIMOD	upregulates	compound	0.80
BENVITIMOD	activates	drug	0.72
IL4	inhibits	protein	0.72
IL13	inhibits	protein	0.72
ADCYAP1R1	interacts_with	gene	0.60
CLDN3	activates	gene	0.60
CLDN1	expressed_in	gene	0.60
AHR	inhibits	gene	0.60
OCLN	expressed_in	gene	0.60
NRF2	inhibits	gene	0.60
ARNT	inhibits	gene	0.60
TGFB1	associated_with	gene	0.60
TGFBR2	associated_with	gene	0.60
STAT6	inhibits	gene	0.60
GATA3	regulates	gene	0.60
CYTOKINES	inhibits	gene	0.60
GENES	associated_with	gene	0.60
IL-4	expressed_in	gene	0.60
SCN4B	associated_with	gene	0.60
SLC17A7	associated_with	gene	0.60
NTRK2	associated_with	gene	0.60
IL-13	expressed_in	gene	0.60
ROS	inhibits	gene	0.60
ATP1A2	associated_with	gene	0.60
CLDN1	regulates	gene	0.60
CLDN1	inhibits	gene	0.60
ATP1A2	interacts_with	gene	0.60
JAK	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLDN4 in their description or question text

No additional research found