gene 801 words KG: IL4
Contents

IL4 Gene

🧬 Gene Info
Gene SymbolIL4
Full NameInterleukin 4
Chromosome5q31.3
FunctionThe IL4 gene encodes a protein involved in cellular signaling that is critical for development, tissue homeostasis, and immune regulation.
Primary Expressionvarious brain regions including cortex, hippocampus, and basal ganglia
Molecular Weight15 kDa
Amino Acids129 aa
PathwaysAutophagy
UniProt ID[P05112](https://www.uniprot.org/uniprot/P05112)
Ensembl IDENSG00000100994
GeneCardsIL4
Human Protein AtlasIL4
Associated DiseasesIschemia
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AND, , BMAL1, CCL2
KG Connections205 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (17)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (15)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: therapeutic_target
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
ARRB1 — Arrestin Beta 1
gene · KG edge: regulates
ARRB2 — Arrestin Beta 2
gene · KG edge: regulates

Knowledge Graph (12 edges)

IL4 inhibits CLDN1
IL4 inhibits OCLN
IL9 activates IL4
VEGFA biomarker_for IL4
IL4 activates FGF2
IL4 biomarker_for GFAP
IL4 biomarker_for NPTX1
IL4 biomarker_for CHIT1
IL4 biomarker_for MDH1
IL4 biomarker_for PDGFRB

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